Screening of traditionally used Tanzanian medicinal plants for antifungal activity

Kisangau, Daniel P.; Hosea, Ken M.; Lyaruu, Herbert V. M.; Joseph, Cosam C.; Mbwambo, Zakaria H.; Masimba, Pax J.; Gwandu, Catherine B.; Bruno, Lenta Ndjakou; Devkota, Krishna Prasad; Sewald, Norbert

doi:10.1080/13880200902933039

Cited by 23 publications

(16 citation statements)

References 27 publications

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“…Additionally, Rumex usambarensis (Dammer) has not been investigated on its pain alleviating properties though reported to be used in traditional medicine (Kisangau et al, 2009) (Table 2). On the hand, Strychnos henningsii Gilg., Carissa spinarum L. and Zanthoxylum chalybeum Engl.…”

Section: Discussionmentioning

confidence: 99%

“…Leave extract has some antifungal activity (Kisangau et al, 2009) Concoction taken in peptic ulcers and diarrhoea (Boer et al, 2005). Leaves used for coughs, stomach pains and decoction of whole plant used to treat small pox as a bath (Kokwaro, 1993;Schlage et al, 2000) Salvadora persica (Salvadoraceae) Antibacterial activity; alkaloid salvadorine (Almas and Al-Bagieh, 1999) Root decoction used to cure abdominal pains, chest diseases, wounds and young stems used as toothbrush (Kokwaro, 1993) Schkuhria pinnata (Asteraceae) Antibacterial, anti-inflammatory activities (Luseba et al, 2007).…”

Section: Rumex Usambarensis (Polygonaceae)mentioning

confidence: 99%

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Medicinal plants used in the management of chronic joint pains in Machakos and Makueni counties, Kenya

Wambugu

Mathiu

Gakuya

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Rumex Usambarensis (Polygonaceae)mentioning

confidence: 99%

Medicinal plants used in the management of chronic joint pains in Machakos and Makueni counties, Kenya

Wambugu

Mathiu

Gakuya

et al. 2011

Journal of Ethnopharmacology

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“…The methanolic extract has been found to be hepato-protective [20]. Anti-fungal activities of dichloromethane and aqueous bark extracts of Sapium ellipticum have been carried out in Tanzania [19]. But, to the best of our knowledge, antibacterial activities of methanolic extracts of this plant are reported here for the first time.…”

Section: Cussonia Arborea (Ca) Dissotis Longipetala (Dl Lonchocarpusmentioning

confidence: 99%

“…The antimicrobial mechanism of action of the alkaloids may be through DNA intercalation and inhibition of DNA synthesis through topoisomerase inhibition [18]. Some studies have been done on the isolation and characterization of biological active components of this specie [19] but very few studies have reported the antimicrobial activities of this plant. The methanolic extract has been found to be hepato-protective [20].…”

Section: Cussonia Arborea (Ca) Dissotis Longipetala (Dl Lonchocarpusmentioning

confidence: 99%

Antimicrobial Activities of Some Medicinal Plants Against Multiresistants Microorganisms Causing Urogenital Tract Infections in Cameroon

Merveille¹

2017

JDMP

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Abstract:Urogenital tract infections remain a serious global treat especially in women. The control of these infections is increasingly complicated due to development of resistance against available drugs. Therefore a perpetual search of new antimicrobial molecules is needed to face the challenge of microbial resistance. This study was initiated to screen the antimicrobial activities of methanol extracts of nine Cameroonian medicinal plants, used for the treatment of infectious diseases, against multiresistant pathogens isolated from urogenital infected patients. The plants included: Cussonia arborea, Dissotis longipetala, Lonchocarpus sepium, Nauclea pobeguinii, Picralima nitida, Rumex abyssinicus, Rumex berqueatii, Sapium ellypticum, Psorospermum febrifigum, They were tested on seven strains including six clinical isolates (Escherichia coli, Proteus vulgaris, Providencia stuartii, Pseudomonas aeruginosa, Staphylococcus saprophiticus, Candida krusei) and one reference strain (E. coli JM109). Clinical strains were checked for their multiresistance using disc diffusion method. The antimicrobial activities were determined by agar well diffusion method. MICs were determined using microdilution assay. The phytochemical screening of plants was also done. All the bacteria strains were found to be multidrug-resistant (MDR) against at least 7 of the 12 antibiotics tested. Antimicrobial activities demonstrated that 6/9 (SE, DL, RA, RB, PN, LS) plants were active on at least six microorganisms. MICs ranged from 0.125 to 128mg/ml for crude extracts, from 0.5 to 0.16µg/ml for gentamicin and was 0,002mg/ml for fluconazole. One extract (NP) which showed limited results on agar, inhibited the growth of all the strains with MICs ranging from 1to 16mg/ml showing a limited activity of this extract on agar. We found that four extracts (SE, NP, RA, DL) have significant activities since they presented MICs ≤ 8mg/ml on at least 5 tested microorganism individually. Findings from phytochemical screening showed that most active extracts contain tannins, alkaloids and saponins which could be responsible of these activities.

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“…Pharmacological studies on L. schimperi bark, leaf, root, and stem extracts exhibited potent in vitro and in vivo pharmacological activities including anesthetic [79], antibacterial [79,86], antifungal [86,87], anticoccidial [88], anti-inflammatory [82], antinoceceptive [82], antioxidant [83], anti-trypanosomal [89], antiulcerogenic [79], cytotoxicity [77,79,81,90], and toxicity [8,79] activities.…”

Section: Pharmacological Properties Of L Schimperimentioning

confidence: 99%

Lannea Schimperi: Review of Its Botany, Medicinal Uses, Phytochemistry, and Biological Activities

Maroyi

2019

Asian J Pharm Clin Res

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Lannea schimperi is a well-known fruit tree and medicinal plant in tropical Africa. The current study critically reviewed the botany, medicinal uses, phytochemistry, and pharmacological activities of L. schimperi. Literature on botany, medicinal uses, phytochemical and biological activities of L. schimperi were collected from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, PubMed, BMC, ScienceDirect, and Scopus. Complementary information was gathered from pre-electronic sources such as books, book chapters, theses, scientific reports, and journal articles obtained from the University Library. This study revealed that the species is used as a source of fiber, edible fruits, and herbal medicine. Phytochemical compounds identified from the species include cyclohexenones, cardanols, alkaloids, anthocyanins, anthracene glycosides, carbohydrates, cardiac glycosides, carotenoids, condensed tannins, coumarins, flavonoids, phenolic glycosides, phenols, polyoses, polyuronoids, reducing sugars, saponins, steroids, tannins, triterpenoids, and volatile compounds. Pharmacological research revealed that extracts and phytochemical constituents isolated from L. schimperi have anesthetic, antibacterial, antifungal, anticoccidial, anti-inflammatory, antinociceptive, antioxidant, anti-trypanosoma, antiulcerogenic, cytotoxicity, and toxicity activities. L. schimperi should be subjected to detailed phytochemical, pharmacological, and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities of the species.

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Screening of traditionally used Tanzanian medicinal plants for antifungal activity

Cited by 23 publications

References 27 publications

Medicinal plants used in the management of chronic joint pains in Machakos and Makueni counties, Kenya

Medicinal plants used in the management of chronic joint pains in Machakos and Makueni counties, Kenya

Antimicrobial Activities of Some Medicinal Plants Against Multiresistants Microorganisms Causing Urogenital Tract Infections in Cameroon

Lannea Schimperi: Review of Its Botany, Medicinal Uses, Phytochemistry, and Biological Activities

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