Microbiological epidemiological history of meningococcal disease in Rio de Janeiro, Brazil

Barroso, David E.; Carvalho, DM; Casagrande, ST; Rebelo, MC; Soares, V; Zahner, V; Solari, CA; Nogueira, SA

doi:10.1590/s1413-86702010000300008

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…During 1993–1994, a total of 4 C:4 N. meningitidis isolates were identified in samples from patients in Rio de Janeiro State (RJ). The presence of class3-PorB in these strains suggested the possibility of B→C capsular switching ( 7 ). Since 2000, the number of cases of serogroup C disease has steadily increased in RJ ( 8 ), reaching 90% of laboratory-confirmed cases in 2009.…”

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confidence: 99%

Capsular Switching in InvasiveNeisseria meningitidis, Brazil1

Castiñeiras¹,

Barroso²,

Marsh³

et al. 2012

Emerg. Infect. Dis.

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Capsular Switching in InvasiveNeisseria meningitidis, Brazil1

Castiñeiras¹,

Barroso²,

Marsh³

et al. 2012

Emerg. Infect. Dis.

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“…Previous regional reports have described a predominant Brazilian cc32 strain with phenotype, B: 4,7; P1.19,15 [1,2,[7][8][9]28]. A large proportion of isolates in our study had corresponding OMP sequence types: PorB loop I-4 (serotype 4) and loop VI-9 or VI-24 (serotype 7) [29], PorA VR 1-19 and VR 2-15 (serosubtype PI.…”

Section: Discussionmentioning

confidence: 46%

Correction: Molecular Epidemiology of Neisseria meningitidis Serogroup B in Brazil

Filippis¹,

Lemos²,

Hostetler³

et al. 2012

PLoS ONE

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Background: Neisseria meningitidis serogroup B has been predominant in Brazil, but no broadly effective vaccine is available to prevent endemic meningococcal disease. To understand genetic diversity among serogroup B strains in Brazil, we selected a nationally representative sample of clinical disease isolates from 2004, and a temporally representative sample for the state of Sa ˜o Paulo (1988Paulo ( -2006 for study (n = 372). Methods:We performed multi-locus sequence typing (MLST) and sequence analysis of five outer membrane protein (OMP) genes, including novel vaccine targets fHbp and nadA. Results:In 2004, strain B:4:P1.15,19 clonal complex ST-32/ET-5 (cc32) predominated throughout Brazil; regional variation in MLST sequence type (ST), fetA, and porB was significant but diversity was limited for nadA and fHbp. Between 1988 and 1996, the Sa ˜o Paulo isolates shifted from clonal complex ST-41/44/Lineage 3 (cc41/44) to cc32. OMP variation was associated with but not predicted by cc or ST. Overall, fHbp variant 1/subfamily B was present in 80% of isolates and showed little diversity. The majority of nadA were similar to reference allele 1. Conclusions:A predominant serogroup B lineage has circulated in Brazil for over a decade with significant regional and temporal diversity in ST, fetA, and porB, but not in nadA and fHbp.

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“…Epidemiological studies investigating carriage of N. meningitidis approximately 10 cases per 100 000 population in some parts of the country (particularly in Rio de Janeiro). However, there was another shift back to serogroup B towards the end of the decade which caused approximately 80% of cases 14,19,[48][49][50][51]. Serogroup C was dominant in Argentina from 1995 until the end of the decade 7,14,15,45.…”

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