Unusual clinical presentations of brucellosis in childhood

Ulug, Mehmet; Yapici, Ferda; Can-Uluğ, Nuray

doi:10.1590/s1413-86702011000400022

Cited by 3 publications

(4 citation statements)

References 3 publications

(3 reference statements)

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“…Ülkemizde yapılan çalışmalarda en sık görülen yakınma ateştir ve bunu artralji izlemektedir (12)(13)(14)(20)(21)(22)(23)(24). Hindistan, Portekiz, Ürdün ve Suudi Arabistan'da yapılan çalışmalarda ise eklem yakınmalarının daha sık görüldüğü bildirilmiştir (25)(26)(27)(28).…”

Section: Discussionunclassified

Pediatric Brucellosis: A Retrospective Evaluation of 82 Cases

Abuhandan¹,

Güzel²,

Çakmak³

et al. 2012

J Pediatr Inf

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Amaç: Güneydoğu Anadolu bölgesi ülkemizde brusellozun endemik görüldüğü coğrafyada bulunmaktadır. Çalışmamızda bruselloz olgularının epidemiyolojik, klinik, laboratuvar bulguları ve tedavi yanıtlarını değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Ocak 2009-Eylül 2011 tarihleri arasında bruselloz tanısıyla izlediğimiz 82 olgu yaş, cinsiyet, geliş yakınmaları, bulaş yönünden riskleri, aile öyküsü, fizik muayene ve laboratuvar bulguları, uygulanan tedaviler açısından geriye dönük olarak değerlendirmeye alındı. Tanı yüksek brusella aglütinasyon titresi ve/veya kültürde etkenin üretilmesi ile konuldu. Bulgular: Olguların 37'si erkek 45'i kız olup, yaş ortalamaları 11.96±3.57 (yaş aralığı: 5-16) yıl idi. Olguların çoğunu (%76.8) kırsal kesimde yaşayan, tarım ve hayvancılıkla uğraşan ailelerin çocukları oluşturmaktaydı. En sık başvuru nedenleri ateş (%86.6), eklem ağrıları (%75.6), halsizlik (%51.2) ve terleme (%37.8) idi. Fizik muayenede; ateş (%90.2), artrit (%26.8), splenomegali (%22), hepatomegal (%20.7) ve lenfadenopati (%14.6) saptandı. Brusella aglütinasyon titresi tüm olgularda 1/160 ve üzerindeydi. Bir olgunun kan kültüründe, bir olguda beyin omurilik sıvısında üreme oldu. Sekiz yaş ve üzerinde olan 68 hastaya doksisiklin ve rifampisin, sekiz yaş altında olan 14 hastaya trimetoprim-sülfometaksazol (TMP/SMX) ve rifampisin kombinasyon tedavisi uygulanmıştı. Sonuç: Bruselloz çok değişik klinik belirtilerle karşımıza çıkabilmektedir. Hastalığın endemik olduğu bölgelerde özellikle ateş ve eklem ağrısı yakınması olan olgularda öncelikle düşünülmesi gereklidir.

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Section: Discussionunclassified

Pediatric Brucellosis: A Retrospective Evaluation of 82 Cases

Abuhandan¹,

Güzel²,

Çakmak³

et al. 2012

J Pediatr Inf

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“…Therefore, because of this dramatic response to the therapy, we concluded that the organism responsible for the arthritis and abscess of this patient was also probably Brucella melitensis . The prognosis of Brucella arthritis will be very good if appropriate and in time treatment is begun 12,19 . Unlike spondylitis, both sacroiliitis and peripheral arthritis are nondestructive and quickly curable with no sequelae 2,12 …”

Section: Discussionmentioning

confidence: 99%

“…The prognosis of Brucella arthritis will be very good if appropriate and in time treatment is begun. 12,19 Unlike spondylitis, both sacroiliitis and peripheral arthritis are nondestructive and quickly curable with no sequelae. 2,12 Thirty days after discharge at the follow-up visit, the patient did not relate a feeling of stiffness or heaviness in the left breast and occasional discharge from it which she had previously experienced, and also left sternoclavicular arthritis completely was cured.…”

Section: Discussionmentioning

confidence: 99%

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A 42‐year‐old female with sternoclavicular arthritis and breast abscess caused by brucellosis: A case report

Varshochi,

Ravanbakhsh Gavgani,

Ravanbakhsh Ghavghani

et al. 2023

Clinical Case Reports

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Key Clinical MessageThe main target of this report was that brucellosis can occur in unexpected and very rare patterns. We reported this patient to acknowledge all of clinicians especially those living in the endemic areas, that these rare complications of brucellosis can also be treated by the standard treatment of this disease.AbstractBrucellosis is a thousand‐face disease and common zoonotic infection in endemic regions. A 42‐year‐old female was admitted with sternoclavicular arthritis and breast abscess. After laboratory investigation and imaging, positive serological test results and positive blood culture for Brucella revealed acute sternoclavicular arthritis and breast abscess due to brucellosis.

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Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature

Makis

Perogiannaki

Chaliasos

2017

Case Reports in Infectious Diseases

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Brucellosis is still endemic and a significant public health problem in many Mediterranean countries, including Greece. It is a multisystemic disease with a broad spectrum of clinical manifestations including hematological disorders, such as anemia, pancytopenia, leucopenia, and thrombocytopenia. Thrombocytopenia is usually moderate and attributed to bone marrow suppression or hypersplenism. Rarely, autoimmune stimulation can cause severe thrombocytopenia with clinically significant hemorrhagic manifestations. We present the case of a girl with severe thrombocytopenic purpura as one of the presenting symptoms of Brucella melitensis infection. Treatment with intravenous immunoglobulin and the appropriate antimicrobial agents promptly resolved the thrombocyte counts. A review of similar published cases is also presented.

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Unusual clinical presentations of brucellosis in childhood

Cited by 3 publications

References 3 publications

Pediatric Brucellosis: A Retrospective Evaluation of 82 Cases

Pediatric Brucellosis: A Retrospective Evaluation of 82 Cases

A 42‐year‐old female with sternoclavicular arthritis and breast abscess caused by brucellosis: A case report

Severe Thrombocytopenic Purpura in a Child with Brucellosis: Case Presentation and Review of the Literature

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