Antimicrobial susceptibility of gram-positive bacteria isolated in brazilian hospitals participating in the SENTRY Program (2005-2008)

Gales, Ana Cristina; Sader, Hélio S.; Ribeiro, Julival; Zoccoli, Cássia; Barth, Afonso Luís; Pignatari, Antônio Carlos Campos

doi:10.1590/s1413-86702009000200004

Cited by 84 publications

(65 citation statements)

References 33 publications

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“…Overall, moderate rates of high-level resistance to aminoglycosides were observed over the four-year, similar to those observed recently in Brazil of 32.1% and 26.7% and in the USA of 30.6% and 25.2% for streptomycin and gentamicin, respectively 3,34 . Regarding quinolones, resistance rates did not change significantly during the study period, whereas the overall resistance rates to ciprofloxacin were slightly higher compared to Latin America (50%) and the USA (58%) 29,31 .…”

Section: Conflict Of Interest Financial Support Referencessupporting

confidence: 87%

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Trends in antimicrobial resistance among clinical isolates of enterococci in a Brazilian tertiary hospital: a 4-year study

Conceição

Oliveira

Silva

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: In the past two decades members of the genus Enterococcus have emerged as important nosocomial pathogens worldwide. This study prospectively analyzed the distribution of species and trends in antimicrobial resistance among clinical isolates of enterococci in a Brazilian tertiary hospital from 2006-2009. Methods: Enterococcal species were identified by conventional biochemical tests. The antimicrobial susceptibility profile was performed by disk diffusion in accordance with the Clinical and Laboratory Standards Institute (CLSI). A screening test for vancomycin was also performed. Minimal inhibitory concentration (MIC) for vancomycin was determined using the broth dilution method. Molecular assays were used to confirm speciation and genotype of vancomycin-resistant enterococci (VRE). Results: A total of 324 non-repetitive enterococcal isolates were recovered, of which 87% were E. faecalis and 10.8% E. faecium. The incidence of E. faecium per 1,000 admissions increased significantly (p < 0.001) from 0.3 in 2006 to 2.3 in 2009. The VRE rate also increased over time from 2.5% to 15.5% (p < 0.001). All VRE expressed high-level resistance to vancomycin (MIC >256μg/ mL) and harbored vanA genes. The majority (89.5%) of VRE belonged to E. faecium species, which were characteristically resistant to ampicillin and quinolones. Overall, ampicillin resistance rate increased significantly from 2.5% to 21.4% from 2006-2009. Resistance rates for gentamicin, chloramphenicol, tetracycline, and erythromycin significantly decreased over time, although they remained high. Quinolones resistance rates were high and did not change significantly over time. Conclusions: The data obtained show a significant increasing trend in the incidence of E. faecium resistant to ampicillin and vancomycin.

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Section: Conflict Of Interest Financial Support Referencessupporting

confidence: 87%

“…According to the SENTRY Antimicrobial Surveillance Program, enterococci are the fourth most common pathogen of bacteremia in North America and the fifth in Europe 2 . In Brazil, they are the eighth agent of bacteremia overall and the third among the Grampositive cocci 3 .…”

Section: Introductionmentioning

confidence: 99%

Trends in antimicrobial resistance among clinical isolates of enterococci in a Brazilian tertiary hospital: a 4-year study

Conceição

Oliveira

Silva

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…However, the fact that professionals have a higher percentage of MRSA points to contamination in the hospital itself. The SENTRY survey conducted in Brazilian hospitals showed that the resistance of CoNS in blood cultures is 80% 25 ; and in our study, this was the most frequent type of sample.…”

Section: Discussionsupporting

confidence: 63%

“…These percentages may be considered low, as the prevalence of isolation of MRSA strains ranges from 40 to 80% 2,9,24 in Brazilian hospitals, and the data from the Antimicrobial Surveillance Program (SENTRY) show that MRSA corresponds to 31% of the causes of nosocomial and community infections and is considered the most common among the most prevalent pathogens 25 . However, the fact that professionals have a higher percentage of MRSA points to contamination in the hospital itself.…”

