Centromeric, pericentromeric and heterochromatin abnormalities in chromosomal rearrangements of human leukemia

Berger, Roland

doi:10.1590/s1415-47572000000400060

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(2 citation statements)

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“…Besides these common cytogenetic abnormalities, there are some rare variants of translocations such as dicentric chromosomes [2]. In human leukemia, recurrent and clonal dicentric chromosomes have been found to be associated with some subtypes of leukemia, such as dic(5;17) and dic(17;18) in myeloid cell proliferations, and dic(7;9), dic(9;12) and dic(9;20) in acute lymphoblastic leukemias [6]. We report a case of acute myeloblastic leukemia with a dic(1;15)(p11;p11), resulting in trisomy of the long arm of chromosome 1.…”

Section: Discussionmentioning

confidence: 99%

“…However, the translocation breakpoints are likely to be in heterochromatic regions. Heterochromatin could have roles in centromere architecture and the prevention of merotely, but the possible consequences of heterochromatin rearrangements are still a question mark [6]. Heterochromatin rearrangements (partial trisomies and monosomies) cause imbalance by silencing genes placed in the region of chromosomal breakpoints due to the translocation of heterochromatin to ectopic location [14].…”

Section: Discussionmentioning

confidence: 99%

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A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature

Şahin

Durak

Gündüz

et al. 2013

Case Reports in Genetics

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Acute myelogenous leukemia (AML) develops as the consequence of a series of genetic changes in a hematopoietic precursor cell. Specific cytogenetic abnormalities have been identified by karyotype analysis in AML. One of the rare chromosomal abnormalities is a dicentric chromosome, which is defined as an aberrant chromosome having two centromeres. In the literature, a limited number of cases have been reported with dic(1;15) in myeloid disorders, but only one case has been reported with in acute megakaryoblastic leukemia. Herein, we report a case of acute myelogenous leukemia without maturation with a dic(1;15)(p11;p11), resulting in trisomy of the long arm of chromosome 1. To date, this is the second case of dic(1;15) in acute myelogenous leukemia and the first case in acute myeloblastic leukemia without maturation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%