A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature

Şahin, Deniz; Durak, Beyhan; Gündüz, Eren; Artan, Sevilhan; Akay, Olga Meltem

doi:10.1155/2013/462896

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…• In MDS, the typical abnormalities are partial and complete chromosome loss, most commonly −5, 5q-, −7, 7q-, +8, 11q-, 13q-, 20q-, and -Y [6,14,15].…”

Section: Indications Of the Chromosome Analysis In Prenatal Postnatamentioning

confidence: 99%

The Use of Molecular Cytogenetic Techniques for the Identification of Chromosomal Abnormalities

Kalkan¹

2017

Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability

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Chromosomal analysis is an increasingly important diagnostic procedure in numerous areas of clinical medicine that includes haematology, perinatology or obstetrics. Chromosomal disorders are viewed as a major category of genetic diseases, and sometimes the identiication of abnormal chromosomes is not easily applicable. Just like the identiication of the marker chromosome or the identiication of the complex karyotypes is important in clinics for the evaluation of the patient prognosis as well as the treatment response, needless to say; luorescence in situ hybridization (FISH) is the most suitable and rapid method in the above-mentioned situations. It gives chance to the rapid analysis of chromosomal aneuploidies in dividing and non-dividing cells. In this chapter, we will discuss the general principles of the chromosomal abnormalities and the molecular cytogenetic techniques that can help the identiication of presence or absence of a particular DNA sequence or the evaluation of the number of organization of a chromosome or chromosomal region.

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“…• In MDS, the typical abnormalities are partial and complete chromosome loss, most commonly −5, 5q-, −7, 7q-, +8, 11q-, 13q-, 20q-, and -Y [6,14,15].…”

Section: Indications Of the Chromosome Analysis In Prenatal Postnatamentioning

confidence: 99%

The Use of Molecular Cytogenetic Techniques for the Identification of Chromosomal Abnormalities

Kalkan¹

2017

Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability

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“…However, chromosomal translocations of breakpoints in this disorder occur in heterochromatin. 36 Heterochromatin rearrangements (relative trisomies and monosomies) cause imbalance by gene silencing in chromosomal breakpoints, leading to displacement of heterochromatin to an ectopic location. They also provoke functional changes in genes and chromatin coupled proteins.…”

Section: Rare Cytogenetic Abnormalities In Acute Myeloid Leukemia Witmentioning

confidence: 99%

“…In general, this disorder has a poor prognosis and response to treatment with induction chemotherapies. 36 , 37…”

Section: Rare Cytogenetic Abnormalities In Acute Myeloid Leukemia Witmentioning

confidence: 99%

Rare cytogenetic abnormalities and alteration of microRNAs in acute myeloid leukemia and response to therapy

Shahjahani

Seghatoleslami

et al. 2015

Oncol Rev

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Acute myeloid leukemia (AML) is the most common acute leukemia in adults, which is heterogeneous in terms of morphological, cytogenetic and clinical features. Cytogenetic abnormalities, including karyotype aberrations, gene mutations and gene expression abnormalities are the most important diagnostic tools in diagnosis, classification and prognosis in acute myeloid leukemias. Based on World Health Organization (WHO) classification, acute myeloid leukemias can be divided to four groups. Due to the heterogeneous nature of AML and since most therapeutic protocols in AML are based on genetic alterations, gathering further information in the field of rare disorders as well as common cytogenetic abnormalities would be helpful in determining the prognosis and treatment in this group of diseases. Recently, the role of microRNAs (miRNAs) in both normal hematopoiesis and myeloid leukemic cell differentiation in myeloid lineage has been specified. miRNAs can be used instead of genes for AML diagnosis and classification in the future, and can also play a decisive role in the evaluation of relapse as well as response to treatment in the patients. Therefore, their use in clinical trials can affect treatment protocols and play a role in therapeutic strategies for these patients. In this review, we have examined rare cytogenetic abnormalities in different groups of acute myeloid leukemias according to WHO classification, and the role of miRNA expression in classification, diagnosis and response to treatment of these disorders has also been dealt with.

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A case of dic (1:15) (p11;p11) with t(9:22)(q34:q11) in B-ALL

2015

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A New Case of dic(1;15)(p11;p11) in AML M1: Apropos of a Case and a Review of the Literature

Cited by 3 publications

References 12 publications

The Use of Molecular Cytogenetic Techniques for the Identification of Chromosomal Abnormalities

The Use of Molecular Cytogenetic Techniques for the Identification of Chromosomal Abnormalities

Rare cytogenetic abnormalities and alteration of microRNAs in acute myeloid leukemia and response to therapy

A case of dic (1:15) (p11;p11) with t(9:22)(q34:q11) in B-ALL

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