The influence of occult infection with hepatitis B virus on liver histology and response to interferon treatment in chronic hepatitis C patients

Silva, Cláudia Bezerra da; Gonçales, Neiva Sellan Lopes; Pereira, Josiane Silveira Felix; Escanhoela, Cecília Amélia F.; Pavan, Maria Helena Postal; Gonçales, Fernando Lopes

doi:10.1590/s1413-86702004000600007

Cited by 27 publications

(31 citation statements)

References 49 publications

(71 reference statements)

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“…The prevalence of occult B infection in this study was 9 (4.4%), which is higher than some studies (9,33) ; however, it should be stated that the results of some other researches showed a higher prevalence of OBI (8) . Sodhi et al (34) estimated that OBI incidence among 244 HBsAgnegative cancer patients before receiving chemotherapy was 1.9% (13 out of 690).…”

Section: Discussioncontrasting

confidence: 84%

Prevalence of Occult Hepatitis B Infection in Iranian Cancer Patients Before Chemotherapy Treatment

Baghbanian

Halvani

Roghani

et al. 2016

Arq. Gastroenterol.

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Background Occult hepatitis B infection is characterized by negative hepatitis B surface antigen (HBsAg) and also detectable hepatitis B virus (HBV) -DNA, with or without hepatitis B core antibody (anti-HBc). HBV reactivation in individuals under immunosuppressive therapy is critical, occurring in occult HBV. Objective In this study, we aimed to determine the prevalence of occult HBV infection among hepatitis B surface antigen negative in cancer patients before receiving chemotherapy. Methods Sera from 204 cancer patients who were negative for HBsAg, were tested for anti-HBc antibodies. The samples that were negative for HBsAg but positive for anti-HBc also examined for HBV-DNA by polymerase chain reaction (PCR). Results Of the 204 HBsAg negative blood samples, 11 (5.4%) samples were positive for anti-HBc antibodies. HBV-DNA was detected in 9/11 (81%) of anti-HBc positive samples. Occult HBV infection in hematological cancers was more than solid cancers, 4.8% and 4.3% respectively. There was no significant difference in HBc antibody positivity based on vaccination, previous blood transfusions, history of familial hepatitis or biochemical parameters (ALT, AST, total and direct bilirubin levels) (P>0.05). Conclusion Screening of occult HBV infection by HBsAg, HBV DNA and anti HB core antibody should be suggested as a routine investigation in cancer patients before receiving chemotherapy.

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Section: Discussioncontrasting

confidence: 84%

Prevalence of Occult Hepatitis B Infection in Iranian Cancer Patients Before Chemotherapy Treatment

Baghbanian

Halvani

Roghani

et al. 2016

Arq. Gastroenterol.

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“…Occult HBV infection has received much attention recently, since it has been detected in patients with hepatocarcinoma [18], in blood donors and transfused patients [19,20], and in patients infected with hepatitis C virus [21][22][23]. In chronic HCV patients on hemodialysis, the prevalence of occult HBV infection is not yet well known [22,24].…”

Section: Discussionmentioning

confidence: 99%

Occult hepatitis B virus infection in immunocompromised patients

Jardim¹,

Gonçales²,

Pereira³

et al. 2008

Braz J Infect Dis

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Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAgnegative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV positive patients was not a determining factor for occult HBV infection. In addition, no significant relationship between HBV-DNA and HCV co-infection in the HIV-positive patient group was found. A lack of significant associations was also observed between positivity for HBV-DNA and CD4 count, viral load and previous lamivudine treatment in these HIV-positive patients.

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“…Meanwhile, we need to know more about the potential progression of occult hepatitis B, as well as its transmission, carcinogenesis [19] and association with hepatitis C [20].…”

Section: Discussionmentioning

confidence: 99%

Occult B infection in the Brazilian northeastern region: a preliminary report

Almeida¹,

Tavares-Neto²,

Trépo

et al. 2008

Braz J Infect Dis

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A sentinel study on viral hepatitis is currently being carried out in the village of Cavunge in a semiarid rural region of the state of Bahia, northeastern Brazil. This study has identified individuals in whom anti-HBc IgG was the only serological marker for hepatitis B virus (HBV). This serological pattern may constitute evidence of occult HBV infection. This study Investigated the possibility of occult hepatitis B virus infection in individuals in a rural community who tested positive for anti-HBc IgG alone. A cross-sectional population-based study. ELISA III was performed on serum samples to test for serological viral markers, and ultrasensitive PCR (US-PCR) was used to assess viremia. Among the 1,536 serum samples, 3.6% (n=55) were positive for anti-HBc alone. Four years after this first serological survey, 31 of those 55 individuals (56.3%) were retested, and 11 (35.5%) remained anti-HBc positive alone. Two of these 31 (6.5%) were HBV-DNA positive based on US-PCR, with normal aminotransferase levels in both cases. Cases of occult hepatitis B infection were identified in this semiarid rural community of northeastern Brazil, where endemicity of HBV is moderate. Key-Words: Anti-HBc alone, hepatitis B virus, occult hepatitis B, ultrasensitive PCR.Approximately 400 million people worldwide are chronic hepatitis B carriers. Despite vaccination, serological tests performed in hemotherapy services, and programs for the prevention of sexually transmitted infections, the number of hepatitis B virus (HBV)-infected individuals remains high, with prevalence ranging from 0.1% to 20% [1].The serological marker most widely used to detect exposure to HBV is HBcAg IgG; however, this marker is unable to define the status of the HBV carrier [2]. In individuals in whom antibody against the core protein (anti-HBc IgG) is the only positive marker, there are various possible explanations for false-positive test results, including patients with past, resolved infection, in whom the antibody against hepatitis B surface antigen (anti-HBs) is not present, occult HBV infection due to mutation of the S gene, or very low viral replication [3]. In this last hypothesis, analysis for HBV-DNA is considered the most sensitive diagnostic method [4].Clearance of hepatitis B surface antigen (HBsAg) generally indicates seroconversion to anti-HBs and consequent remission of HBV infection [5]. However, several researchers have shown that seroconversion to anti-HBs is not necessarily indicative of virological cure. In this case, an occult, silent or latent hepatitis B infection may be characterized by presence of viral DNA alone, while the patient tests negative for HBsAg or anti-HBc [6]. A clear example is the diagnosis of this infection in patients with chronic hepatitis of undefined etiology (cryptogenic hepatitis), comorbid hepatitis C virus (HCV), HIV carriers, patients with chronic renal failure or patients with hepatocellular carcinoma [7,8]. There are also case reports of hepatitis B transmission following blood transfusion or organ donation...

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The influence of occult infection with hepatitis B virus on liver histology and response to interferon treatment in chronic hepatitis C patients

Cited by 27 publications

References 49 publications

Prevalence of Occult Hepatitis B Infection in Iranian Cancer Patients Before Chemotherapy Treatment

Prevalence of Occult Hepatitis B Infection in Iranian Cancer Patients Before Chemotherapy Treatment

Occult hepatitis B virus infection in immunocompromised patients

Occult B infection in the Brazilian northeastern region: a preliminary report

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