Psychosis during peginterferon-alpha2a and ribavirin therapy: case report

Quarantini, Lucas de Castro; Cruz, Simone Cunha; Batista-Neves, Susana; Paraná, Raymundo; Miranda-Scippa, Ângela; Bressan, Rodrigo Affonseca

doi:10.1590/s1413-86702006000600010

Cited by 19 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, previous reports suggest that interferon therapy negatively affects HRQOL of patients with chronic hepatitis C during the initial 12-24 weeks of treatment and is associated with several psychiatric and neurological side effects [Neary et al, 1999;Quarantini et al, 2006aQuarantini et al, , 2006bQuarantini et al, , 2007. Importantly, the present results were not influenced by the patients or the clinician knowledge of the response to treatment, since both were blind to the HCV polymerase chain reaction status.…”

Section: Discussioncontrasting

confidence: 85%

The effect of early virological response in health‐related quality of life in HCV‐infected patients

Miranda-Scippa

Batista-Neves

Galvão-de-Almeida

et al. 2008

Journal of Medical Virology

Self Cite

View full text Add to dashboard Cite

Twenty-nine HCV-infected patients were treated with pegylated interferon alpha. Diagnosis was based on serum HCV RNA-PCR positive results and liver biopsy. All patients had elevated serum levels of alanine aminotransferase at the time of the study, but liver disease was compensated. Patients were evaluated at baseline treatment and after 4 and 12 weeks of antiviral treatment with the Medical Outcomes Study 36-item Short-Form Health Survey. The Mini-International Neuropsychiatric Interview was used to exclude previous or current psychiatric diagnoses. Both patients and psychiatrists were blind to the HCV RNA status, and serum HCV RNA test results only became available after the visit at week 12. After antiviral treatment, 16 patients (55.2%) were classified as nonresponders and 13 (44.8%) were classified as responders. When compared to nonresponders, responders had a greater improvement in the HRQOL scores for the mental health domain (P < .019). Differences in other domains were not significant. The present study confirms that active viral infection is one possible reason for the poor Health-Related Quality of Life in this population.

show abstract

Section: Discussioncontrasting

confidence: 85%

The effect of early virological response in health‐related quality of life in HCV‐infected patients

Miranda-Scippa

Batista-Neves

Galvão-de-Almeida

et al. 2008

Journal of Medical Virology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Other authors who have also used a standardized diagnostic interview have demonstrated that depression is associated with low SF-36 scores; although in these studies HCV-infected patients undergoing treatment with IFN were not excluded, which could have interfered negatively in the assessment of HRQOL and increased the incidence of psychiatric events [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Impact of psychiatric disorders on the quality of life of brazilian HCV-infected patients

Batista-Neves¹,

Almeida²,

Cardeal³

et al. 2009

Braz J Infect Dis

Self Cite

View full text Add to dashboard Cite

The aim of our study was to determine the impact of psychiatric comorbidities on the health-related quality of life of HCV-infected patients. Assessment of clinical, socio-demographic and quality of life data of the patients followed up at a Hepatology unit was performed by using a standard questionnaire and the SF-36 instrument. Psychiatric diagnoses were confirmed by using the Mini International Neuropsychiatric Interview, Brazilian version 5.0.0 (MINI Plus). Evaluation using the MINI plus demonstrated that 46 (51%) patients did not have any psychiatric diagnosis, while 44 (49%) had at least one psychiatric diagnosis. Among patients with a psychiatric comorbidity, 26 (59.1%) had a current mental disorder, out of which 22 (84.6%) had not been previously diagnosed. Patients with psychiatric disorders had lower scores in all dimensions of the SF-36 when compared to those who had no psychiatric diagnosis. Scores of physical functioning and bodily pain domains were lower for those suffering from a current psychiatric disorder when compared to those who had had a psychiatric disorder in the past. Females had lower scores of bodily pain and mental health dimensions when compared to males. Scores for mental health dimension were also lower for patients with advanced fibrosis. The presence of a psychiatric comorbidity was the variable that was most associated with the different scores in the SF-36, compared to other variables such as age, gender, aminotransferase levels, and degree of fibrosis.

show abstract

“…Psicose que é um raro sintoma relacionado ao tratamento imuno-modulatório, foi evidenciada em estudo caso controle de pacientes com hepatite C que fizeram uso terapêutico de interferon (IFN) recombinante (QUARANTINI et al, 2006).…”

Section: Resultsunclassified

Fisiopatologia imuno-inflamatória do delirium: revisão da literatura

Chalhub

Quarantini²

2011

cmbio

View full text Add to dashboard Cite

RESUMOO delirium, marcador de disfunção orgânica cerebral, está presente de maneira frequente na prática clínica e tem importância prognóstica aumentando morbi-mortalidade em diversos cenários clínicos e cirúrgicos de pacientes internados em unidades de terapia intensiva. Objetivo: Elucidar quais as principais alterações imuno-inflamatórias relacionadas ao delirium através de uma revisão não sistemática da literatura. Metodologia: Busca no banco de dados PubMed, utilizando os seguintes unitermos: "delirium", "inflammation", e "cytokines", nos últimos 5 anos, publicados em idioma inglês. Sumarizamos as evidências encontradas relacionadas a fisiopatologia imuno-inflamatória do delirium. Resultado: Mecanismos imunoinflamatórios têm sido propostos para elucidação fisiopatológica do delirium, dentre eles o papel de citocinas pró e antiinflamatórias, a ativação microglial, a quebra da barreira hemato-encefálica e o desequilíbrio do eixo hipotálamo-hipófise-adrenal. Conclusão: No estudo do delirium e de sua fisiopatologia, os mecanismos imuno-inflamatórios parecem ter papel importante na sua gênese, contudo, mais estudos são necessários para elucidar melhor esta relação. Palavras-chave: Delirium. Inflamação. Citocinas. ABSTRACTDelirium is a severity marker of brain dysfunction. It is prevalent among clinical and surgical patients, with a high impact on morbidity and mortality in distinct scenarios in intensive care patients. Objective: To elucidate the most important findings about the pathophysiology of immune-inflammatory pathways of delirium in the literature. Methods: Search in the PubMed using the terms: "delirium", "inflammation" and "cytokines" in the last 5 years, in Engli sh idiom. Results: Many immune-inflammatory pathways have been proposed to explain delirium. Some of the main physiopat hology mechanisms are: the cytokines, the breakdown of the brain-blood barrier, and a misbalance of the hypothalamus-pituitaryadrenal axis. Conclusion: In the study of delirium and its pathophysiology it seems that the immune-inflammatory pathways play a critical role in its genesis, but more studies are needed to better elucidate this relationship.

show abstract

Psychosis during peginterferon-alpha2a and ribavirin therapy: case report

Cited by 19 publications

References 15 publications

The effect of early virological response in health‐related quality of life in HCV‐infected patients

The effect of early virological response in health‐related quality of life in HCV‐infected patients

Impact of psychiatric disorders on the quality of life of brazilian HCV-infected patients

Fisiopatologia imuno-inflamatória do delirium: revisão da literatura

Contact Info

Product

Resources

About