Characterization of the physical and mechanical properties of femoral bone defects filled with polyanionic collagen scaffolds in ovariectomized rats

Cunha, Marcelo Rodrigues da; Santos, Arnaldo Rodrigues; Petinari, Leandro; Góissis, Gilberto; Nonaka, Keico Okino; Wang, Charles Chenwei; Genari, Selma Candelária

doi:10.1590/s1516-14392010000200019

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…In addition, we noted the presence of trabecular bone in the implanted areas of group BOHR. Similar results have been reported by (Cho et al, 2004;Cunha et al, 2010), who studied the boneimplant interface in ovariectomized rats. The authors concluded that osteoporosis-like conditions induced by hormone deficiency might compromise the mechanical stability of the implant in view of the results demonstrating a reduction of the cortical layer and an increase of trabecular bone in the recipient area.…”

Section: Discussionsupporting

confidence: 89%

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Ribeiro

Figueira

Issa

et al. 2011

Microscopy Res & Technique

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2012Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats MICROSCOPY RESEARCH AND TECHNIQUE, MALDEN, v. 75, n. 2, pp. 133-137, FEB, 2012 http://www.producao.usp.br/handle/BDPI/42523 ABSTRACT Osteoporosis is a global public health that affects postmenopausal women due to the deficiency of estrogen, a hormone that plays an important role in the microarchitecture of bone tissue. Osteoporosis predisposes to pathological bone fracture that can be repaired by conventional methods. However, depending on the severity and quantity of bone loss, the use of autogenous grafts or biomaterials such as hydroxyapatite might be necessary. The latter has received increasing attention in the medical field because of its good biological properties such as osteoconductivity and biocompatibility with bone tissue. The objective of this study was to evaluate using histologic and radiographic analyses, the osteogenic capacity of hydroxyapatite implanted into the femur of rats with ovariectomy-induced osteoporosis. Eighteen rats were divided into three groups with six animals in each: group nonovariectomized, bilaterally ovariectomized not receiving estrogen replacement therapy, and bilaterally ovariectomized submitted to estrogen replacement therapy. Defects were created experimentally in the distal epiphysis of the femur with a surgical drill and filled with porous hydroxyapatite granules. The animals were sacrificed 8 weeks after surgery. The volume of newly formed bone in the implant area was quantified by morphometrical methods. The results were analyzed by ANOVA followed by the Tukey test (P < 0.05). The hydroxyapatite granules showed good radiopacity. Histological analysis revealed less quantity of newly formed bone in the ovariectomized group not submitted to hormone replacement therapy. In conclusion, bone neoformation can be expected even in bones compromised by estrogen deficiency, but the quantity and velocity of bone formation are lower. Microsc. Res. Tech. 75:133-137, 2012. V

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Section: Discussionsupporting

confidence: 89%

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Ribeiro

Figueira

Issa

et al. 2011

Microscopy Res & Technique

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“…At the end they reached the age of 15 weeks and so these normal physiological changes should be taken into account when interpreting the data. In previous works we have already reported that global food intake of our experimental animals was lower than in the control ones, as were body The physical characteristics of the femurs of the control rats were normal in terms of size, density and weight [26][27][28] (Table 1), whereas the femurs of the experimental rats were signicantly smaller in weight and volume, but similar in length. A signicant correlation between the femur weight and the nal body weight of the animals (r ¼ 0.650; P < 0.001) was found 18 which is in line with the observations of Fukuda and Iida 29 who reported that the growth period is the only stage during which body weight and BMD are closely correlated.…”

Section: Discussion 1 Composition and Physical Propertiesmentioning

confidence: 50%

“…The physical characteristics of the femurs of the control rats were normal in terms of size, density and weight [26][27][28] (Table 1), whereas the femurs of the experimental rats were signicantly smaller in weight and volume, but similar in length. A signicant correlation between the femur weight and the nal body weight of the animals (r ¼ 0.650; P < 0.001) was found 18 which is in line with the observations of Fukuda and Iida 29 who reported that the growth period is the only stage during which body weight and BMD are closely correlated.…”

Section: Discussion 1 Composition and Physical Propertiesmentioning

confidence: 99%

Composition and functionality of bone affected by dietary glycated compounds

et al. 2013

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Our aim was to investigate the effects of Maillard reaction products (MRPs) from bread crust (BC) on bone composition and its mechanical properties, determining whether any such effects are related to the molecular weight of different MRPs. For 88 days after weaning rats were fed a control diet or diets containing BC, or its soluble low molecular weight (LMW), soluble high molecular weight (HMW) or insoluble fractions. Animals' food consumption and body weights were monitored. After sacrifice, the femur, pelvic bone and tibia were removed for composition, physical and biomechanical properties analysis. It was found that body and femur weights, density, volume and organic matrix decreased, whereas pentosidine increased after consumption of experimental diets, especially in the HMW and insoluble groups (104.7 and 102.9 mmol mol(-1) collagen) vs. the control group (41.7 mmol mol(-1) collagen). Bone stiffness fell by 50% in the LMW, HMW and insoluble groups and failure load and energy to failure tended to decrease in the same animals after MRPs intake. Consumption of diets containing assayed MRPs during growth leads to lower bone size and introduces some changes in its mechanical behavior which appear to be related to an increase in the pentosidine level of bone.

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“…Physical parameters of the femurs, normal in terms of size, weight and density, are shown in Table . Femur weight, length, density and volume did not differ significantly between the groups, although the GL90 group showed lower values for all parameters.…”

Section: Resultsmentioning

confidence: 99%

Effects of model Maillard compounds on bone characteristics and functionality

et al. 2013

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Background Physical and biomechanical properties of bone can be affected by non‐enzymatic crosslinks, which are implicated in bone pathologies such as osteoporosis. The purpose of this study was to analyse the effects of the consumption of model Maillard reaction product (MRP) from glucose–lysine heated for 90 min at 150 °C (GL90) on bone composition and features. Rats were fed either a control diet or a diet containing 30 g kg−1 GL90 for 88 days. Food consumption and the animals' body weights were monitored. After sacrifice, the femur, pelvic bone and tibia were removed for analysis of their composition and physical and biomechanical properties. Results The organic matrix of the femur and the density of the pelvic bone decreased after MRP intake, whereas pentosidine content increased greatly with respect to the control group (41.7 ± 9.9 vs 171.4 ± 3.3 mmol mol−1 collagen). The rising level of C‐telopeptide degradation products from type I collagen (β‐CTX) suggested a possible situation of increased bone resorption and/or higher turnover. Conclusion In conjunction, the detrimental effect on the organic matrix, the situation of higher resorption and/or bone turnover indicated by the β‐CTX values and the high pentosidine content in bone provoked negative consequences on certain mechanical properties such as the ability to withstand force and absorb energy without failure. © 2013 Society of Chemical Industry

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Characterization of the physical and mechanical properties of femoral bone defects filled with polyanionic collagen scaffolds in ovariectomized rats

Cited by 5 publications

References 23 publications

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Study of the osteoconductive capacity of hydroxyapatite implanted into the femur of ovariectomized rats

Composition and functionality of bone affected by dietary glycated compounds

Effects of model Maillard compounds on bone characteristics and functionality

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