Omega-3 fatty acids reduce the development of preneoplasic lesions

Abstract

OBJECTIVE: The purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats. METHODS: A total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography. RESULTS: The omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28. CONCLUSION: These results suggest that omega-3 may slow the progress of colorectal carcinogenesis.

Chemopreventive and metabolic effects of inulin on colon cancer development

“…Dietary intake was recorded daily and animal weights were measured weekly. The food intake efficiency rate (FER) was estimated with the formula: FER = (final weight-initial weight)/ average dietary intake [ 10 ]. After 28 weeks of consuming the experimental diets, the animals were euthanized under anesthesia (100 mg ketamin/kg body weight with 15 mg xylazin/kg body weight, intraperitoneal).…”