Diagnostic value of fecal leukocytes in chronic bowel diseases

Sevá-Pereira, A; Franco, Alberto Otoniel; Magalhães, Adriana Gomes

doi:10.1590/s1516-31801994000100006

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…Moreover, in 14 cases, Faecal Leukocyte Test (FLT) was determined, and 9 of them (64.3%) were positive, including PUCV-1, PUCV-2, and PUCV-3 (Table S1). Although the utility of FLT has been discussed due to its inability to estimate stool culture results and response to antimicrobials, not necessarily their inability to detect inflammation, which may have many causes, the association between the presence of faecal leukocytes and exudative enteropathy such as ulcerative colitis, Crohn's disease, amoebic colitis, eosinophilic colitis, and even colonic carcinoma has been previously demonstrated [35, 36].…”

Section: Discussionmentioning

confidence: 99%

Genomic Analysis of Chilean Strains ofCampylobacter jejunifrom Human Faeces

Levicán

Ramos-Tapia

Briceño

et al. 2019

BioMed Research International

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Campylobacter spp., especially C. jejuni, are recognized worldwide as the bacterial species that most commonly cause food-related diarrhea. C. jejuni possesses many different virulence factors, has the ability to survive in different reservoirs, and has shown among isolates the emergence of Antimicrobial Resistance (AMR). Genome association analyses of this bacterial pathogen have contributed to a better understanding of its pathogenic and AMR associated determinants. However, the epidemiological information of these bacteria in Latin American countries is scarce and no genomic information is available in public databases from isolates in these countries. Considering this, the present study is aimed to describe the genomic traits from representative Campylobacter spp. strains recovered from faecal samples of patients with acute diarrhoea from Valparaíso, Chile. Campylobacter spp. was detected from the faeces of 28 (8%) out of 350 patients with acute diarrhoea, mainly from young adults and children, and 26 (93%) of the isolates corresponded to C. jejuni. 63% of the isolates were resistant to ciprofloxacin, 25.9% to tetracycline, and 3.5% to erythromycin. Three isolates were selected for WGS on the basis of their flaA-RFLP genotype. They belonged to the multilocus sequence typing (MLST) clonal clomplex (CC) 21(PUCV-1), CC-48 (PUCV-3), and CC-353 (PUCV-2) and presented several putative virulence genes, including the Type IV and Type VI Secretion Systems, as well as AMR-associated genes in agreement with their susceptibility pattern. On the basis of the wgMLST, they were linked to strains from poultry and ruminants. These are the first genomes of Chilean C. jejuni isolates available in public databases and they provide relevant information about the C. jejuni isolates associated with human infection in this country.

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Section: Discussionmentioning

confidence: 99%

Genomic Analysis of Chilean Strains ofCampylobacter jejunifrom Human Faeces

Levicán

Ramos-Tapia

Briceño

et al. 2019

BioMed Research International

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“…Some of these tests, such as fecal leukocytes, are widely available and inexpensive but have limited accuracy. 11, 12 Fecal calprotectin has the most robust data supporting its use as a predictor of impending disease flare in IBD patients during the subsequent 3 months, 10 with stool test sensitivity of 77% and specificity of 71% on the basis of results of a recent meta-analysis. 13 However, it is expensive, not universally available, and its ability to predict 6-month risk of flares is limited.…”

mentioning

confidence: 99%

Predicting Hospitalization and Outpatient Corticosteroid Use in Inflammatory Bowel Disease Patients Using Machine Learning

Waljee

Lipson

Wiitala

et al. 2017

Inflammatory Bowel Diseases

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“…7.2%. 34 Harris et al found an increase in the number of leukocytes in 3.6% UC patients and 7.2% in bacterial colitis patients. 32 Lugol's examination was performed to detect carbohydrate maldigestion and Sudan III examination to detect fat maldigestion.…”

Section: Discussionmentioning

confidence: 96%

Blood Zinc Profile and Fecal Analysis of Colitis Patients in Cipto Mangunkusumo General Hospital

Indrasari

Pattiasina

Fauzi

et al. 2022

InaJGHE

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Background: Colitis is a gastrointestinal disease that poses a major problem in Indonesia. Zinc (Zn) is an important trace element which plays role as antimicrobial in intestinal mucosa, increases gastrointestinal barrier, and immune function. Colitis can cause histologic changes in gastrointestinal tract epithelial which will disrupt the absorption and excretion of Zn causing zinc deficiency. This study aims to evaluate the difference of Zn level in colitis and healthy subjects, as well as the fecal analysis profile of colitis patients in Cipto Mangunkusumo General Hospital. Method: The design of this study was cross-sectional and was performed in colitis and healthy subjects. Colitis patients were recruited consecutively in patients in Gastroenterology Clinic and Gastrointestinal Endoscopy Centre in Cipto Mangunkusumo General Hospital. Zinc examination from blood sample was performed using spectrophotometry. Fecal analysis was performed manually. The level of zinc from colitis subjects was compared to healthy subjects. Fecal analysis examination consists of macroscopic, microscopic, and chemical examinations of the feces.Results: There were 40 colitis subjects and 16 healthy subjects in August 2019 - May 2020. There were significant differences in Zn levels between colitis and healthy subjects, which were 10.9 ± 1.9 mol/L and 12.3 ± 1 mol/L, respectively (p = 0.011). There were 45% (18/45) colitis subjects who were also suffering from Zn deficiency. The stool analysis in colitis subjects showed soft stool consistency in 90% subjects, slimy stools in 17.5%, increased in erythrocyte count in 60%, increased in leukocyte count in 5%, positive stool starch in 20%, positive stool fat in 7.5%, acid pH in 97.5%, positive stool occult blood in 37.5%, and fungi in stool in 7.5%.

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Diagnostic value of fecal leukocytes in chronic bowel diseases

Cited by 5 publications

References 6 publications

Genomic Analysis of Chilean Strains ofCampylobacter jejunifrom Human Faeces

Genomic Analysis of Chilean Strains ofCampylobacter jejunifrom Human Faeces

Predicting Hospitalization and Outpatient Corticosteroid Use in Inflammatory Bowel Disease Patients Using Machine Learning

Blood Zinc Profile and Fecal Analysis of Colitis Patients in Cipto Mangunkusumo General Hospital

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