Fluoride varnishes play an important role in the prevention of dental caries,
promoting the inhibition of demineralization and the increase of
remineralization.Objective This study aimed to analyze the amount of fluoride released into water and
artificial saliva from experimental TiF4 and NaF varnishes, with
different concentrations, for 12 h. Material and Methods Fluoride varnishes were applied on acrylic blocks and then immersed in 10 ml of
deionized water and artificial saliva in polystyrene bottles. The acrylic blocks
were divided in seven groups (n=10): 1.55% TiF4 varnish (0.95% F, pH
1.0); 3.10% TiF4 varnish (1.90% F, pH 1.0); 3.10% and 4% TiF4
varnish (2.45% F, pH 1.0); 2.10% NaF varnish (0.95% F, pH 5.0); 4.20% NaF
varnish (1.90% F, pH 5.0); 5.42% NaF varnish (2.45% F, pH 5.0) and control (no
treatment, n=5). The fluoride release was analyzed after 1/2, 1, 3, 6, 9 and 12 h
of exposure. The analysis was performed using an ion-specific electrode coupled to
a potentiometer. Two-way ANOVA and Bonferroni's test were applied for the
statistical analysis (p<0.05). Results TiF4 varnishes released larger amounts of fluoride than NaF varnishes
during the first 1/2 h, regardless of their concentration; 4% TiF4
varnish released more fluoride than NaF varnishes for the first 6 h. The peak of
fluoride release occurred at 3 h. There was a better dose-response relationship
among the varnishes exposed to water than to artificial saliva. Conclusions The 3.10% and 4% TiF4 -based varnishes have greater ability to release
fluoride into water and artificial saliva compared to NaF varnish; however, more
studies must be conducted to elucidate the mechanism of action of TiF4
varnish on tooth surface.