Curcumin: From ancient medicine to current clinical trials

Hatcher, Heather; Planalp, Roy P.; Cho, J.; Torti, Frank M.; Torti, Suzy V.

doi:10.1007/s00018-008-7452-4

Cited by 1,631 publications

(1,238 citation statements)

References 200 publications

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“…Research has revealed that curcumin has a surprisingly wide range of beneficial properties, including antiinflammatory, antioxidant, chemopreventive and chemotherapeutic activity. These activities have been demonstrated both in cultured cells and in animal models, and have paved the way for ongoing human clinical trials (Hatcher et al, 2008). Previous report showed that curcumin inhibits the production of proinflammatory monocyte/macrophage-derived cytokines in PMA-or LPS-stimulated peripheral blood monocytes and alveolar macrophages (Abe et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…It can suppress TNF expression induced by numerous stimuli and in numerous cell types. Recent work has suggested that curcumin acts as a cancer chemopreventive and chemotherapeutic agent (Chuang et al, 2000;Goel et al, 2008;Hatcher et al, 2008;Jiao et al, 2009). Curcumin inhibits activation of nuclear factor κB through blockade of IκB kinase, and inhibits activation of cyclooxygenase 2 (COX2).…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic use of fisetin, curcumin, and mesoporous carbon nanoparticle loaded fisetin in bleomycin-induced idiopathic pulmonary fibrosis

Kar¹,

Konsam²,

Hore³

et al. 2015

Biomed Res Ther

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Abstract-Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown etiology, for which there is no curative pharmacological therapy. Bleomycin, an anti-neoplastic agent that causes lung fibrosis in human patients has been used extensively in rodent models to mimic IPF. The conventional therapy has been steroids and immunosuppressive agents. But only a minority of patients responds to such a therapy. IPF is a progressive, ultimately fatal disorder for which substantive medical therapy is desperately needed. Fisetin is a flavonol which inhibits the activity of several pro-inflammatory cytokines. The polyphenol curcumin is used to treat inflammatory diseases, abdominal disorders, and a variety of other ailments. The aim of this study was to evaluate the beneficial effect of fistine, curcumin and mesoporous carbaon nanoparticle (MCN) loaded fisetin as an anti-inflammatory agents against bleomycin-induced changes in mice with IPF. In our study, flavonoids showed their anti fibrotic action. The inflammatory cell count was greatly increased for bleo treated individuals and effectiveness of fisein was increased after addition of MCN particles with it, curcumin also showed anti-inflammatory effects. In another experiment, bleomycin effectively inhibits the cellular recruitment to the spleen and treatment with fisetin, and curcumin increases the cellular recruitment in spleen. Colony count was also increased in MCN+fisetin treated groups, and it was statistically significant. We also observed the increased level of cytokines with fisetin treatment, with curcumin treatment and with MCN +fisetin treatment as compared to the bleo treated sample. In conclusion, the present research suggests that fisetin and curcumin and MCN loaded fisetin may be a promising therapeutic agent for bleomycin-induced changes in mice with IPF. This will open up new perspectives for a potential role of these drugs as a molecular target in Idiopathic pulmonary fibrosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic use of fisetin, curcumin, and mesoporous carbon nanoparticle loaded fisetin in bleomycin-induced idiopathic pulmonary fibrosis

Kar¹,

Konsam²,

Hore³

et al. 2015

Biomed Res Ther

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“…Curcumin has been shown to act as a cancer chemopreventive and chemotherapeutic agent (Chuang, 2000;Goel et al, 2008;Hatcher et al, 2008;Jiao et al, 2008). Curcumin, a polyphenolic compound, has been successfully used for treatment of various diseases such as allergies, arthritis, diabetes, Alzheimer's disease and other chronic diseases Manolova et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Evaluating the ameliorative potential of plant flavonoids and their nanocomposites in bleomycin induced idiopathic pulmonary fibrosis

