Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population

Abstract

In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. The PCR-RFLP method was used for genotyping rs12255372 (G/T) polymorphism, and the SPSS version 18.0 for Windows for statistical analysis. The minor T allele of TCF7L2 rs12255372 was found to significantly increase the risk of T2DM, with an allelic odds ratio (OR) of 1.458 (95% CI 1.108–1.918, p = 0.007). A significant difference in TT genotype was observed between T2DM patients and normoglycemic controls (OR 2.038, 95% CI 1.147–3.623; p = 0.014). On assuming dominant and recessive models, ORs of 1.52 [95% CI (1.05–2.21) p = 0.026)] and 1.74 [95% CI (1.01–3.00) p = 0.043] were obtained, respectively, thereby implying that the co-dominant model would best fit the susceptible gene effect. This study further confirms the TCF7L2 gene as enhancing susceptibility to the development of T2DM.

<p><em>SLC30A8, CDKAL1, TCF7L2, KCNQ1</em> and <em>IGF2BP2</em> are Associated with Type 2 Diabetes Mellitus in Iranian Patients</p>

“…Of 31 provinces in Iran, studies on only two provinces, Gorgan 50 and Kurdish, 51 revealed that the frequency of the TCF7L2 rs7903146 polymorphism was significant, which is in agreement with present study. In contrast to our study, a lack of remarkable association between TCF7L2 rs7903146 polymorphism and T2D was reported among the Arabian Emirates 52 and Saudi Arab population.…”

Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies

“…However no data from Iranian population as a type of Asian population was included in this meta-analysis [ 111 ]. In line with these data, in our study, we found a positive association between rs12255372 and rs7903146 variants of TCF7L2 and T2DM [ 38 , 48 , 53 ].…”

“…Association between two polymorphisms of TCF7L2 including rs7903146 (C/T) and rs12255372 (G/T) was assessed in three studies [ 38 , 48 , 53 ]. In one study investigating rs7903146 (C/T) in 466 subjects, significant difference in the frequency of CC and CT genotypes was observed between T2DM and control group ( P = 0.045) [ 38 ].…”

“…However in another study this polymorphism showed a positive significant association with TT genotype in T2DM ( P = 0.008) [ 53 ]. Investigation of rs12255372 (G/T) polymorphism of TCF7L2 in another study showed that among 491 subjects there was a positive significant association between TT carriers and T2DM ( P = 0.014) [ 48 ].…”

Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India

“…These three SNPs, individually and/or as a group, were found to be associated with T2DM in a wide spectrum of world populations: Finnish [19], Amish [20], U.S [21], Polish [22], Scandinavian [23], Chinese [24], Brazil [25], Japanese[26]–[28], Swedish [29], U.K [30], Dutch [31], Palestinian [32], Iranian [33], [34], Arab [35], Tunisian [36], Persian [37] as well as Indian populations [13]–[17]. Of the three SNPs, rs7903146 is the most consistent in several GWAS studies [5], [38]–[45] as well as most replicated variant of TCF7L2.…”