Weil's disease: an unusually fulminant presentation characterized by pulmonary hemorrhage and shock

Spichler, Anne; Moock, Marcelo; Chapola, Erica G. B.; Vinetz, Joseph M.

doi:10.1590/s1413-86702005000400011

Cited by 18 publications

(19 citation statements)

References 18 publications

(27 reference statements)

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“…Doxycycline 100 mg twice daily for ten days is also recommended. Tetracycline's and Doxycycline are effective but contraindicated in patients with renal insufficiency, in children and pregnant or breastfeeding women [58,59]. Erythromycin has also been found effective in severe leptospirosis [57].…”

Section: Treatment and Prophylaxismentioning

confidence: 99%

A Review of Laboratory Diagnosis and Treatment of Leptospirosis

Al-orry¹,

Arahou²,

Hassikou³

et al. 2016

Int J Pharm Pharm Sci

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Leptospirosis is an infectious disease affect human and animal. The diagnosis is challenging due to none specific clinical features, lack of awareness and poor access to health care. Therefore the disease becomes underreported. Early diagnosis is essential because antibiotic treatment is most effective when it is initiated early. However, laboratories tests for early diagnosis still lacking. The disease may be demonstrated by direct or indirect methods. Direct methods are the detection of the organism or its components and indirect methods are the detection of specific antibodies of the organism. This review highlights the major diagnostic techniques in leptospirosis with their advantages and disadvantages as well as the treatment. The search criteria focused on the thesis we obtained and searching in the websites (Google

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Section: Treatment and Prophylaxismentioning

confidence: 99%

A Review of Laboratory Diagnosis and Treatment of Leptospirosis

Al-orry¹,

Arahou²,

Hassikou³

et al. 2016

Int J Pharm Pharm Sci

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“…Many cases of severe leptospirosis do not conform to this classic description [4••,5,46]. Indeed, severe disease may present as a fulminant monophasic illness with fever progressing to jaundice, oliguric renal failure, pulmonary hemorrhage, refractory shock, and death within days [46] (Table 2). In such situations, which occur most often among people living in urban slums, a high index of suspicion is needed to initiate appropriate empiric antimicrobial therapy and to institute supportive intensive care unit management (Fig.…”

Section: Clinical Presentations Of Leptospirosis: Importance Of Outbrmentioning

confidence: 99%

“…Given the detailed, comprehensive population surveillance carried out in this investigation, it is reasonable to conclude that SPFL was not prominent in Salvador in the early to mid-1990s. However, in other urban areas of Brazil, including São Paulo and Rio de Janeiro, SPFL was first noted to emerge in the early 1990s and remains an important complication of leptospiral infection [46,53,54]. Recently, SPFL has also been observed to be emerging in Salvador as a complication of leptospirosis (Ko, personal communication).…”

Section: Pulmonary Hemorrhage In Leptospirosismentioning

confidence: 99%

Leptospirosis in the tropics and in travelers

Ricaldi¹,

Vinetz

2006

Curr Infect Dis Rep

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Leptospirosis, caused by spirochetes of the genus Leptospira, has increasingly been recognized to affect travelers and residents in tropical settings. A zoonotic disease, leptospirosis is transmitted to humans through environmental surface waters contaminated by the urine of chronically infected mammals. Outcome of infection varies, ranging from acute febrile illness (including self-resolving undifferentiated fever) to aseptic meningitis to a fulminant syndrome of jaundice, oliguric renal failure, pulmonary hemorrhage, and refractory shock. Hospitalized cases have mortality rates as high as 25%. A recent clinical trial showed that third-generation cephalosporin is as effective as doxycycline and penicillin in the treatment of acute disease. Doxycycline is effective in preventing leptospirosis in travelers. No protective vaccine is currently available.

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“…interrogans serovars Copenhageni and Icterohaemorrhagiae ( 8 ), and the syndrome has been identified in diverse settings, including the Andaman Islands. Recent outbreaks have occurred in Nicaragua and Brazil ( 4 , 5 ). SPHS pathogenesis remains poorly understood.…”

mentioning

confidence: 99%

“…A potential parallel is the emergence of SPHS in Salvador, Brazil, in 2003. No cases were identified before 2003, but 47 cases and a 75% case-fatality rate were identified during 2003–2005 ( 4 , 5 ). The entrenched active surveillance and physician awareness of SPHS in neighboring Brazilian cities suggests it is unlikely that this observation stemmed from prior underrecognition of disease; instead, it suggests de novo emergence.…”

mentioning

confidence: 99%