Avaliação toxicológica e efeito do extrato acetato de etila da fibra de Cocos nucifera L. (Palmae) sobre a resposta inflamatória in vivo

Silva, L.C.R.; Nunes-Pinheiro, D.C.S.; Morais, Selene Maia de; Lopes-Neto, Belarmino Eugênio; Santos, Glauco Jonas Lemos; Campello, C.C.

doi:10.1590/s1516-05722009000400011

Cited by 6 publications

(5 citation statements)

References 11 publications

(4 reference statements)

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“…Several studies have investigated the toxicological properties of C. nucifera. One paper verified the effect of ethyl acetate extract of C. nucifera fiber on physiological parameters and on topical inflammation induced by xylene in animal models ( 75 ). Regarding the physiological parameters and macroscopic aspects of the lymphoid organs in this study, neither mortality nor any symptom of toxicity was observed in the animals.…”

Section: Toxicitymentioning

confidence: 96%

Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review

Lima

Sousa

Meneses

et al. 2015

Braz J Med Biol Res

181

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Cocos nucifera (L.) (Arecaceae) is commonly called the “coconut tree” and is the most naturally widespread fruit plant on Earth. Throughout history, humans have used medicinal plants therapeutically, and minerals, plants, and animals have traditionally been the main sources of drugs. The constituents of C. nucifera have some biological effects, such as antihelminthic, anti-inflammatory, antinociceptive, antioxidant, antifungal, antimicrobial, and antitumor activities. Our objective in the present study was to review the phytochemical profile, pharmacological activities, and toxicology of C. nucifera to guide future preclinical and clinical studies using this plant. This systematic review consisted of searches performed using scientific databases such as Scopus, Science Direct, PubMed, SciVerse, and Scientific Electronic Library Online. Some uses of the plant were partially confirmed by previous studies demonstrating analgesic, antiarthritic, antibacterial, antipyretic, antihelminthic, antidiarrheal, and hypoglycemic activities. In addition, other properties such as antihypertensive, anti-inflammatory, antimicrobial, antioxidant, cardioprotective, antiseizure, cytotoxicity, hepatoprotective, vasodilation, nephroprotective, and anti-osteoporosis effects were also reported. Because each part of C. nucifera has different constituents, the pharmacological effects of the plant vary according to the part of the plant evaluated.

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Section: Toxicitymentioning

confidence: 96%

Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review

Lima

Sousa

Meneses

et al. 2015

Braz J Med Biol Res

181

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“…The histology of the spleen, a peripheral immune organ, was not modified, confirming the previous observations made with the crude extract . Moreover, an anti-inflammatory effect was noted with the ethyl acetate extract of Cocos nucifera fiber following a local inflammation induction by xylene in animal experiments (Silva et al, 2009 …”

mentioning

confidence: 88%

Safety of Ethyl Acetate Fraction of Cocos Nucifera Root Extract.

Sènou¹,

Tchogou²,

Dougnon³

et al. 2017

IJAR

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1083Cocos nucifera is a tropical coastal plant. The ethyl acetate fraction of its aqueous root extract stimulates erythropoiesis. This work aimed to evaluate the biological tolerance of this fraction. The extract fraction was administered to Wistar rats at a single dose of 2000 mg / kg body weight for Acute Oral Toxicity (OAT) or in daily doses of 200 mg / kg body weight for 28 days for Sub-Chronic Toxicity. (SCT), as recommended by the OECD. On day 0, then on day 14 for OAT and day 28 for SCT, the rats were weighed and their blood was collected for tests. The liver balance was assessed by measuring transaminases AST and ALT, kidney balance by uremia and creatinine level and immune status by blood leukocyte count. These analyzes were supplemented by the histology of the liver, kidneys and spleen, an immune organ. The weight of rats, the balance of liver, kidney and immunity as well as these organs histology were not affected by either acute oral or sub-chronic toxicity tests, suggesting a lack of toxicity in the extract fraction. The ethyl acetate fraction of the root water extract of Cocos nucifera did not reveal any acute or sub-chronic oral toxicity. This effect could be related to its richness in flavonoids that are antioxidants. The study of biological tolerance deserves to be continued by the chronic toxicity test and clinical trials.

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“…The activity is due to the ability to form complexes with soluble extracellular proteins that bind to the cell wall of the bacteria. Several studies have shown that flavonoid compounds such as flavonones, flavononols, flavonols and also bioflavonoids (xanthones) exhibit this antimicrobial activity, as well as antiviral, anti-ulcerogenic, anti-hepatotoxic, hypolipidemic, antineoplastic, anti-allergic and anti-inflammatory activities [22].…”

Section: Discussionmentioning

confidence: 99%