IGF-1 minimiza os efeitos deletérios do desuso no músculo sóleo de ratos

Silva, Carlos Alberto da; Petermann, Carlos; Cancelliero, Karina Maria; Durigan, João Luíz Quagliotti; Polacow, Maria L. O.

doi:10.1590/s1413-78522011000300004

Cited by 2 publications

(1 citation statement)

References 19 publications

(24 reference statements)

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“…Therefore, hypoactivity, functional restriction or disuse also leads to reduced signaling mechanisms that are in charge of the maintenance of increase in energetic stores, which are essential to maintain posture 20,21 . Disuse is target of studies performed in several clinical conditions, such as: long bedside periods, fixation of limbs, microgravity or the use of orthosis, and these factors trigger the catabolic state of skeletal muscles 22,23 . Molecular studies performed in skeletal muscles submitted to disuse verified reduced insulin transduction signaling, thus suggesting deficit in the activation of the insulin receptor and of the enzymes activated from it, including the phosphorylation of IRS-1 (insulin receptor substrate 1), activation of P13-K, decreased population of GLUT4 transporters and implantation of the picture of resistance to insulin 24,13 .…”

Section: Discussionmentioning

confidence: 99%

Disuse induced by the spine rectification vest: experimental study

Guirro¹,

Arruda

Silva

2014

Fisioter. Pesqui.

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The spine is the main support and movement axis of the locomotor system, and numberless clinical conditions may require that this structure be submitted to functional restriction. Among the non-invasive treatments used in spinal or appendicular skeleton injuries, the immobilization of the spine is used as a rehabilitation strategy. Because of the functional restrictions generated by restraining devices used on the spine, the proposal of this study was to adapt a spinal orthosis on rats, thus mimicking the immobilization of corrective vests and assessing the energetic conditions of thoracic muscles after 12 weeks of application. Wistar rats that were 42 days old were used in this study (post-weaning period), followed-up for 12 weeks in 2 groups called control (C) and rectification vests (R), which were made of PVC to immobilize the spine. The following concentrations were evaluated: glycogen (GLY) of the paravertebral muscle and the thorax; total proteins and DNA (TP/DNA) and interleukin-6 (IL-6). The normality Kolmogorov-Smirnov test was used for statistical analysis, followed by the Tukey test. A 5% level was established for all of the calculations. It was observed that group R presented 12% less body mass and GLY stores 21% lower; the ratio between TP/DNA was in average 6.6% lower; IL-6 concentrations were in average 25% higher. The study shows that the movement restriction in the spine leads to energetic crisis and compromised muscular development. More studies should be conducted with this model to generate physical therapy strategies that could reduce muscle compromise after spine immobilization.

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Section: Discussionmentioning

confidence: 99%

Disuse induced by the spine rectification vest: experimental study

Guirro¹,

Arruda

Silva

2014

Fisioter. Pesqui.

Self Cite

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Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy

Malavaki

Sakkas

Mitrou

et al. 2015

J Muscle Res Cell Motil

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Disuse atrophy is the loss of skeletal muscle mass due to inactivity or lower than 'normal' use. It is not only a furtive component of the 'modern' sedentary lifestyle but also a part of numerous pathologies, where muscle loss is linked to disease specific and/or other toxicity factors, eventually leading to wasting (cachexia). Whether disuse-or-disease induced, muscle loss leads to weakness and metabolic comorbidities with a high societal and financial cost. This review discusses the intricate network of interacting signalling pathways including Atrogin-1/MAFbx, IGF1-Akt, myostatin, glucocorticoids, NF-kB, MAPKs and caspases that seem to regulate disuse atrophy but also share common activation patterns in other states of muscle loss such as sarcopenia or cachexia. Reactive oxygen species are also important regulators of cell signalling pathways that can accelerate proteolysis and depress protein synthesis. Exercise is an effective countermeasure and antioxidants may show some benefit. We discuss how the experimental model used can crucially affect the outcome and hence our understanding of atrophy. Timing of sampling is crucial as some signalling mechanisms reach their peak early during the atrophy process to rapidly decline thereafter, while other present high levels even weeks and months after study initiation. The importance of such differences lays in future consideration of appropriate treatment targets. Apart from attempting to correct defective genes or negate their effects, technological advances in new rational ways should aim to regulate specific gene expression at precise time points for the treatment of muscle atrophy in therapeutic protocols depending on the origin of atrophy induction.

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IGF-1 minimiza os efeitos deletérios do desuso no músculo sóleo de ratos

Cited by 2 publications

References 19 publications

Disuse induced by the spine rectification vest: experimental study

Disuse induced by the spine rectification vest: experimental study

Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy

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