Expression of immunohistochemical markers in patients with AIDS-related lymphoma

Abstract

were high-grade lymphomas and 1% was follicular lymphoma. The positivity for each immunohistochemical marker in DLBCLs, Burkitt's lymphoma and plasmablastic lymphoma was respectively: CD20, 84%, 100%, and 0; CD10, 55%, 100%, and 0; Bcl-6, 45%, 80%, and 0; MUM-1, 41%, 20%, and 88%. A higher positivity of CD20 (84% x 56%, p = 0.01) was found in DLBCL compared to non-DLBCL; in Burkitt's lymphomas a higher positivity of CD10 (100% x 49%, p = 0.04) and Bcl-6 (80% x 39%, p = 0.035) were found compared to non-Burkitt's lymphomas. Germinal center (GC) profile was detected in 60% of DLBCLs.Our study suggests particular findings in ARL, as the most frequent phenotype was GC, different from HIV-negative patients.

Diffuse Large B-Cell Lymphoma in the Public-Sector of Johannesburg, South Africa, in the Era of Widescale Antiretroviral Therapy Use

“…On analysis of the COO (according to the Hans algorithm), the GC subtype predominated among PLWH (62.3%), whereas the non-GC subtype was more common in the HIV-negative group (60.9%). The COO pattern in the PLWH closely mirrors those of studies from China, 18 Malawi, 7 the USA, 24 Brazil 25 and Peru, 26 but differs from several other studies, which showed a variably large non-GC predominance. 11,14,19,21,27 This discrepancy between studies may be explained by poorer delineation of the COO using immunohistochemical techniques in the setting of HIV-DLBCL owing to differences in the tumor biology compared with that observed in immunocompetent individuals.…”

Biomarkers of HIV-associated Cancer

“…61 NHL is the second most common malignancy in HIV-infected patients, with diffuse large B-cell lymphoma (DLBCL) as the most common subtype of HIV-associated NHL (HIV-NHL) followed by Burkitt's lymphoma (BL). 62…”

“…61 NHL is the second most common malignancy in HIV-infected patients, with diffuse large B-cell lymphoma (DLBCL) as the most common subtype of HIV-associated NHL (HIV-NHL) followed by Burkitt's lymphoma (BL). 62 DLBCLs are heterogeneous diseases that differ in nature of the genetic abnormalities, morphologic appearance, clinical features, and patients respond differently to treatment and vary in prognosis. 63,64 Most DLBCLs are thought to arise from normal antigen exposed B-cells that have migrated to or through germinal centers.…”

Clinical and Molecular Properties of Human Immunodeficiency Virus-Related Diffuse Large B-Cell Lymphoma

“…However, its prognostic relevance was not yet addressed in the HIV-infected context, even though cMYC ( 179 ) and BCL2 ( 194 ) expression were described separately as prognostic factors for HIV-DLBCL. Similarly, another immunohistochemistry study detected high frequency (around 40%) of HIV-DLBCL samples positive for BCL6 and MUM1 ( 180 ).…”

“…Those investigations, however, resulted in conflicting data. Some reports consistently show enrichment of GCB phenotype in HIV-DLBCL samples ( 172 , 176 , 177 , 179 , 180 ). On the other hand, enhanced expression of ABC markers was also demonstrated for those cancers ( 186 , 187 , 195 ).…”