Quadro clínico do envenenamento crotálico experimental em bovinos (Crotalus durissus terrificus - crotamina positivo)

Lago, Luiz Alberto do; Ferreira, Paulo Marcos; Filho, Elias Jorge Facury; Melo, Marília Martins; Filho, Fernando Alzamora

doi:10.1590/s1413-95962000000400010

Cited by 9 publications

(24 citation statements)

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“…The results from this study are in accordance with the findings from other authors that report the same clinical signs in bovine two to six hours after venom inoculation (Belluomini et al 1982, Lago et al 2000, and in dogs two, four and six hours after venom inoculation (Collicchio et al 2002, Nogueira & Sakate 2006. Our study did not show a significant difference between groups VS and VSM, thus differing from the results obtained by Maiorano et al (2005), in which the venom's neurotoxic action was completely inhibited by extracts from fresh or dried roots and stems of M. glomerata.…”

Section: Discussionsupporting

confidence: 93%

“…This study showed an increase in CK values for groups VS and VSM at M1 and M2, consistent with the authors that mention that crotalic venom has effects on muscle fibers (Azevedo-Marques et al 1985, Lago et al 2000.…”

Section: Discussionsupporting

confidence: 93%

“…Temperature decrease occurred due to the state of shock and release of vasoactive agents at anaphylaxis, which is consistent with other reports, including hypothermia between six and 24 hours after venom inoculation (Lago et al 2000, Raiser 2002, Nogueira & Sakate 2006. Dyspnea and lower respiratory and cardiac frequencies were seen, especially in animals from group VS, which are related to the crotalic venom's myotoxic and neurotoxic action.…”

Section: Discussionsupporting

confidence: 90%

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Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats

Floriano

Nogueira

Sakate³

et al. 2009

RBT

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Abstract:Crotalic envenomation represents the highest number of deaths when compared to other snakebite envenomations of medical interest. Crotalic venom has important characteristics such as neurotoxicity, myotoxicity, nephrotoxicity, and clotting and hemolytic action. We evaluated the clinical and laboratory aspects of Crotalus durissus terrificus experimental envenomation in Wistar rats treated with antivenom and the aqueous extract of the plant Mikania glomerata. The animals were divided into three groups: Group C (control); Group VS-venom and antivenom; Group VSM-venom, antivenom and aqueous extract of M. glomerata. Crotalic poison caused clinical and laboratory alterations in Wistar mice. Significant clinical alterations were: temperature decrease, edema in the venom inoculated member, sedation and a locomotion decrease in groups VS and VSM when compared with group C. A faster recovery from sedation was observed only for animals of group VSM when compared to VS. There was an increase in the number of leukocytes, neutrophils and creatine kinase in the VS and VSM groups, compared to group C. Wistar rats showed a high resistance to crotalic venom. Additional studies with different doses, time of treatment, different administration methods and histopathological and immunological studies are necessary to understand the action of M. glomerata in crotalic accidents. Rev. Biol. Trop. 57 (4): 929-937. Epub 2009 December 01.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

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Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats

Floriano

Nogueira

Sakate³

et al. 2009

RBT

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“…According to some authors, non-steroidal anti-inflammatory drugs (NSAID) and cyclooxygenase inhibitors (such as flunixin meglumine, employed in the present case) are indicated for the treatment of accidents involving Bothrops snakes in cattle (11,26,27).…”

Section: Discussionmentioning

confidence: 99%

Triple bothropic envenomation in horses caused by a single snake

Chiacchio

Martins

Amorim³

et al. 2011

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:In the present study, snakebites caused by a single Bothrops pauloensis simultaneously affecting three male adult horses are described. Whereas the first two affected horses were six years old, the third was 16 years old; they weighed respectively 555, 550 and 500 kg. All horses presented swollen muzzles. The first animal received an initial antivenom dose of 19 vials and adjuvant medication, it was also subjected to tracheostomy due to the progression of acute respiratory failure. The second and third horses respectively received 15 vials of antivenom each, in addition to adjuvant medication. Due to continuous changes in blood coagulation observed during hospitalization, the first and the second horses received five more vials of antivenom, respectively, in the second and third days of treatment. The first animal was discharged on 15 th day and the other on the 8 th day of hospitalization. Several factors including the main actions of Bothrops venom (coagulation, proteolytic and vasculotoxic activities), the importance of early diagnosis based on clinical history and clinical examination suggesting the diagnosis of Bothrops snakebite, the adequate doses of antivenom, and finally the immediate tracheostomy are herein discussed. The tracheostomy, required to save the life of the first horse, should only occur after the administration of antivenom and control measures for changes in blood coagulation.

