Efeito hipolipidêmico do suco de camu-camu em ratos

Schwertz, M.C.; Maia, Jeniffer Resende Patrocínio; Sousa, Risonilce F. S; Aguiar, Jaime Paiva Lopes; Yuyama, Lúcia Kiyoko Ozaki; Lima, Émerson Silva

doi:10.1590/s1415-52732012000100004

Cited by 15 publications

(8 citation statements)

References 19 publications

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“…Regarding in vivo studies, Yazawa et al [124] studied the methanolic extracts of camu-camu seeds, and found anti-inflammatory action in carrageenan-induced paw oedema in murine models. Studies of camu-camu pulp are more frequently found in the literature [125,126,127,128,129]. However, it was stressed to use the waste that is generated while obtaining the pulp.…”

Section: Fruit By-products (Seeds): Chemical Characterization and mentioning

confidence: 99%

Fruit Seeds as Sources of Bioactive Compounds: Sustainable Production of High Value-Added Ingredients from By-Products within Circular Economy

et al. 2019

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The circular economy is an umbrella concept that applies different mechanisms aiming to minimize waste generation, thus decoupling economic growth from natural resources. Each year, an estimated one-third of all food produced is wasted; this is equivalent to 1.3 billion tons of food, which is worth around US$1 trillion or even $2.6 trillion when social and economic costs are included. In the fruit and vegetable sector, 45% of the total produced amount is lost in the production (post-harvest, processing, and distribution) and consumption chains. Therefore, it is necessary to find new technological and environmentally friendly solutions to utilize fruit wastes as new raw materials to develop and scale up the production of high value-added products and ingredients. Considering that the production and consumption of fruits has increased in the last years and following the need to find the sustainable use of different fruit side streams, this work aimed to describe the chemical composition and bioactivity of different fruit seeds consumed worldwide. A comprehensive focus is given on the extraction techniques of water-soluble and lipophilic compounds and in vitro/in vivo functionalities, and the link between chemical composition and observed activity is holistically explained.

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Section: Fruit By-products (Seeds): Chemical Characterization and mentioning

confidence: 99%

Fruit Seeds as Sources of Bioactive Compounds: Sustainable Production of High Value-Added Ingredients from By-Products within Circular Economy

et al. 2019

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“…Experiments with animal models and humans have demonstrated the hypolipidemic and anti-obesity activities of camu-camu. Dyslipidemic rats treated for 14 days with fruit juice of camu-camu showed a reduction in triacylglycerols and total cholesterol in a dose-dependent manner as well as significant reduction in body weight [19]. Similarly, in a diet-induced obesity rat model treated daily with the fruit juice of camu-camu pulp resulted in a significant loss of body weight, reduction in blood levels of triacylglycerols, total cholesterol, LDL cholesterol, and VLDL cholesterol, while HDL cholesterol was increased [54].…”

Section: Hypolipidemic and Anti-obesity Activitiesmentioning

confidence: 96%

“…[2,[8][9][10], and within that last decade, studies determined the fruits (exocarp, mesocarp, and endocarp) and several other tissues/organs (barks, leaves, roots) are a rich source of a wide diversity of health-promoting phytochemicals. These healthpromoting phytochemicals possess potent antioxidant, anti-inflammatory, hypolipidemic, anti-obesity, hypoglycemic, antidiabetic, neuroprotective, hepatoprotective, antihypertensive, anticancer, antibacterial, and antiprotozoal activities [11][12][13][14][15][16][17][18][19]. All these health-beneficial activities were verified by various in vitro and in vivo studies and evidence from human clinical trials [18,[20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds of Camu-Camu (Myrciaria dubia (Kunth) McVaugh)

