Mycobacterium aurum keratitis: an unusual etiology of a sight-threatening infection

Honarvar, Behnam; Movahedan, Hossein; Mahmoodi, Masoud; Sheikholeslami, Fatemeh Maryam; Farnia, Parissa

doi:10.1590/s1413-86702012000200019

Cited by 2 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fast-growing nature of M. fortuitum enables rapid data generation, and drug screening data have been used as a barometer of potential activity in M. tuberculosis (Renau et al 1995 , 1996 , Gillespie et al 2001 , 2005 ). Mycobacterium aurum is an RGM typically considered a commensal, although rare cases of infection in immunocompromised individuals have been reported (Honarvar et al 2012 ). Mycobacterium aurum has also been used as a surrogate for M. tuberculosis for in vitro drug screening of antimycobacterial compounds (Gupta et al 2009 , Gupta and Bhakta 2012 ).…”

Section: Mycobacterium Marinum Mycobacterium Fortuitum and ...mentioning

confidence: 99%

Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs

Asai

Newton

et al. 2023

FEMS Microbiology Reviews

View full text Add to dashboard Cite

Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious disease models, due to ease of use and the presence of an innate immune system functionally similar to that of vertebrates. Here we review G. mellonella-human intracellular bacteria pathogen infection models from the genera Burkholderia, Coxiella, Francisella, Listeria, and Mycobacterium. For all genera, G. mellonella use has increased understanding of host-bacterial interactive biology, particularly through studies comparing the virulence of closely related species and/or wild-type versus mutant pairs. In many cases, virulence in G. mellonella mirrors that found in mammalian infection models, although it is unclear whether the pathogenic mechanisms are the same. The use of G. mellonella larvae has speeded up in vivo efficacy and toxicity testing of novel antimicrobials to treat infections caused by intracellular bacteria: an area that will expand since the FDA no longer requires animal testing for licensure. Further use of G. mellonella-intracellular bacteria infection models will be driven by advances in G. mellonella genetics, imaging, metabolomics, proteomics, and transcriptomic methodologies, alongside the development and accessibility of reagents to quantify immune markers, all of which will be underpinned by a fully annotated genome.

show abstract

Section: Mycobacterium Marinum Mycobacterium Fortuitum and ...mentioning

confidence: 99%

Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs

Asai

Newton

et al. 2023

FEMS Microbiology Reviews

View full text Add to dashboard Cite

show abstract

“…The species has been associated with infections in immunocompromised patients (Esteban et al., 1998; Koranyi and Ranalli, 2003; Martín‐Aspas et al., 2008) and with keratitis (Honarvar et al., 2012) in reports using bacterial identification methods currently recognised to be prone to misidentifications of Mycobacterium species (Tortoli, 2014). No food‐borne origin could be established.…”

Section: Assessmentmentioning

confidence: 99%

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 13: suitability of taxonomic units notified to EFSA until September 2020

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2021

EFS2

151

View full text Add to dashboard Cite

The qualified presumption of safety ( QPS ) approach was developed to provide a regularly updated generic pre‐evaluation of the safety of biological agents, intended for addition to food or feed, to support the work of EFSA 's Scientific Panels. It is based on an assessment of published data for each agent, with respect to its taxonomic identity, the body of knowledge, safety concerns and antimicrobial resistance. Safety concerns identified for a taxonomic unit ( TU ) are, where possible, confirmed at strain or product level, and reflected by ‘qualifications’. In the period covered by this statement, no new information was found that would change the status of previously recommended QPS TU s. Of the 36 microorganisms notified to EFSA between April and September 2020, 33 were excluded; seven filamentous fungi (including Aureobasidium pullulans based on recent taxonomic insights), one Clostridium butyricum , one Enterococcus faecium , three Escherichia coli , one Streptomyces spp. and 20 TU s that had been previously evaluated. Three TU s were evaluated; Methylorubrum extorquens and Mycobacterium aurum for the first time and Bacillus circulans was re‐assessed because an update was requested in relation to a new mandate. M. extorquens and M. aurum are not recommended for QPS status due to the lack of a body of knowledge in relation to use in the food or feed chain and M. aurum, due to uncertainty concerning its pathogenicity potential. B. circulans was recommended for QPS status with the qualifications for ‘production purposes only’ and ‘absence of cytotoxic activity’.

show abstract

Mycobacterium aurum keratitis: an unusual etiology of a sight-threatening infection

Cited by 2 publications

References 15 publications

Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs

Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 13: suitability of taxonomic units notified to EFSA until September 2020

Contact Info

Product

Resources

About