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“…Lago et al (2000) realizaram experimento com a dose de 0,03mg/kg do veneno crotálico do tipo crotamina em cinco bovinos fêmeas, a ϐim de descrever o quadro clínico do envenenamento cr otálico nessa espécie. Utilizaram a via intramuscular para inoculação e observaram que, decorridas 20 horas a partir desse procedimento, os animais apresentaram queda progressiva da temperatura retal e morreram.…”

Section: Discussionunclassified

Aspectos clínico-patológicos e laboratoriais do envenenamento crotálico experimental em equinos

et al. 2012

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Pesq. Vet. Bras. 32(9):843-849, setembro 2012 843 RESUMO.-Descrevem-se os quadros clínico-patológicos e laboratoriais de equinos inoculados experimentalmente com a peçonha de Caudisona durissa terriϔicus (Crotalus durissus terriϔicus na antiga nomenclatura), com a ϐinalidade de fornecer subsídios que favoreçam a compreensão desse tipo de acidente oϐídico em equinos. O veneno lioϐilizado foi diluído em 1ml de solução salina a 0,9% e inoculado por via subcutânea em cinco equinos, nas doses de 0,12mg/kg (um animal), 0,066mg/kg (dois animais) e 0,03mg/kg (dois animais The clinic-pathological picture and laboratory ϐindings in horses experimentally inoculated with the venom of Caudisona durissa terriϔicus (Crotalus durissus terriϔicus, according to the former nomenclature) are described. The purpose of this study was to contribute to the understanding of this type of snake accident in horses. The lyophilized venom was diluted into 1ml of a 0.9% saline solution and was inoculated subcutaneously into ϐive horses, at the doses of 0.12mg/kg (one horse), 0.066mg/kg (two horses) and 0.03mg/kg (two horses). The venom caused death of the horse that had received 0.12mg/kg, and of one horse of the two that had received the dose of 0.066mg/kg. The clinical course varied from 27h27min to 52h29min. The second horse inoculated with 0.066mg/kg recovered within 12 days after inoculation. The dose of 0.03mg/kg had a course of 6 to 10 days, but did not cause fatal envenomation. The clinical picture in the horses was characterized by swelling of the inoculation site (shoulder) that spread to the whole leg, by apathy and lowered head, locomotory alterations shown by dragging of the hoves on the ground, decubitus and difϐi-culty to get up, reduction of auricular, palatal, upperlip and threat reϐlexes, and increase of heart and breathing frequency. The laboratory examination revealed leukocytosis and lymphocytosis in two horses. There was increase of the creatine-kinase (CK), lactic dehydrogenase (DHL) and urea, and reduction in the seric levels of calcium, phosphorus and magnesium. The activated partial tromboplastina time (TTPA) increased in the horses that died. Postmortem ϐindings were edema of the subcutaneous tissue of the whole leg into which the venom was inoculated, suffusions in the epicard of left and right heart ventricles, and bladder with hemorrhagic areas in its mucosa. Histopatologic examination revealed the liver parenchyma with diffuse moderate vacuolation affecting predominantly the intermediate area of the hepatic lobe, and slight dilation of the sinusoides in some areas, and slight dilation of the kidney tubules mainly in the cortex.

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Quadro clínico do envenenamento crotálico experimental em bovinos (Crotalus durissus terrificus - crotamina positivo)

Cited by 9 publications

References 0 publications

Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats

Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats

Triple bothropic envenomation in horses caused by a single snake

Aspectos clínico-patológicos e laboratoriais do envenenamento crotálico experimental em equinos

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