Autoimmunity

Ray, Donna; Yung, Raymond

doi:10.1002/9780470959824.ch9

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Epigenetics In Immune Diseases1

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2014

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“…There is a clear gender bias in many autoimmune diseases ( Whitacre et al, 1999 ; Ray and Yung, 2011 ; Ngo et al, 2014 ). For example, there are two to three times more women than men affected by RA and multiple sclerosis (MS).…”

Section: Epigenetics In Immune Diseasesmentioning

confidence: 99%

Potential of epigenetic therapies in non-cancerous conditions

Mau

Yung

2014

Front. Genet.

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There has been an explosion of knowledge in the epigenetics field in the past 20 years. The first epigenetic therapies have arrived in the clinic for cancer treatments. In contrast, much of the promise of epigenetic therapies for non-cancerous conditions remains in the laboratories. The current review will focus on the recent progress that has been made in understanding the pathogenic role of epigenetics in immune and inflammatory conditions, and how the knowledge may provide much needed new therapeutic targets for many autoimmune diseases. Dietary factors are increasingly recognized as potential modifiers of epigenetic marks that can influence health and diseases across generations. The current epigenomics revolution will almost certainly complement the explosion of personal genetics medicine to help guide treatment decisions and disease risk stratification.

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Section: Epigenetics In Immune Diseasesmentioning

confidence: 99%