Section: Discussionmentioning

confidence: 99%

The occurrence and dissemination of methicillin and vancomycin-resistant Staphylococcus in samples from patients and health professionals of a university hospital in Recife, State of Pernambuco, Brazil

Rabelo

Neto

Loibman

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) strains have been responsible for many nosocomial outbreaks. Within hospitals, colonized employees often act as reservoirs for the spread of this organism. This study collected clinical samples of 91 patients admitted to the intensive care unit (ICU), hemodialysis/nephrology service and surgical clinic, and biological samples from the nasal cavities of 120 professionals working in those environments, of a University Hospital in Recife, in the State of Pernambuco, Brazil. The main objective of this study was to determine the occurrence and dissemination of methicillin-and vancomycin-resistant Staphylococcus spp. Methods: The isolates obtained were tested for susceptibility to oxacillin and vancomycin and detection of the mecA gene. In addition, the isolates were evaluated for the presence of clones by ribotyping-polymerase chain reaction (PCR). Results: MRSA occurrence, as detected by the presence of the mecA gene, was more prevalent among nursing technicians; 48.1% (13/27) and 40.7% (11/27) of the isolates were from health professionals of the surgical clinic. In patients, the most frequent occurrence of mecA-positive isolates was among the samples from catheter tips (33.3%; 3/9), obtained mostly from the hemodialysis/nephrology service. Eight vancomycin-resistant strains were found among the MRSA isolates through vancomycin screening. Based on the amplifi cation patterns, 17 ribotypes were identifi ed, with some distributed between patients and professionals. Conclusions: Despite the great diversity of clones, which makes it diffi cult to trace the source of the infection, knowledge of the molecular and phenotypic profi les of Staphylococcus samples can contribute towards guiding therapeutic approaches in the treatment and control of nosocomial infections.

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“…(10) Piper ve ark. (19) infektif endokarditli olgulardan izole ettikleri 32'si penisiline dirençli Streptococcus pneumoniae olmak üzere çeşitli tür-lerden 82 Streptococcus; 32 metisiline dirençli S.aureus; 38 vankomisine dirençli enterokok; 32 başka Gram pozitif bakteri suşlarının daptomisin duyarlılığını incelemişlerdir.…”

Section: Bulgularunclassified

Daptomycin Susceptibility in Gram Positive Cocci Isolated from Intensive Care Units

Şamlıoğlu¹,

Ece²,

Atalay³

et al. 2011

Ankem

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ÖZET Anahtar sözcükler: daptomisin, E-test, Gram pozitif koklar, yoğun bakım birimleri SUMMARY Daptomycin Susceptibility in Gram Positive Cocci Isolated from Intensive Care Units The sensitivities of 151 Gram positive cocci isolated from intensive care units of Tepecik Education and Research Hospital between April 16 and December 15, 2010 were determined by E-test for daptomycin and by disk diffusion and Vitek-2 system for other antibiotics. The strains consisted of methicilin sensitive and resistant staphylococci and enterococci.Daptomycin was found to be active on all strains like linezolid, and vancomycin and teicoplanin which were active on the strains except four Enterococcus faecium followed these two antibiotics.

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Antimicrobial susceptibility of gram-positive bacteria isolated in brazilian hospitals participating in the SENTRY Program (2005-2008)

Cited by 84 publications

References 33 publications

Trends in antimicrobial resistance among clinical isolates of enterococci in a Brazilian tertiary hospital: a 4-year study

Trends in antimicrobial resistance among clinical isolates of enterococci in a Brazilian tertiary hospital: a 4-year study

The occurrence and dissemination of methicillin and vancomycin-resistant Staphylococcus in samples from patients and health professionals of a university hospital in Recife, State of Pernambuco, Brazil

Daptomycin Susceptibility in Gram Positive Cocci Isolated from Intensive Care Units

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