Preliminary viability studies of fibroblastic cells cultured on microcrystalline and nanocrystalline diamonds produced by chemical vapour deposition method

Abstract

Implant materials used in orthopedics surgery have demonstrated some disadvantages, such as metallic corrosion processes, generation of wear particles, inflammation reactions and bone reabsorption in the implant region. The diamond produced through hot-filament chemical vapour deposition method is a new potential biomedical material due to its chemical inertness, extreme hardness and low coefficient of friction. In the present study we analysis two samples: the microcrystalline diamond and the nanocrystalline diamond. The aim of this study was to evaluate the surface properties of the diamond samples by scanning electron microscopy, Raman spectroscopy and atomic force microscopy. Cell viability and morphology were assessed using thiazolyl blue tetrazolium bromide, cytochemical assay and scanning electron microscopy, respectively. The results revealed that the two samples did not interfere in the cell viability, however the proliferation of fibroblasts cells observed was comparatively higher with the nanocrystalline diamond.

Development of Chitosan/Bacterial Cellulose Composite Films Containing Nanodiamonds as a Potential Flexible Platform for Wound Dressing

“…Multifunctional composite materials offer the amenity to achieve the required properties in a single platform [ 10 ]. For instance, although ND films prepared by chemical vapor deposition can promote the function of various biological entities and implantable devices [ 11 ], their practical applications are limited due to their high rigidity [ 1 ]. Therefore, there is an unmet need for the development of composite materials to overcome the mentioned challenge.…”

Fibroblast and pre-osteoblast cell adhesive behavior on titanium alloy coated with diamond film

“…Ideally, all parts and implants intended for use in human or veterinary medicine must be highly resistant to corrosion, fatigue and wear. Wear at the contact points is inevitable in prosthesis and implants, because of that, strategies to reduce its effects are being investigated 7 by using inert films as like nano and microcrystalline diamond films. In this regard, some studies show promising results with carbon-based films, such as diamond-like carbon 6,8 and diamond films 9 .…”