Valongo, genetic studies on an isolated Afro-Brazilian community

Souza, Ilíada Rainha de; Culpi, L.

doi:10.1590/s1415-47572005000300012

Cited by 9 publications

(8 citation statements)

References 8 publications

(6 reference statements)

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“…Comparing our results to other Brazilian African‐derived populations, the contribution of African genes in quilombo populations from Vale do Ribeira (39.7%) is lower than in African‐derived populations of Southern (Bortolini et al,1999; Souza and Culpi,2005), Northeastern (Arpini‐Sampaio et al,1999; Bortolini et al,1999) and Northern (Bortolini et al,1995, 1999; Cayres‐Vallinoto et al,2003; Guerreiro et al,1999; Lopes Maciel et al,2011) Brazil, estimated on different sets of autosomal markers. In only one study (Lopes Maciel et al,2011) the same panel of autosomal INDEL markers was employed.…”

Section: Resultssupporting

confidence: 42%

Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancer

Hegel

Moore

Collins

et al. 2006

Cancer

257

177

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Objectives: xMany Africans were brought to Brazil as slaves. The runaway or abandoned slaves founded isolated communities named quilombos. There are many quilombo remnants in Vale do Ribeira region in the southern part of São Paulo State. The aim of our study was to contribute to understanding the origins of these populations, through admixture studies. Methods: We genotyped 307 unrelated DNA samples obtained from ten quilombo populations from Vale do Ribeira region, using a panel of 48 INDEL polymorphisms. We estimated genetic differentiation between populations (FST) and genomic ancestry from these populations. Our data were compared to a similar study performed in quilombo remnants from the Brazilian Amazon region. Results: Population admixture estimates showed high degree of miscegenation in the quilombo remnants from Vale do Ribeira (average admixture estimates at 39.7% of African, 39.0% of European and 21.3% of Amerindian contribution). The proportions of ancestral genes varied greatly among individuals, ranging from 7.3 to 69.5%, 12.9 to 68.3%, and 7.3 to 58.5% (African, European, and Amerindian, respectively). Genetic differentiation between these populations was low (all FST values <5%), indicating gene flow between them. Both groups of quilombos, from Vale do Ribeira and Amazon, presented similar patterns of admixture. Conclusions: INDEL markers were useful to evidence the triple interbreeding among African, European, and Amerindian in the formation of quilombo populations. The low FST values suggested gene flow among quilombos from Vale do Ribeira. Our data highlight the important role of Amerindians in the formation of quilombo populations. Am. J. Hum. Biol., 2013. © 2012 Wiley Periodicals, Inc.

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Section: Resultssupporting

confidence: 42%

Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancer

Hegel

Moore

Collins

et al. 2006

Cancer

257

177

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“…However, the high contribution of Amerindian genes in Afro-derived communities is not common in other regions of Brazil. Other researchers have reported a small contribution of Amerindian autosomal genes (less than 10%) in the South (Bortolini et al 1995;Souza and Culpi 2005), in the Central-West and the Northeast of Brazil (Silva Jr. et al 1999).…”

Section: Differentiation Between Populationsmentioning

confidence: 93%

“…The greatest contribution of Amerindian genes was found in the Pacoval (32%) and Marajó (31%) communities and the lowest in Pontal (13%). The whole estimated population contributions are: African genes, 48.5%; Europeans,28.9%;and Amerindians,22.6%. Comparing the data obtained from the autosomal markers in the Amazonian Afro-derived populations and other Brazilian Afro-derived populations, it is possible to see that the Amazonian populations have a lower contribution of African genes than the Afro-derived populations of south (mean of 69%) and northeast (mean of 62%) of Brazil (Bortolini et al 1995;Bortolini et al 1998;Bortolini et al 1999;Souza and Culpi 2005).…”

Section: Differentiation Between Populationsmentioning

confidence: 99%

Afro-Derived Amazonian Populations: Inferring Continental Ancestry and Population Substructure

et al. 2011

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A panel of Ancestry Informative Markers (AIMs) was used to identify population substructure and estimate individual and overall interethnic admixture in 294 individuals from seven African-derived communities of the Brazilian Amazon. A panel of 48 biallelic markers, representing the insertion (IN) or the deletion (DEL) of small DNA fragments, was employed for this purpose. Overall interethnic admixture estimates showed high miscegenation with other ethnic groups in all populations (between 46% and 64%). The proportion of ancestral genes varied significantly among individuals of the sample: the contribution of African genes varied between 12% and 75%; of European genes between 10% and 73%; and of Amerindians genes between 8% and 66%. The obtained data reveal a high contribution of Amerindian genes in these communities, unlike in other African-derived communities of the Northeast and the South of Brazil. In addition, the majority of the Amerindian contribution may result from the preferential inclusion of indigenous women in the African descent groups. High heterogeneity of the proportion of interethnic admixture among analyzed individuals was found when the proportion of ancestral genes of each individual of the sample was estimated. This heterogeneity is reflected in the fact that four populations can be considered as substructured and that the global African descent sample is possibly formed by two subpopulations. 46% and 64%). The proportion of ancestral genes varied significantly among individuals of the sample: the contribution of African genes varied between 12% and 75%; of European genes between 10% and 73%; and of Amerindians genes between 8% and 66%. The obtained data reveal a high contribution of Amerindian genes in these communities, unlike in other African-derived communities of the Northeast and the South of Brazil. In addition, the majority of the Amerindian contribution may result from the preferential inclusion of indigenous women in the African descent groups. High heterogeneity of the proportion of interethnic admixture among analyzed individuals was found when the proportion of ancestral genes of each individual of the sample was estimated. This heterogeneity is reflected in the fact that four populations can be considered as substructured and that the global African descent sample is possibly formed by two subpopulations. Keywords AMAZON, AIM, AFRICAN DESCENT, INDEL, POPULATION SUBSTRUCTUREThe Brazilian population is the product of the miscegenation of three main ethnic groups: Amerindians, Europeans, and Africans. It is estimated that approximately four million Africans were brought by force to Brazil as slaves between 1550 and 1870 (Klein 1986). The distinct geographical regions of Brazil received different numbers of African slaves, being greater in the Northeast and lower in the North (Santos and Guerreiro 1995). The arrival of African slaves to the Amazon began in the mid-17th century (1750). It is estimated that at least 53,000 Africans arrived in the Brazilian Amazon during the ...

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“…For instance, the Valango quilombo community in Southern Brazil is almost entirely of African ancestry (97.3%) (Souza and Culpi, 2005). Despite this, they display more heterogeneity, when compared to other isolated communities.…”

Section: Discussionmentioning

confidence: 99%

Genomic ancestry evaluated by ancestry-informative markers in patients with sickle cell disease

et al. 2016

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Valongo, genetic studies on an isolated Afro-Brazilian community

Cited by 9 publications

References 8 publications

Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancer

Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancer

Afro-Derived Amazonian Populations: Inferring Continental Ancestry and Population Substructure

Genomic ancestry evaluated by ancestry-informative markers in patients with sickle cell disease

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