O componente genético da determinação dos lipídeos séricos

Andrade, Fabiana Michelsen de; Hutz, Mara Helena

doi:10.1590/s1413-81232002000100016

Cited by 6 publications

(9 citation statements)

References 48 publications

(37 reference statements)

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“…A transferência de ésteres de colesterol para o LDL-C e VLDL ocorre em troca de TG (BARTER, 2002). Este fluxo do colesterol para o fígado é conhecido como transporte reverso do colesterol.…”

Section: Polimorfismos Genéticos Associados à Dislipidemiaunclassified

“…Os níveis séricos de lipídeos têm etiologia multifatorial e são determinados por um grande número de fatores ambientais e genéticos e a identificação do componente genético na causa da dislipidemia tem sido intensamente investigada nos últimos anos (ANDRADE; HUTZ, 2002). Dentre os fatores genéticos relacionados à DAC estão as variações nos loci genéticos responsáveis pela estrutura e metabolismo de lipoproteínas e do receptor de lipoproteína de baixa densidade (LDLR) que podem contribuir para o desenvolvimento da DAC.…”

Section: Introductionunclassified

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Polimorfismos genéticos associados ao metabolismo lipídico envolvidos na fisiopatologia do acidente vascular encefálico isquêmico

Flauzino

Alfieri

Kallaur

et al. 2014

Semin. Cienc. Biol. Saude

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O acidente vascular encefálico (AVE) é uma desordem complexa, multifatorial e poligênica decorrente da interação entre componentes genéticos do indivíduo e fatores ambientais. Estudos prévios têm estabelecido a hipertensão arterial, tabagismo, diabetes mellitus, dislipidemia, elevado índice de massa corpórea, distúrbios da coagulação e aumento da idade como fatores de risco preditores de AVE. A dislipidemia tem sido associada à fisiopatologia do AVE isquêmico e polimorfismos genéticos que ocorrem na via metabólica dos lipídeos têm sido propostos como fatores genéticos associados ao AVE isquêmico. O componente genético na causa da dislipidemia tem sido intensamente investigado nos últimos anos. Entre os vários polimorfismos genéticos, os que ocorrem nos genes Apo E, Apo B, LDLR, Apo A-I, Apo C-III, lipase hepática, proteína transferidora de ésteres de colesterol (CETP), lipase lipoprotéica (LPL) e proteína convertase subtilisina/kexina tipo 9 (PCSK9) têm sido objeto de estudos na população em geral. Os dados sobre o perfil lipídico e o estudo dos polimorfismos dos genes que codificam proteínas estruturais e enzimas relacionadas com o metabolismo dos lipídeos podem revelar a prevalência das dislipidemias em uma população, possibilitando uma intervenção direcionada para o controle e prevenção das doenças ateroscleróticas como o AVE isquêmico. ResumoPalavras-chave: Acidente vascular encefálico. Polimorfismo genético. Dislipidemia. Receptor de lipoproteína de baixa densidade. AbstractThe stroke is a complex, multifactorial, and polygenic disorder that results from the interaction between the individual genetic components and environmental factors. Previous studies have established hypertension, smoking, diabetes mellitus, dyslipidemia, elevated body mass index, disturbances of coagulation and increasing age as predictors of stroke risk factors. Dyslipidemia has been associated with pathophysiology of ischemic stroke and genetic polymorphisms that occur in the metabolic pathway, such as lipids metabolism, has been one of the hereditary factors related to ischemic stroke. The genetic component in the cause of dyslipidemia has been intensively investigated in recent years. Among the

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Section: Polimorfismos Genéticos Associados à Dislipidemiaunclassified

Section: Introductionunclassified

Polimorfismos genéticos associados ao metabolismo lipídico envolvidos na fisiopatologia do acidente vascular encefálico isquêmico

Flauzino

Alfieri

Kallaur

et al. 2014

Semin. Cienc. Biol. Saude

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“…According to Andrade and Hutz [1], the apo E gene exerts a strong influence on the serum levels of LDL-C.…”

Section: Genetic Polymorphisms Associated With Dyslipidemiamentioning

confidence: 99%

“…Serum lipids have a multifactorial etiology that is determined by a large number of environmental and genetic factors [ 1 ]. Genetic and dietary factors influence serum cholesterol concentration, but detailed mechanisms of their interactions are not well known.…”

Section: Introductionmentioning

confidence: 99%

The Roles of Genetic Polymorphisms and Human Immunodeficiency Virus Infection in Lipid Metabolism

Almeida

Reiche

Kallaur

et al. 2013

BioMed Research International

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Dyslipidemia has been frequently observed among individuals infected with human immunodeficiency virus type 1 (HIV-1), and factors related to HIV-1, the host, and antiretroviral therapy (ART) are involved in this phenomenon. This study reviews the roles of genetic polymorphisms, HIV-1 infection, and highly active antiretroviral therapy (HAART) in lipid metabolism. Lipid abnormalities can vary according to the HAART regimen, such as those with protease inhibitors (PIs). However, genetic factors may also be involved in dyslipidemia because not all patients receiving the same HAART regimen and with comparable demographic, virological, and immunological characteristics develop variations in the lipid profile. Polymorphisms in a large number of genes are involved in the synthesis of structural proteins, and enzymes related to lipid metabolism account for variations in the lipid profile of each individual. As some genetic polymorphisms may cause dyslipidemia, these allele variants should be investigated in HIV-1-infected patients to identify individuals with an increased risk of developing dyslipidemia during treatment with HAART, particularly during therapy with PIs. This knowledge may guide individualized treatment decisions and lead to the development of new therapeutic targets for the treatment of dyslipidemia in these patients.

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“…The physiopathology by which HAART determines HIV lipodystrophy syndrome, dyslipidemia therefore remains unknown. Second Andrade & Hutz (2002), the lipid serum levels are multifactorial characteristics, determinate by genetic and environmental factors, highlighting the genetic variability found in those genes that can affect the response to drugs used in hyperlipidemia treatment. The authors of the lipodystrophy ambulatory care are developing a research paper about a case-control study conducted from December 2009 to July 2012.…”

Section: Biochemicalmentioning

confidence: 99%

Dyslipidemia in Patients with Lipodystrophy in the Use of Antiretroviral Therapy

Libonati¹,

Dutra²,

Barbosa³

et al. 2012

Dyslipidemia - From Prevention to Treatment

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O componente genético da determinação dos lipídeos séricos

Cited by 6 publications

References 48 publications

Polimorfismos genéticos associados ao metabolismo lipídico envolvidos na fisiopatologia do acidente vascular encefálico isquêmico

Polimorfismos genéticos associados ao metabolismo lipídico envolvidos na fisiopatologia do acidente vascular encefálico isquêmico

The Roles of Genetic Polymorphisms and Human Immunodeficiency Virus Infection in Lipid Metabolism

Dyslipidemia in Patients with Lipodystrophy in the Use of Antiretroviral Therapy

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