Castro

Maddox

Cobos³

et al. 2019

Reference Series in Phytochemistry

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Camu-camu is a shrub, native to the Amazon that thrives in areas where flooding is frequent. Genetically, the plant is characterized by a diploid genome and moderate genetic diversity. Several parts of the plant are used in traditional folk medicine to treat a variety of acute and chronic diseases. For over 50 years, the exceptionally high vitamin C content of camu-camu has attracted worldwide attention that continues today because of the recent discovery of several healthpromoting phytochemicals with corroborated biological activities (e.g., antioxidant, anti-obesity, antidiabetic). All of these beneficial attributes are well supported by in vitro and in vivo studies as well as human clinical trials. The metabolic precursors of these phytochemicals are synthesized in key metabolic pathways (i.e., the shikimate pathway, the mevalonate pathway). Of these metabolic pathways, we show details for the biosynthesis of betulinic acid, transresveratrol, and syringic acid. In conclusion, camu-camu is an exceptional plant for its ability to produce and accumulate significant amounts of a variety of health-promoting phytochemicals. Although several metabolic pathways responsible for the biosynthesis of these phytochemicals have been reconstructed based on fruit and seedling transcriptomes, detailed knowledge of the vast majority of metabolic pathways and their molecular regulatory mechanisms is lacking. Consequently, we must increase our knowledge of the metabolic processes using multi-omic approaches so that we can acquire the skills necessary to develop genetically improved varieties of camu-camu and implement biotechnological applications for the production of these bioactive phytochemicals.

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“…19 O camu-camu vem ganhando espaço na pesquisa por ser uma fruta rica em ácido ascórbico, flavonoides e ser fonte de minerais. 20 Em estudos realizados com camucamu produzidos em Roraima foram identificados na casca a presença de Ca, Mg, Zn, Fe, Mn, Cu e K. 21 A caracterização física e química de duas amostras destes materiais, cascas e sementes, descartados durante um processo de avaliação em laboratório obtiveram, teor de água variando de 5,45 a 5,67 %, pH com variação de 6,7 a 7,6 e índice médio de acidez em torno de 0,02g.100g -1 de ácido cítrico, considerando que o material tem potencial para o desenvolvimento de novas tecnologias com possibilidade de uso na agricultura de pequeno porte. 22…”

Section: Amostrasunclassified

Minerals in Aqueous Extract of the Coproducts Myrciaria dubia (Kunth.) McVaugh, Myrtaceae

Sousa¹,

Chagas²,

Guimarães³

et al. 2015

Revista Virtual De Química

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The camu-camu of fruits (Myrciaria dubia (HBK) McVaugh, Myrtaceae) arising from Amazonia, are considered a major source of vitamin C in the world. There are still important sources of different bioactive compounds and good source of minerals such as sodium, potassium, calcium, zinc, magnesium, manganese and copper. However, the processing of these fruits for extraction of the pulp, the product of greatest interest to many consumption, creates an effective quantity of different wastes, solid and liquid, capable of utilization for various uses its technological potential is studied. Thus, this work aimed at determining, quickly, via direct condutometric electroanalytical method, the amount of dissolved minerals contained in the aqueous extract of processed seeds and peels, coproducts of Myrciaria dubia, with potential use in the area of biotechnology development. The samples used for the study come from the experimental processing of fruit camu-camu. Three coproducts (byproducts/waste) named: CF, CS and SSC also processed via Standard Operating Procedure (SOP) created in our own laboratory for the study of organic waste. Analyzing the results obtained it was found that the samples CF and SSC showed higher electrical conductivity, which characterizes them as a rich source of electrolytes, showing greater ability to exchange ions to the solution, which can be characterized as a nutrient solution. Conductivity values obtained from samples from CF, CS and SSC outweigh some brands of bottled water sold in the Brazilian market, ranging from 32 to 72% when compared to the highest value obtained, 408,0 S.cm-1 at 25°C, considered as a nutrient solution of high value rich in minerals. The conductometry technique was effective for rapid determination of total dissolved coproducts of processed fruit samples camu-camu minerals. It also made possible by the high mineral contents, characterize them as nutrient solution, with potential for exploitation in the area of biotechnology development.

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Efeito hipolipidêmico do suco de camu-camu em ratos

Cited by 15 publications

References 19 publications

Fruit Seeds as Sources of Bioactive Compounds: Sustainable Production of High Value-Added Ingredients from By-Products within Circular Economy

Fruit Seeds as Sources of Bioactive Compounds: Sustainable Production of High Value-Added Ingredients from By-Products within Circular Economy

Bioactive Compounds of Camu-Camu (Myrciaria dubia (Kunth) McVaugh)

Minerals in Aqueous Extract of the Coproducts Myrciaria dubia (Kunth.) McVaugh, Myrtaceae

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