Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced chromosomal aberrations in CHO cells

Antunes, Lusânia Maria Greggi; Araújo, Maria Cristina P.; Dias, Francisca da Luz; Takahashi, Catarina Satie

doi:10.1590/s1415-47572005000100028

Cited by 12 publications

(6 citation statements)

References 19 publications

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“…Downregulation of various inflammatory cytokines such as TNF, interleukin (IL)-1, IL-6, IL-8, interferon, and some other chemokines are also carried by the circumin. [ 13 ] Considering the anti-inflammatory effect of turmeric and chlorhexidine mouthwash, the results of the present study were consistent with the results of Waghmare et al .,[ 14 ] Van der Weijden et al .,[ 15 ] Grundemann et al .,[ 16 ] and Leyes, et al . [ 17 ] The progression of disease progression was markedly reduced by the activity of curcumin as pro-oxidant and antioxidant by scavenging the free radical, a reducing agent and a DNA damage inhibitor.…”

Section: Discussionmentioning

confidence: 99%

A comparative evaluation of the efficacy of curcumin and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A double-blinded randomized controlled clinical study

Chatterjee¹,

Debnath²,

Rao³

2017

J Indian Soc Periodontol

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Aim:The aim of this study was to assess the efficacy of 0.1% curcumin mouthwash and to compare it with 0.2% chlorhexidine gluconate as an antiplaque agent and its effect on gingival inflammation.Materials and Methods:One hundred and fifty subjects, age between 20 and 30 years were recruited. Study population were randomly divided into three groups. In Group A, 50 subjects were advised the experimental mouthwash. Group B subjects used placebo mouthrinse, and chlorhexidine mouth wash was given to Group C. The subjects were advised to use 10 ml of mouthwash for 1 min twice a day 30 min after brushing. Parameters were recorded for plaque, gingival, and sulcus bleeding indices at day 0, 7, 14, and 28 days along with subjective assessment of taste.Results:On intragroup comparison between curcumin, chlorhexidine, and placebo mouthwash, the mean percentage reduction of the plaque index (PI) between 0 and 28 days were 0.58,0.57 and 1.17, respectively (P < 0.01), percentage reduction of gingival index (GI) between 0 and 28 days were 0.65, 0.66, and 1.09, respectively (P < 0.01) and sulcus bleeding index (SBI) showed a percentage reduction of 0.69, 0.66, and 1.13, respectively The intergroup comparison revealed chlorhexidine and curcumin mouthwash were statistically significant with P < 0.001 as compared to placebo.Conclusion:Curcumin mouthwash has shown an antiplaque and antigingivitis properties comparable to chlorhexidine mouthwash. Thus, curcumin mouthwash and chlorhexidine gluconate can be effectively used as an adjunct to scaling and root planning.

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Section: Discussionmentioning

confidence: 99%

A comparative evaluation of the efficacy of curcumin and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A double-blinded randomized controlled clinical study

Chatterjee¹,

Debnath²,

Rao³

2017

J Indian Soc Periodontol

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“…Although it is well established that curcumin is able to bind Fe, Mn and Cu as described above, there are relatively few studies of how such binding modulates the redox properties of curcumin. Studies involving the interaction of curcumin with Fe or Cu have indicated pro-oxidant effects, suggesting that the metal complexes are able to redox cycle, in analogy to the Fenton process [176,183,184]. Radicalscavenging effects are also noted for the Mn [172] and Cu [177] complexes of curcumin, either of hydroxyl radical or of superoxide.…”

Section: Redox Chemistrymentioning

confidence: 99%

Curcumin: From ancient medicine to current clinical trials

Hatcher

Planalp

Cho

et al. 2008

Cell. Mol. Life Sci.

1,631

1,159

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Abstract. Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. The pleiotropic activities of curcumin derive from its complex chemistry as well as its ability to influence multiple signaling pathways, including survival pathways such as those regulated by NF-kB, Akt, and growth factors; cytoprotective pathways dependent on Nrf2; and metastatic and angiogenic pathways. Curcumin is a free radical scavenger and hydrogen donor, and exhibits both pro-and antioxidant activity. It also binds metals, particularly iron and copper, and can function as an iron chelator. Curcumin is remarkably non-toxic and exhibits limited bioavailability. Curcumin exhibits great promise as a therapeutic agent, and is currently in human clinical trials for a variety of conditions, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis and Alzheimers disease.

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“…The biological classification of curcumin as both pro-oxidant and antioxidant, is well supported by studies showing curcumin as a free radical scavenger, a reducing agent, and a DNA damage inhibitor, especially in the presence of Cu or Fe ions. Curcumin is able to bind to Fe, Mn and Cu that was reported to modulate the antioxidant properties [54][55][56] and radical scavenging effects [57,58] of this agent. In vitro studies have shown that curcumin inhibits nitric oxide and reactive oxygen species (ROS) production in macrophages [59,60]; it also inhibits lipo-oxygenase as well as cyclooxigenase in fibroblast cells of rats [61].…”

Section: Antioxidative Activity Of Curcuminmentioning

confidence: 99%

A Review of Therapeutic Effects of Curcumin

Noorafshan

Ashkani-Esfahani²

2013

CPD

122

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There is a growing interest in herbal medicine. Scientific studies have demonstrated the beneficial pharmacological effects of curcumin. Curcumin is a bright yellow spice, derived from the rhizome of Curcuma longa Linn. It has been proven that curcumin is a highly pleiotropic molecule which can be a modulator of intracellular signaling pathways that control cell growth, inflammation, and apoptosis. Curcumin might be a potential candidate for the prevention and/or treatment of some diseases due to its anti-oxidant, antiinflammatory activities and an excellent safety profile. We present an updated concise review of currently available animal and clinical studies demonstrating the therapeutic effect of curcumin.

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Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced chromosomal aberrations in CHO cells

Cited by 12 publications

References 19 publications

A comparative evaluation of the efficacy of curcumin and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A double-blinded randomized controlled clinical study

A comparative evaluation of the efficacy of curcumin and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A double-blinded randomized controlled clinical study

Curcumin: From ancient medicine to current clinical trials

A Review of Therapeutic Effects of Curcumin

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