Beta-globin gene cluster haplotypes in the Mapuche Indians of Argentina

Kaufman, Leticia; Carnese, Francisco R.; Goicoechea, Alicia Susana; Dejean, Cristina Beatriz; Salzano, Francisco M.; Hutz, Mara Helena

doi:10.1590/s1415-47571998000400003

Cited by 16 publications

(8 citation statements)

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“…The distribution of haplotypes associated with the βA gene is now known for a large number of populations. The data indicate that Africans are the most divergent group, and that the first split separated an African group from an Eurasian one Oehme et al, 1985;Antonarakis et al, 1985;Maggio et al, 1986;Kulozik et al, 1986;Ramsay and Jenkins, 1987;Hundrieser et al, 1988a,b;Yongvanit et al, 1989;Chen et al, 1990;Long et al, 1990;Trent et al, 1990;Shimizu, 1987;Shimizu et al, 1989;Varawalla et al, 1992;Penaloza et al, 1995;Hewitt et al, 1996;Castro-de-Guerra et al, 1997;Fucharoen et al, 1997;Kaufman et al, 1998;Villalobos-Arámbula et al, 2000). The distribution of βA haplotypes in Brazilian Amerindian populations was investigated in ten tribes of the Amazon region by Guerreiro et al (1992Guerreiro et al ( , 1994 and Bevilacqua et al (1995), who obtained similar results.…”

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confidence: 99%

Genetic relationships among native americans based on beta-globin gene cluster haplotype frequencies

et al. 2003

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The distribution of β-globin gene haplotypes was studied in 209 Amerindians from eight tribes of the Brazilian Amazon: Asurini from Xingú, Awá-Guajá, Parakanã, Urubú-Kaapór, Zoé, Kayapó (Xikrin from the Bacajá village), Katuena, and Tiriyó. Nine different haplotypes were found, two of which (n. 11 and 13) had not been previously identified in Brazilian indigenous populations. Haplotype 2 (+ ----) was the most common in all groups studied, with frequencies varying from 70% to 100%, followed by haplotype 6 (-+ + -+), with frequencies between 7% and 18%. The frequency distribution of the β-globin gene haplotypes in the eighteen Brazilian Amerindian populations studied to date is characterized by a reduced number of haplotypes (average of 3.5) and low levels of heterozygosity and intrapopulational differentiation, with a single clearly predominant haplotype in most tribes (haplotype 2). The Parakanã, Urubú-Kaapór, Tiriyó and Xavante tribes constitute exceptions, presenting at least four haplotypes with relatively high frequencies. The closest genetic relationships were observed between the Brazilian and the Colombian Amerindians (Wayuu, Kamsa and Inga), and, to a lesser extent, with the Huichol of Mexico. North-American Amerindians are more differentiated and clearly separated from all other tribes, except the Xavante, from Brazil, and the Mapuche, from Argentina. A restricted pool of ancestral haplotypes may explain the low diversity observed among most present-day Brazilian and Colombian Amerindian groups, while interethnic admixture could be the most important factor to explain the high number of haplotypes and high levels of diversity observed in some South-American and most North-American tribes.

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Section: Introductionmentioning

confidence: 99%

Genetic relationships among native americans based on beta-globin gene cluster haplotype frequencies

et al. 2003

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“…Eleven South American Indian tribes have already been screened for this nuclear region (Guerreiro et al, 1994;Bevilaqua et al, 1995;Kaufman et al, 1998). Eleven haplotypes were identified among these popula-tions, but only two of them, numbers 2 (ϩϪ Ϫ Ϫ Ϫ) and 6 (Ϫϩϩ Ϫϩ), were shared by all groups.…”

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confidence: 99%

Beta-globin gene cluster haplotypes in two North American indigenous populations

Mattevi

Fiegenbaum

Salzano

et al. 2000

Am. J. Phys. Anthropol.

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Haplotypes derived from five polymorphic restriction sites were determined in 50 Carrier-Sekani and 70 Mvskoke chromosomes, and the results were integrated with those previously obtained for 11 South American Indian populations. Eleven haplotypes were identified in the Mvskokes, while five were observed in the Carrier-Sekani. As in South American natives, haplotype 2 (+----) and 6 (-++ -+) were the most prevalent among the Mvskoke (46% and 30%, respectively). In the Carrier-Sekani, haplotype 2 was also the most common, but haplotype 5 (-+ -++) was somewhat more frequent (18%) than 6 (12%). High heterozygosities, as well as genetic differentiation, were observed among these two North American and two other South American groups (Mapuche and Xavante). They could be due to non-Indian admixture in the Mvskoke and Mapuche, but the findings in the other two populations require some other type of explanation.

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“…All Japanese and Koreans who possessed subhaplotype 1 were heterozygous for subhaplotypes 1 and 2. This subhaplotype 1 (-----) has been reported already in Argentine Amerinds (Kaufman et al, 1998), Mexican mestizos (Villalobos-Arambula et al, 1986), Lowland (Chen et al, 1990) and Highland Melanesians (Hill et al, 1988), Polynesians (Wainscoat et al, 1986), Algerians (Rouabhi et al, 1988), and Asian Indians (Varawalla et al, 1992). It has also recently been described in Inga Amerind of Colombia (Mesa et al, 2000).…”

Section: Resultsmentioning

confidence: 55%

Re-evaluation of the .BETA.-globin gene cluster haplotypes in Japanese, Koreans, and three Colombian Amerinds (Wayuu, Kamsa, and Inga tribes)

Shimizu

Harihara

2004

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The EH program for maximum-likelihood (ML) frequencies based on an expectation-maximization (EM) algorithm was employed for re-estimation of the b-globin gene cluster haplotype frequency distributions in Japanese, Koreans, and three Colombian Amerinds (Wayuu, Kamsa, and Inga tribes). The distributions estimated by the EH program (estimation 3) were compared with those of our previous studies obtained from individuals who were homozygous at all polymorphic restriction sites or heterozygous at only one site (estimation 1), or ascertained by family linkage studies in Japanese and Koreans (estimation 2). Average haplotype diversities and Nei's genetic distances based on estimation 3 were also compared with those based on estimations 1 and 2. Haplotypes of all chromosomes examined, which were based on RFLPs (restriction fragment length polymorphisms) at five or seven sites in the b-globin gene cluster, were determined by the EH program as in the case of a family linkage study. The average haplotype diversities based on estimation 3 were much higher than those based on estimations 1 and 2. The present study based on estimation 3 confirmed the close genetic relationships between Japanese and Koreans, and also between Wayuu and Kamsa. Colombian Amerinds showed some African or European characteristics as well as those of Asians.

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Beta-globin gene cluster haplotypes in the Mapuche Indians of Argentina

Cited by 16 publications

References 10 publications

Genetic relationships among native americans based on beta-globin gene cluster haplotype frequencies

Genetic relationships among native americans based on beta-globin gene cluster haplotype frequencies

Beta-globin gene cluster haplotypes in two North American indigenous populations

Re-evaluation of the .BETA.-globin gene cluster haplotypes in Japanese, Koreans, and three Colombian Amerinds (Wayuu, Kamsa, and Inga tribes)

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