Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease

Abstract

Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease *Avanços e oportunidades atuais na pesquisa sobre lúpus: influências ambientais e mecanismos da doença

Emission patterns and risk assessment of polybrominated diphenyl ethers and bromophenols in water and sediments from the Beijiang River, South China

“…Bisphenol A (BPA), another environmental estrogen and an endocrine disruptor, is a synthetic chemical primarily used to produce polycarbonate plastics and epoxy resins (Cooper et al, 2008;EC, 2003;Melnick et al, 2002). Due to the diverse uses of BPA in consumer products, it has been regularly detected in a wide range of environmental matrices, including air, water, sewage sludge and sediments (Huang et al, 2012;Lee et al, 2013;Xiong et al, 2015), even human blood and tissues (Vandenberg et al, 2010;Zhang et al, 2013).…”

Incidência e aspectos clínico-laboratoriais do Lúpus eritematoso sistêmico em cidade do Sul do Brasil

“…11 Because SLE is more common in the black population, 12 other factors, such as ethnical and economic compositions, may be involved. The city of Natal has a greater percentage of mixed heritage and black individuals than the municipality of Cascavel (55.4% and 20.2%) 13 and a lower human development index (HDI).…”

Autoimmunity

“…Additionally, there is a body of literature, mostly consisting of case reports and case series, linking the onset of autoimmune diseases (such as rheumatoid arthritis and multiple sclerosis) with preceding viral or bacterial infections. The epigenetics-infection-autoimmunity link has been strengthened by the realization that certain retroviruses, including the Epstein-Barr virus, can lead to epigenetic changes in host B cells and are themselves also regulated by DNA methylation (Richardson, 2007;Cooper et al, 2008).…”