Distribution of the CCR2-64I allele in three Brazilian ethnic groups

Abstract

CCR2 is a member of the superfamily of seven transmembrane domain G protein-coupled receptors, the largest receptor superfamily in the human genome. CCR2 acts as a receptor for MCP-1 (CC chemokine) and as a co-receptor for HIV-1 cell-target entry. The gene encoding this receptor is mapped to the chromosome band 3p21. A G-to-A transition at position 190 characterizes the CCR2-64I mutation, causing valine to isoleucine substitution in codon 64. This mutation has been identified as an important factor for delaying progression to AIDS. Here, we determined the prevalence of this allele in three different Brazilian populations: 261 Amerindians inhabiting an isolated region in northern Brazil (82 samples from the Waiampi tribe, and 179 samples from the Tiriyó tribe); 89 German descendents from Joinville, a city in southern Brazil; and 305 individuals of predominantly African ancestry, from Salvador, a city in northeast Brazil. The CCR2-64I mutant allele was identified in 26% of the Tiryió and 30% of Waiampi samples, in 18% of the Joinville samples, and in 14% of the Salvador samples.

Prevalence of CCR5-Δ32 and CCR2-V64I polymorphisms in a mixed population from northeastern Brazil

“…Furthermore, in a Taiwanese population, a frequency of 14.4% for allele-64I was reported, which is consistent with the population observed in this study (P > 0.05) (Lin et al, 2012). Our results were also consistent with those observed in African and some American populations, although the frequency of allele-64I in these populations is relatively higher, as observed in Cameroon (19.9%), Colombia (23.2%), and Mexico (24.2%) (P > 0.05) Vázquez-Lavista et al, 2009;Zapata et al, 2013 Within the Brazilian territory, the frequency of the CCR2-V64I polymorphism observed in the Piauí population was similar to that reported for the general population in other states as well as in European subpopulations or in individuals of African descent (Acosta et al, 2003;De Pinho Lott Carvalhaes et al, 2004;Vargas et al, 2005;Zambra et al, 2013). Notably, the observed frequency in indigenous tribes in northern Brazil may be as high as 30%, a significantly higher frequency than that observed in this study (P < 0.05) (Acosta et al, 2003).…”

“…The population of this state comprised 60% European, 21.5% African, and 18.5% indigenous peoples. The distribution of CCR5-D32 and CCR2-64I polymorphisms has been studied in different regions in Brazil (Acosta et al, 2003;De Pinho Lott Carvalhaes et al, 2004;Boldt et al, 2009); however, the frequencies of these polymorphisms in Piauí have not been reported. Therefore, in this study, we analyzed the prevalence of the CCR5-D32 and CCR2-V64I polymorphisms in a sample population in the State of Piauí and compared their frequencies to those observed in Brazil and other countries.…”

The effect of combined polymorphisms in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population

“…It has been found in high frequencies in Oceania and in lower frequencies in Africa (Su et al 2000). In Brazil, Grimaldi et al (2010), studying the same three populations that were analysed by Acosta et al (2003) for CCR2-64I, found an allelic frequency of 21% in the population of the South, similar to the frequency found in this study (20.1%). In the Northeast, the frequency was found to be 17% and, in the North, frequencies of 24% and 5% were observed in two different Amerindian tribes.…”

“…Acosta et al (2003) investigated the CCR2-64I mutation in three different Brazilian populations and found it at a frequency of 26% in Amerindians in the North, 30% among German descendants in the South and 14% in African descendants in the Northeast. In this study, we found the CCR2-64I allele to have a frequency of 11.3%.…”

Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia

“…: European, 13%; African, 17%, Asian 13% (Su et al, 1999(Su et al, , 2000Martinson et al, 2000. A previous study performed on a sample of the general population of the northern Brazilian city of Belém, the capital of the state of Pará, population around 1,4 million (Brazilian Institute of Geography and Statistics -IBGE, 2004) in the Brazilian Amazon revealed the presence of the CCR2-64I mutation at a frequency of 0.161 (Carvalhaes et al, 2004) but higher frequencies have been found in Afro-Brazilians (0.230), whereas in Brazilian Amerindians the frequency of this mutation varies from 0.030 to 0.300 (Su et al, 1999;Acosta et al, 2003;Carvalhaes et al, 2004).…”