Epidemiological aspects of hepatitis C in Brazil

Diament, Décio

doi:10.1590/s1413-86702007000700002

Cited by 6 publications

(6 citation statements)

References 2 publications

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“…Also, subtype 1b is associated with a higher rate of chronic active hepatitis or cirrhosis, and with a poorer response to treatment with α-interferon than genotypes 2 or 3 [16]. In this study, all patients were naïve and two subtype 1a patients, as well as one subtype 1b patient had cirrhosis.…”

Section: Resultsmentioning

confidence: 91%

“…Distribution of cases of chronic hepatitis C by transmission routes from 1998 to 2006 showed 21% of cases associated with intravenous drug use and 16% with blood transfusion, but in 40% of cases there was not any known risk factor [16]. An extensive review on HCV infection data in Brazil showed the following prevalence in healthy adults and/or blood donors in the different Brazilian regions: 0.9 to 2.4% (North), 1.7 to 3.4% (Northeast), 1.0 to 1.4% (Middle West), 0.8 to 2.8% (Southeast) and 1.1 to 2.1% (South) [17].…”

Section: Introductionmentioning

confidence: 99%

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Distribution of hepatitis c virus (hcv) genotypes in patients with chronic infection from Rondônia, Brazil

Vieira

Alvarado-Mora

Botelho

et al. 2011

Virol J

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BackgroundHepatitis C virus (HCV) is an important human pathogen affecting around 3% of the human population. In Brazil, it is estimated that there are approximately 2 to 3 million HCV chronic carriers. There are few reports of HCV prevalence in Rondônia State (RO), but it was estimated in 9.7% from 1999 to 2005. The aim of this study was to characterize HCV genotypes in 58 chronic HCV infected patients from Porto Velho, Rondônia (RO), Brazil.MethodsA fragment of 380 bp of NS5B region was amplified by nested PCR for genotyping analysis. Viral sequences were characterized by phylogenetic analysis using reference sequences obtained from the GenBank (n = 173). Sequences were aligned using Muscle software and edited in the SE-AL software. Phylogenetic analyses were conducted using Bayesian Markov chain Monte Carlo simulation (MCMC) to obtain the MCC tree using BEAST v.1.5.3.ResultsFrom 58 anti-HCV positive samples, 22 were positive to the NS5B fragment and successfully sequenced. Genotype 1b was the most prevalent in this population (50%), followed by 1a (27.2%), 2b (13.6%) and 3a (9.0%).ConclusionsThis study is the first report of HCV genotypes from Rondônia State and subtype 1b was found to be the most prevalent. This subtype is mostly found among people who have a previous history of blood transfusion but more detailed studies with a larger number of patients are necessary to understand the HCV dynamics in the population of Rondônia State, Brazil.

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Section: Resultsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Distribution of hepatitis c virus (hcv) genotypes in patients with chronic infection from Rondônia, Brazil

Vieira

Alvarado-Mora

Botelho

et al. 2011

Virol J

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“…A number of studies indicate high prevalence of genotype 1 in Brazil (Diament, 2007;Perrone et al, 2008). Since the sample consisted of patients who used PEG-IFN, a higher percentage of patients with genotype 1 was expected.…”

Section: Discussionmentioning

confidence: 99%

Sustained virological response to treatment of chronic hepatitis C with peginterferon alfa and ribavirin

Rosa

Blatt

Peres

et al. 2012

Braz. J. Pharm. Sci.

