Estudo Pró-Saúde: observações adicionais sobre temas e métodos

Faerstein, Eduardo; Chor, Dóra; Lopes, Cláudia de Souza; Werneck, Guilherme Loureiro

doi:10.1590/s1415-790x2005000400017

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…The Pro-Saude study has been described before (Faerstein et al 2005). Civil servants at university campuses in the State of Rio de Janeiro, Brazil, were invited to participate in this cohort study.…”

Section: Methodsmentioning

confidence: 99%

The risk of diabetes associated with DDE exposure and its interaction with a common FTO gene variant: the Pro-Saude study, Brazil

Meyer,

Sichieri,

Porta

et al. 2024

Preprint

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Exposure to dichlorodiphenyldichloroethylene (DDE) is suspected to be associated with an increased risk of type 2 diabetes (T2D). Other studies suggested that the fat mass and obesity-associated gene (FTO) is associated with T2D risk, regardless of adiposity. Dichlorodiphenyltrichloroethane (DDT) was used in Brazil until the mid-2000s, but no previous studies investigated the association between diabetes and body concentrations of DDE in that country. We investigated that association in a population of Rio de Janeiro, as well as how the FTO-rs9939609 genotypes might affect it. In this cross-sectional study nested in the Pro-Saude cohort, participants were randomly selected according to age, sex, and educational level at the cohort's baseline up to n = 520. Individuals who self-reported diabetes or presented glycated hemoglobin (HbA1c) ≥ 6.5% in the study's phase 4 were considered diabetic. We used logistic regression to estimate the odds ratio of diabetes according to serum levels of DDE, adjusting for age, sex, and total fat mass. We stratified the adjusted odds ratio by FTO-rs9939609 variant genotypes. Serum levels of DDE were associated with a higher chance of having diabetes (OR: 1.43; 95%CI: 1.11–1.84). Across quartiles of DDE concentrations, the dose-response relationship was statistically significant (p-trend = 0.003). The magnitude of the association was higher among individuals with the homozygous allele for the FTO-rs9939609 gene (OR: 3.33; 0.45–24.13). Exposure to DDE may increase the risk of developing diabetes in the Brazilian population, especially in individuals homozygous allele for the FTO-rs9939609 variant.

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Section: Methodsmentioning

confidence: 99%

The risk of diabetes associated with DDE exposure and its interaction with a common FTO gene variant: the Pro-Saude study, Brazil

Meyer,

Sichieri,

Porta

et al. 2024

Preprint

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“…Experiences of racial discrimination will be evaluated by applying a questionnaire elaborated by Krieger [ 43 ] and used in the CARDIA [ 44 ] and the PRÓ-SAÚDE study in Brazil [ 45 ].…”

Section: Methodsmentioning

confidence: 99%

“…Social support and social support network will be evaluated using the social support scale of the Medical Outcomes Study (MOS). The scale was translated and adapted to Portuguese and later validated and used in the Pró-Saúde study on a cohort of employees of a Brazilian public University [ 46 , 45 ]. Greater social support will be considered to be present when the replies are above the 75 th percentile.…”

Section: Methodsmentioning

confidence: 99%

A protocol to identify non-classical risk factors for preterm births: the Brazilian Ribeirão Preto and São Luís prenatal cohort (BRISA)

et al. 2014

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BackgroundPreterm birth is the main cause of morbidity and mortality during the perinatal period. Classical risk factors are held responsible for only 1/3 of preterm births and no current intervention has produced an appreciable reduction of this event. It is necessary to explore new hypotheses and mechanisms of causality by using an integrated approach, collaboration among research groups and less fragmented theoretical-methodological approaches in order to detect new risk factors and to formulate more effective intervention strategies.MethodsThe study will be conducted on a convenience cohort of Brazilian pregnant women recruited at public and private prenatal health services. A total of 1500 pregnant women in São Luís, and 1500 in Ribeirão Preto, will be invited for an interview and for the collection of biological specimens from the 22nd to the 25th week of gestational age (GA). At the time of delivery they will be reinterviewed. GA will be determined using an algorithm based on two criteria: date of last menstruation (DLM) and obstetric ultrasound (OUS) performed at less than 20 weeks of GA. Illicit drug consumption during pregnancy will be determined using a self-applied questionnaire and the following instruments will be used: perceived stress scale, Beck anxiety scale, screening for depression of the Center of Epidemiological Studies (CES-D), experiences of racial discrimination, social network and social support scale of the Medical Outcomes Study and violence (Abuse Assessment Screening and violence questionnaire of the WHO). Bacterial vaginosis, urinary tract infection and periodontal disease will also be identified. Neuroendocrine, immunoinflammatory and medical intervention hypotheses will be tested. The occurrence of elective cesarean section in the absence of labor will be used as a marker of medical intervention.ConclusionPsychosocial, genetic and infectious mechanisms will be selected, since there are indications that they influence preterm birth (PTB). The studies will be conducted in two Brazilian cities with discrepant socioeconomic conditions. The expectation is to identify risk factors for PTB having a greater predictive power than classically studied factors. The final objective is to propose more effective interventions for the reduction of PTB, which, after being tested, might subsidize health policies.Electronic supplementary materialThe online version of this article (doi:10.1186/1742-4755-11-79) contains supplementary material, which is available to authorized users.

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The role of potential mediators in racial inequalities in tooth loss: the Pró‐Saúde study

Celeste

Gonçalves

Faerstein

et al. 2013

Comm Dent Oral Epid

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Estudo Pró-Saúde: observações adicionais sobre temas e métodos

Cited by 3 publications

References 4 publications

The risk of diabetes associated with DDE exposure and its interaction with a common FTO gene variant: the Pro-Saude study, Brazil

The risk of diabetes associated with DDE exposure and its interaction with a common FTO gene variant: the Pro-Saude study, Brazil

A protocol to identify non-classical risk factors for preterm births: the Brazilian Ribeirão Preto and São Luís prenatal cohort (BRISA)

The role of potential mediators in racial inequalities in tooth loss: the Pró‐Saúde study

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