Kar¹,

Biswas²,

Banerjee³

2016

Biomed Res Ther

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Abstract-Introduction: Pulmonary Fibrosis can severely disrupt lung function. The cause of Idiopathic Pulmonary Fibrosis (IPF) is still unclear. The treatment currently available for IPF provides minimal benefits. Bleomycin is used in research to induce experimental pulmonary fibrosis in animals. Plant flavonoids such as fisetin and curcumin are known for their anti-inflammatory properties. The aim was to demonstrate the path of physiological changes in bleomycin induced IPF and to further evaluate the reversal and ameliorative potentials of some plant flavonoids and their nanocomposites. Bleomycin administration is known to damage the lung epithelial cells resulting in lower cell numbers. Methods: The Balb/c mice were used as models for bleo-induced IPF. Inflammation was measured by the generation of ROS, RONI, and histological assessment. Cell proliferation was measured by MTS assay and CFU assay. Results: Our colony-forming assay in BALF also demonstrated a reduction (1.65 fold) in colony-forming unit after bleomycin administration. The number of colonies increased upon treatment with fisetin(1.20 fold) and curcumin (1.13 fold) respectively. MTT proliferation assay demonstrated a significant increase in the number of viable cells upon treatment with curcumin (1.42 fold) and fisetin (1.74 fold) respectively, in the lung. The NBT assay demonstrated a significant effect of curcumin in BALF, lung and peripheral blood. A significant effect of fisetin was observed in BALF and peripheral blood. Conclusion: These findings were also supported by the histological analyses of the lung samples. Curcumin showed highest potential for the treatment of IPF and fisetin showed its ameliorative effect.

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“…It has asurprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemo-therapeutic activity and has been used to treat several different cancers [3][4][5]. However, although curcumin is non-toxic and has promising anti-cancer activities, preclinical and clinical studies indicate that its poor bioavailability and weak pharmacokinetic profiles derived from its structural instability under physiological conditions have seriously limited its application in anti-cancer therapies [6,7].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of (2E,6E)-2,6-bis(2,4-dimethoxybenzylidene)- cyclohexanone, C24H26O5

Yu-Hong¹,

Jiang²,

Guang-Ye³

et al. 2010

Zeitschrift Für Kristallographie - New Crystal Structures

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Source of materialThe title compound was prepared using the method as previously described [1]. An amount of 7.5 mmol cyclohexanone was added to asolution of 15 mmol 2,4-dimethoxybenzaldehyde in MeOH (10 ml). The solution was stirred at room temperature for 20 min, followed by dropwise addition of NaOMe/MeOH (1.5 ml, 7.5 mmol). The mixture was stirred at room temperature and monitored with TLC. When the reaction was finished, the residue was poured into saturated NH 4 Cl solution and filtered. The precipitate was washed with water and cold ethanol, and dried in vacuum. Single crystals were obtained by re-crystalliza-tion from amethanol/chloroform solution (1:2, v/v)at293 K. Experimental detailsThe hydrogen atoms bound to carbon atoms were positioned geometrically and allowed to ride on their parent atoms with d(Csp 2 -H) =0.93 Å and U iso =1.2 U eq (C), and d(Csp 3 -H) = 0.97 Å and U iso =1 .5 U eq (C). The relatively high temperature (293 K) in detection system may result in large displacement parameters. DiscussionCurcumin, awell-known food additive, has long been used in traditional medicine to treat various inflammatory diseases in China and India [2]. It has asurprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemo-therapeutic activity and has been used to treat several different cancers [3][4][5]. However, although curcumin is non-toxic and has promising anti-cancer activities, preclinical and clinical studies indicate that its poor bioavailability and weak pharmacokinetic profiles derived from its structural instability under physiological conditions have seriously limited its application in anti-cancer therapies [6,7]. In the past two decades, alot of efforts has been put into the chemical modification of curcumin to identify potential analogues with better bioavailability and antitumor activities [5,[8][9][10]. The title compound, one of monocarbonyl curcumin analogues has demonstrated excellent cytotoxic properties against several human cancer cell lines in vitro (data not shown). The activity against tumor growth and stable structure renders it apotential candidate for therapeutic applications for cancers. The molecule C 24 H 26 O 5 contains two benzene rings. Their geometrical parameters are in normal range. The bond lengths within phenyl rings are between 1.367(3) Å and 1.397(3) Å,which highlights the aromatic character. The dihedral angle between the aromatic ring planes is 3.5(7)°.T he long and flat shape of the molecules favors their packing in the crystal structure. There are no hydrogen bonds and strong interactions between the molecules.

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Curcumin: From ancient medicine to current clinical trials

Cited by 1,631 publications

References 200 publications

Therapeutic use of fisetin, curcumin, and mesoporous carbon nanoparticle loaded fisetin in bleomycin-induced idiopathic pulmonary fibrosis

Therapeutic use of fisetin, curcumin, and mesoporous carbon nanoparticle loaded fisetin in bleomycin-induced idiopathic pulmonary fibrosis

Evaluating the ameliorative potential of plant flavonoids and their nanocomposites in bleomycin induced idiopathic pulmonary fibrosis

Crystal structure of (2E,6E)-2,6-bis(2,4-dimethoxybenzylidene)- cyclohexanone, C24H26O5

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