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This study aimed to evaluate the rate of sustained virological response (SVR) and the clinical and treatment characteristics of patients with chronic hepatitis C (CHC). A retrospective uncontrolled cohort study was conducted among patients who received treatment for CHC between 2005 and 2008 attended at the Center for the Application and Monitoring of Injectable Medications, in Florianopolis, SC, Brazil. The inclusion criteria were: patients over 18 years of age, with a confirmed diagnosis of chronic hepatitis C according to Brazilian guidelines, treated with PEG-IFN alfa-2a or 2b associated with RBV. A total of 188 patients were included in the study: 70% men, 59% genotype 1, 27% coinfected with HIV, 31% with cirrhosis. The SVR rate, calculated by probability theory, was determined as 26% (max=57.4% and min=12.8%) and the intention to treat was 12.8%. Associations between Sustained Virological Response (SVR) and the variables sex (p=0.017), age (p=0.003), genotype (p=0.648) and cirrhosis (p=0.275), were determined in the bivariate analysis and only sex and age were significantly associated with SVR. The SVR rate was considered low, which can be partially explained by patients' unfavorable pretreatment characteristics.Uniterms: Hepatitis C. Hepatitis C Chronic. Effectiveness. Interferon alfa-2a. Interferon alfa-2b.O objetivo do estudo foi avaliar a taxa de resposta viral sustentada (RVS) e as características clínicas e do tratamento dos pacientes portadores de hepatite C crônica. Realizou-se uma coorte retrospectiva não controlada com recorte temporal dos anos de 2005 a 2008, dos pacientes atendidos no Polo de Aplicação e Monitoramento de Medicamentos Injetáveis, em Florianópolis, SC. Os critérios de inclusão foram: pacientes maiores de 18 anos, com diagnóstico confirmado de hepatite C crônica de acordo com o protocolo brasileiro, tratados com PEG-IFN alfa-2a ou 2b associado a ribavirina. Total de 188 pacientes foi incluído no estudo, 70% homens, 59% genótipo 1, 27% co-infectados com o HIV e 31% apresentando cirrose. A taxa de RVS calculada através da teoria das probabilidades foi de 26% (max=57,4% and min=12,8%) e por intenção de tratamento de 12,8%. Verificou-se a associação da RVS com as variáveis: sexo (p=0,017), idade (p=0,003), genótipo (p=0,648) e presença de cirrose (p=0,275). Somente sexo e idade foram associados significativamente com a RVS. A taxa de RVS foi considerada baixa e, em parte, pode ser explicada pelas características desfavoráveis dos pacientes para a obtenção de RVS.Unitermos: Hepatite C. Hepatite C Crônica. Efetividade. Interferona alfa-2a. Interferona alfa-2b.

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“…According to this survey, it is estimated that about 2 million people in Brazil are living with chronic hepatitis C. 23 Most of them are unaware of their serological status, and data from the SINAN identify 82 041 new patients with hepatitis C diagnosed between 1999 and 2011, 67.3% of them from the southeast region. 16,44…”

Section: Current Information Available On the Epidemiology Of Hepatitmentioning

confidence: 99%

“…37,[40][41][42][43] According to this survey, it is estimated that about 2 million people in Brazil are living with chronic hepatitis C. 23 Most of them are unaware of their serological status, and data from the SINAN identify 82 041 new patients with hepatitis C diagnosed between 1999 and 2011, 67.3% of them from the southeast region. 16,44 Moreover, since the 80s, an increase in the mortality rate was observed due to hepatitis B. After 1996, with the notification of HCV, it was possible to identify progressive mortality rates due to hepatitis C. 45 The mortality rate due to hepatitis C increased from 0.14 deaths per 100 000 people in 1996 to 0.73 in 2003.…”

Section: Current Information Available On the Epidemiology Of Hepatitmentioning

confidence: 99%

12 Years of Universal Access to Hepatitis C Treatment

Naveira¹,

Barbosa

Sereno

et al. 2014

J Int Assoc Provid AIDS Care

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Hepatitis C is considered one of the most neglected diseases in world. Worldwide about 150 million people are chronically infected by hepatitis C virus (HCV), and 60% to 70% of them will develop severe liver disease. This article describes Brazil's response to hepatitis C, from the first steps in 1993 to a national program in 2002. We reviewed the available literature, most of it in Brazilian Portuguese, and compiled them in order to share this experience with those seeking some pragmatic solutions. After 12 years, the national program has achieved universal coverage of treatment, resulting in saved lives and resources for the health system. There is abundant evidence that the HCV epidemic deserves attention. The overall consequence of long-term HCV infection is a negative impact on the health care economy. The Brazilian experience can be adapted to many countries in the world, in compliance with the 2010 World Health Organization World Health Assembly Resolution.

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Epidemiological aspects of hepatitis C in Brazil

Cited by 6 publications

References 2 publications

Distribution of hepatitis c virus (hcv) genotypes in patients with chronic infection from Rondônia, Brazil

Distribution of hepatitis c virus (hcv) genotypes in patients with chronic infection from Rondônia, Brazil

Sustained virological response to treatment of chronic hepatitis C with peginterferon alfa and ribavirin

12 Years of Universal Access to Hepatitis C Treatment

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