Antibacterial activity of Brazilian Amazon plant extracts

Suffredini, Ivana Barbosa; Paciência, Mateus Luís Barradas; Varella, Antonio Drauzio; Younes, Riad Naim

doi:10.1590/s1413-86702006000600008

Cited by 40 publications

(22 citation statements)

References 7 publications

(9 reference statements)

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“…73 (1) , but when the natural product was associated with the aminoglycosides, a synergistic or antagonistic antibiotic activity was detected against both bacterial strains assayed. When compared with the results of SUFFREDINI et al (2006), the results observed on this work indicate a better antibacterial activity.…”

Section: Resultssupporting

confidence: 57%

Modulatory antimicrobial activity of piper arboreum extracts

Tintino¹,

Souza²,

Guedes³

et al. 2014

Acta Botanica Croatica

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-The side effects of certain antibiotics have been a recent dilemma in the medical arena. Due this fact, the necessity of natural product discovery could provide important indications against several pharmacological targets and combat many infectious agents. Piper arboreum Aub. (Piperaceae) has been used by Brazilian traditional communities against several illnesses including rheumatism, bronchitis, sexually transmitted diseases and complaints of the urinary tract. Medicinal plants are a source of several remedies used in clinical practice to combat microbial infections. In this study, ethanol extract and fractions of Piper arboreum leaves were used to assay antimicrobial and modulatory activity. The minimum inhibitory concentration (MIC) was determined using microdilution method of ethanol extract and fractions from the leaves of P. arboreum ranging between 8 and 1024 mg mL -1 . The capacity of these natural products to enhance the activity of antibiotic and antifungal drugs was also assayed. In these tests, natural products were combined with drugs. The natural products assayed did not demonstrate any clinically relevant antimicrobial activity (MIC ³ 1024 mg mL -1 ). However, the modulation of antibiotic activity assay observed a synergistic activity of natural products combined with antifungal (such as nystatin and amphotericin B) and antibiotic drugs (such as amikacin, gentamicin and kanamycin). According to these results, these natural products can be an interesting alternative not only to combat infectious diseases caused by bacteria or fungi, but also to combat enhanced resistance of microorganisms to antibiotic and antifungal drugs.

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Section: Resultssupporting

confidence: 57%

Modulatory antimicrobial activity of piper arboreum extracts

Tintino¹,

Souza²,

Guedes³

et al. 2014

Acta Botanica Croatica

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“…Although it is not recommended to compare the biological activity of standard drugs such as fluconazole with the activity of a complex mixture of substances (Suffredini et al, 2006), the zones of inhibition of crude extracts for C. erythrocarpos and S. ellipticum and fractions DS 3 and DS 5 against A. niger were relatively comparable to that of fluconazole. The MIC and MFC values for these extracts were, however, not comparable to the standard except for fraction DS 3, which was relatively comparable against C. albicans.…”

Section: Discussionmentioning

confidence: 99%

Screening of traditionally used Tanzanian medicinal plants for antifungal activity

Kisangau

Hosea

Lyaruu

et al. 2009

Pharmaceutical Biology

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“…Compared to the antibacterial activities from other plant extracts, several C. bernieri extracts were more efficient than methanolic aerial part extracts of Inula viscosa against B. subtilis (MIC=25 mg/ml, MBC=50 mg/ml) and S. aureus (MIC=12.5 mg/ml, MBC=50 mg/ml) (Larbi et al, 2016). By contrast, tuber ethyl acetate extract of Tropaeolum pentaphyllum against E. coli (MIC=0.02 mg/ml, MBC=0.64 mg/ml), P. aeruginosa (MIC=0.04 mg/ml, MBC=0.64 mg/ml) (da Cruz et al, 2016) and organic extract (aerial parts) of Rapanea parvifolia against E. faecalis (MIC=0.03 mg/ml, MBC=0.06 mg/ml) (Suffredini et al, 2006) were more efficient. On fungi, LME (MIC=0.097 mg/ml, MFC=0.195 mg/ml) was more efficient than leaf methanolic extract of Myrtus nivellei against C. albicans (MIC=4.5 mg/ml) (Touaibia and Chaouch, 2015) whereas LME, SEA and SME against C. guilliermondii (MIC=0.08 mg/ml, MFC=0.32 mg/ml) were less efficient than ethyl acetate extract of T.…”

Section: Discussionmentioning

confidence: 89%

Antimicrobial activity of extracts from Crotalaria bernieri Baill. (Fabaceae)

Andriamampianina¹,

Rakoto²,

Petit³

et al. 2016

Afr. J. Microbiol. Res.

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This work was designed to study the antimicrobial activity of Crotalaria bernieri Baill. (Fabaceae). Extracts from leaf, root, pod and seed using hexane, ethyl acetate and methanol were tested in vitro for their activity against 17 bacteria, 5 fungi (3 yeasts and 2 molds) using disc diffusion and micro dilution methods. At the concentration of 1 mg/disc, all the extracts exhibited antimicrobial activity depending on the plant part and the extraction method used. The most sensitive germs were Salmonella enteridis, Streptococcus pyogenes and Candida guilliermondii with inhibition zone diameter (IZD) of 11 mm, 15 mm and 13 mm respectively. Most of extracts showed, broad activity spectrum varying from one extract to another. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) of all extracts were recorded. Ten extracts displayed an excellent effect (MIC < 100 µg/ml), 8 a moderate effect (MIC from 100 to 500 µg/ml), 5 a weak effect (MIC from 500 to 1000 µg/ml) and the others were ineffective (MIC > 1000 µg/ml). Leaf methanol extracts were the most efficient and Gram positive bacteria the most sensitive. All extracts had bactericidal (MBC/MIC ≤ 4) or fungicidal action (MFC/MIC ≤ 4) in certain microorganisms and bacteriostatic (MBC/MIC > 4) or fungistatic action (MFC/MIC > 4) in others. Antimicrobial activity might be due to tannins, polyphenols, steroids, triterpenes and flavonoids that were present in most of the plant organs, but alkaloids in leaf and pod and saponosides in root might also be involved. C. bernieri with the effectiveness of all its parts, the variety of its secondary metabolites, the great number of sensitive pathogen microorganisms and its ubiquity make this plant species an interesting source of antimicrobial agents.

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Antibacterial activity of Brazilian Amazon plant extracts

Cited by 40 publications

References 7 publications

Modulatory antimicrobial activity of piper arboreum extracts

Modulatory antimicrobial activity of piper arboreum extracts

Screening of traditionally used Tanzanian medicinal plants for antifungal activity

Antimicrobial activity of extracts from Crotalaria bernieri Baill. (Fabaceae)

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