Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population

Abstract

The transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2 diabetes patients (N = 258) and normal healthy control subjects (N = 168) from the same area, were examined. The ARMS- PCR (Amplification Refractory Mutation System) technique, subsequently validated by direct sequencing, was used for genotyping. Allele and genotype frequencies were significantly different between patients and controls TT vs. CT + CC [p 0.0081 OR 3.4 95%CI (1.27-11.9)] and T vs. C allele [p 0.02 OR 1.4 95%CI (1.03-1.9)]. Our data thus confirm the association between the rs7903146 T allele and T2D in an Iranian population, contrary to previous reports in Arab populations. This can possibly be attributed to differences in ethnic background or the effects of environmental factors.

Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India

“…These three SNPs, individually and/or as a group, were found to be associated with T2DM in a wide spectrum of world populations: Finnish [19], Amish [20], U.S [21], Polish [22], Scandinavian [23], Chinese [24], Brazil [25], Japanese[26]–[28], Swedish [29], U.K [30], Dutch [31], Palestinian [32], Iranian [33], [34], Arab [35], Tunisian [36], Persian [37] as well as Indian populations [13]–[17]. Of the three SNPs, rs7903146 is the most consistent in several GWAS studies [5], [38]–[45] as well as most replicated variant of TCF7L2.…”

Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population

“…Most published epidemiological studies have placed emphasis on rs7903146 (C/T) and rs12255372 (G/T) variations (Luo et al , 2009; Tong et al , 2009), with the consequential association of rs7903146 TCF7L2 polymorphism with T2DM (Amoli et al , 2010). …”

Evaluation of Transcription Factor 7 like 2 polymorphisms and haplotypes in risk of Type 2 Diabetes

“…The results showed that GC and CC genotypes of rs11196205 of TCF7L2 gene were strongly associated with T2D as risk factor, and C allele of this gene SNP (rs4132670) was not associated with T2D. However, previous studies have proved that rs7903146C/T polymorphism of TCF7L2 is associated with T2D in different ethnic populations (12)(13)(14)(15). There is little data regarding the role of TCF7L2 polymorphism (rs11196205 and rs4132670), especially rs4132670 polymorphism.…”