Efeitos do tempo de descompressão após trauma medular na recuperação neurológica em ratos Wistar

Gaia, Leonardo Franco Pinheiro; Sattin, Alexandre Adorno; Cristante, Alexandre Fogaça; Marcon, Raphael Martus; Filho, Tarcísio Eloy Pessoa de Barros; Oliveira, Reginaldo Perilo; Rocha, Ivan Dias da; Dias, Arthur Roncon; Omori, Clarissa Harumi

doi:10.1590/s1413-78522010000600002

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…The international multicentre Surgical Timing in Acute Spinal Cord Injury Study (STASCIS), however, recommends reduction within 24 hoursthe point after which neurological recovery is highly unlikely. [8] Several other human [3,4,[9][10][11][12] and animal studies [13][14][15] similarly found that decompression in ˂12 hours is associated with better outcomes, and that delay of >24 hours may result in permanent neurological damage. The difference between 4 and 24 hours is significant, considering the practicality of performing a reduction, closed or open, within the limits of healthcare resources available in SA.…”

Section: Discussionmentioning

confidence: 99%

Closed traction reduction of cervical spine facet dislocations: Compelled by law

Potgieter

Mohideen

et al. 2019

S Afr Med J

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The urgency of closed reduction of acute low-velocity cervical facet dislocations has recently been highlighted by the Constitutional Court of South Africa (SA), following a permanent spinal cord injury that a young rugby player sustained during a club-level match. The court found that if emergency care of the complainant had resulted in rapid closed reduction of his cervical spine injury, he might not have suffered permanent neurological damage. [1] The findings of the court were based on research by Newton et al., [2] who specifically looked at the timing of reduction of low-velocity cervical facet dislocation sustained by rugby players. In their cohort, reduction of facet dislocation within 4 hours after injury was associated with improved neurological outcomes. By performing an early closed reduction of the cervical spine, pressure is relieved from the spinal cord, preventing secondary ischaemic trauma and thus improving the possibility of neurological recovery. [3-5] It is important to note that this cohort of patients sustained low-velocity injuries. These may include sports-related injuries, falls from a standing height and blunt object assault. The severity of spinal cord trauma, or the viscous response of spinal cord tissue, is a product of the severity of compression, duration of compression and rate at which compression is applied, [6] which can also be referred to as the velocity of trauma. When compression is applied at a lower velocity, the spinal cord is more likely to show recovery and can withstand higher loads of compression than when subjected to the same compressive load applied at a higher velocity. Animal studies demonstrated this threshold to be 3 m/s, which equates to a fall from a standing height. [7] The current dispensation in SA demands that injuries of this nature be treated in specialised orthopaedic or neurosurgical units, or by qualified surgeons, with limited, if any, attempts at a closed reduction prior to arrival at a dedicated unit or service. The question of feasibility of mandatory closed reduction of cervical facet dislocations within 4 hours is therefore raised. This study reviews the time delays, delaying factors and success rate of closed reductions of cervical facet dislocations in an orthopaedic department at a tertiary-level training hospital over a period of 8 years. Methods A retrospective review of case notes and imaging screens of patients >18 years of age with cervical facet-joint dislocations presenting to a tertiary-level academic hospital in Western Cape Province of SA was performed. The university-affiliated hospital has a capacity of 1 899 beds and provides advanced trauma and This open-access article is distributed under Creative Commons licence CC-BY-NC 4.0.

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Section: Discussionmentioning

confidence: 99%

Closed traction reduction of cervical spine facet dislocations: Compelled by law

Potgieter

Mohideen

et al. 2019

S Afr Med J

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The locomotor system as seen in Brazilian medical journals: a restricted collection of papers

Patel

Caramelli

Silva

2011

Revista da Associação Médica Brasileira

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This review covers recent publications on the motor system (orthopedics and movement) in Brazilian journals recently admitted to the ISI-Thomson Journal of Citations Index. Two of these are still pleading for admission into PubMed which will eventually enhance their global visibility. We offer this contribution to experts on these areas who are regular readers of Revista da Associação Médica Brasileira. Full free copies of all of them are available at www.scielo.br. The main areas covered are orthopedics of limb articulations, fractures, movement, posture, gait, exercise and animal models.

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Regenerative Treatment of Spinal Cord Injury. Literature Review. Part 1

Smirnov¹,

Грин

Крылов

2019

Nejrohirurgiâ (Mosk.)

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Treating traumatic spinal cord injuries is one of the most complicated and relevant problems in the modern medicine. In the vast majority of cases spinal cord injury (SCI) leads to persistent disability, with medical, social and economic consequences ensuing for the patient, the family and the state. Modern SCI therapy has a very limited effectiveness and does not allow to sufficiently restore the lost functions of central nervous system. Regenerative methods and particularly cell therapy are very promising to effectively treat SCI. The review highlights SCI epidemiological and pathogenetic problems, existing therapy, as well as promising methods of regenerative therapy. We emphasize the results of preclinical and clinical studies in the field of cell therapy. The review is divided into 4 parts. Part 1 describes SCI epidemiology and pathogenesis as well as its surgical, physical and pharmacological treatment.

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Efeitos do tempo de descompressão após trauma medular na recuperação neurológica em ratos Wistar

Cited by 4 publications

References 20 publications

Closed traction reduction of cervical spine facet dislocations: Compelled by law

Closed traction reduction of cervical spine facet dislocations: Compelled by law

The locomotor system as seen in Brazilian medical journals: a restricted collection of papers

Regenerative Treatment of Spinal Cord Injury. Literature Review. Part 1

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