Iron deficiency and protection of blood donors

Souza, Cármino Antonio De

doi:10.1590/s1516-31802001000400002

Cited by 2 publications

(3 citation statements)

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“…The fact that the non-anemic individuals in this study presented ferritin levels higher than anemic candidates, although expected, reinforces the importance of this test in the propedeutics of anemic donors. In addition, identifying non-anemic donors with low levels of ferritin (10.6%) should be the reason for prompt intervention to prevent anemia; this supports the position of some authors who suggest that ferritin should be measured in the screening of donors ( 19 - 23 ) , particularly those who donated more than five times ( 5 , 19 ) as well as iron supplementation for iron deficiency ( 24 , 25 ) .…”

Section: Discussionsupporting

confidence: 52%

Etiology of anemia of blood donor candidates deferred by hematologic screening

Silva¹,

Souza²,

Carlos³

et al. 2012

Revista Brasileira De Hematologia E Hemoterapia

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Objective: Iron deficiency is the most common cause of anemia and one of the main factors in the clinical deferral of blood donors. This fact prompted the current study that aimed to determine the prevalence and etiology of anemia in blood donor candidates and to evaluate the hematological screening technique used for the exclusion of these donors. Methods: This was a prospective study that compared two groups (Anemic and Non-anemic). Initially screening for anemia was performed by manually measuring hemoglobin (Bioclin® Kit); the results were subsequently compared with an automated screening method (Coulter T-890). The etiology was investigated by hemoglobin electrophoresis in alkaline and acid pH, Hb A2 dosage and measurement of the ferritin concentration by immunoagglutination. Differences and associations of interest were analyzed using the Yates and McNemar's Chi-square tests and the Fisher, Mann-Whitney, Wilcoxon and Kruskal-Wallis tests. Results: The deferral rate due to anemia was 4.2%; iron deficiency was identified in 37.5% and beta thalassemia in 9.3% of the excluded candidates. There was a significant discrepancy between the two techniques used to measure hemoglobin with 38.1% of initially deferred donors presenting normal hemoglobin levels by the automated method. Conclusion: The results show a high rate of blood donors being deferred for anemia and confirm that iron deficiency is the most prevalent cause. The discrepancies found by comparing screening methods suggest that hemoglobin and hematocrit levels should be confirmed before deferring a donor due to anemia; this may increase supplies in blood banks.

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Section: Discussionsupporting

confidence: 52%

Etiology of anemia of blood donor candidates deferred by hematologic screening

Silva¹,

Souza²,

Carlos³

et al. 2012

Revista Brasileira De Hematologia E Hemoterapia

View full text Add to dashboard Cite

show abstract

“…Certainly, this is one of the most aggressive pharmacological regimens of anticoagulation and antiplatelet therapy used in modern cardiology. 3 In August 2001, clopidogrel arose and it began to be prescribed commonly to prevent coronary thrombosis after interventions. 3 Clopidogrel has an antiplatelet effect for about six hours after a loading dose of 300 mg and about two hours after a dose of 600 mg orally.…”

Section: Introductionmentioning

confidence: 99%

“…3 In August 2001, clopidogrel arose and it began to be prescribed commonly to prevent coronary thrombosis after interventions. 3 Clopidogrel has an antiplatelet effect for about six hours after a loading dose of 300 mg and about two hours after a dose of 600 mg orally. This inhibition reaches a steady state between 3 and 7 days with repeated doses.…”

Section: Introductionmentioning

confidence: 99%