Inhibition of carrageenan-induced expression of tissue and plasma prekallikreins mRNA by low level laser therapy in a rat paw edema model

Silva, Moisés P.; Bortone, Flávia; Silva, Marcelo P.; Araújo, Ticiana Vasques de; Costa, Maricília Silva; Júnior, José Antônio Silva

doi:10.1590/s1413-35552011005000005

Cited by 8 publications

(4 citation statements)

References 35 publications

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“…Likewise, they observed the decrease of TNF with application of PBM. Authors 42 observed that the peak of edema was established at the third hour after the induction, and observed edema reduction after 6h, corroborating the study 45 , which detected the peak of edema 4h after carrageenan injection, and the study 35 , which reported up regulation of TNF level four hours after edema induction. The studies 5,6 showed that 5.88 J of energy with visible laser inhibited edema in the hind left paw of the animals.…”

Section: Discussionsupporting

confidence: 60%

Effect of photobiomodulation therapy (660 nm and 830 nm) on carrageenan-induced edema and pain behavior in mice

Marcolino,

Hendler,

Barbosa

et al. 2022

BRJP

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BACKGROUND AND OBJECTIVES: Photobiomodulation (PBM) is an important therapeutic tool for inflammatory process modulation. In this study, the anti-inflammatory and analgesic effect of two different energies and two different wavelengths (660 nm and 830 nm) were investigate and compared through the model of carrageenan-induced paw edema in mice. METHODS: Male Swiss mice, 36 animals (n=6 animals/group) were divided into six groups: Group 1 (saline-control), Group 2 (carrageenan), Group 3 (carrageenan + laser 660 nm, 5.88 J), Group 4 (carrageenan + laser 660 nm, 2.94 J), Group 5 (carrageenan + laser 830 nm, 5.88 J), and Group 6 (carrageenan + laser 830 nm, 2.94 J). PBM was applied 1h after the carrageenan injection which induced paw edema and hyperalgesia, which were measured by means of a plethysmometer and by flicker test using a water bath at 38ºC (±0.5ºC), respectively. Left paws of mice injected with carrageenan exhibited local edema that persisted for up to 6h after its administration. All animals were evaluated before, 1, 2, 3, 4, and 6 h after the injection of carrageenan. Effect of photobiomodulation therapy (660 nm and 830 nm) on carrageenan-induced edema and pain behavior in miceEfeito da terapia por fotobiomodulação (660 nm e 830 nm) no comportamento da dor e edema induzidos por carragenina em camundongos

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Section: Discussionsupporting

confidence: 60%

Effect of photobiomodulation therapy (660 nm and 830 nm) on carrageenan-induced edema and pain behavior in mice

Marcolino,

Hendler,

Barbosa

et al. 2022

BRJP

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“…We previously showed that LLLT was effective at modulating the kinin B1 and B2 receptors mRNA expression in the subplantar muscle of rat paw carrageenan-induced inflammation [12]. In addition, using the same model, we reported that both plasma and tissue pre-kallikrein mRNA expression were modulated after LLLT [22].…”

Section: Introductionmentioning

confidence: 84%

Amelioration of Cardiac Function and Activation of Anti-Inflammatory Vasoactive Peptides Expression in the Rat Myocardium by Low Level Laser Therapy

et al. 2014

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Low-level laser therapy (LLLT) has been used as an anti-inflammatory treatment in several disease conditions, even when inflammation is a secondary consequence, such as in myocardial infarction (MI). However, the mechanism by which LLLT is able to protect the remaining myocardium remains unclear. The present study tested the hypothesis that LLLT reduces inflammation after acute MI in female rats and ameliorates cardiac function. The potential participation of the Renin-Angiotensin System (RAS) and Kallikrein-Kinin System (KKS) vasoactive peptides was also evaluated. LLLT treatment effectively reduced MI size, attenuated the systolic dysfunction after MI, and decreased the myocardial mRNA expression of interleukin-1 beta and interleukin-6 in comparison to the non-irradiated rat tissue. In addition, LLLT treatment increased protein and mRNA levels of the Mas receptor, the mRNA expression of kinin B2 receptors and the circulating levels of plasma kallikrein compared to non-treated post-MI rats. On the other hand, the kinin B1 receptor mRNA expression decreased after LLLT. No significant changes were found in the expression of vascular endothelial growth factor (VEGF) in the myocardial remote area between laser-irradiated and non-irradiated post-MI rats. Capillaries density also remained similar between these two experimental groups. The mRNA expression of the inducible nitric oxide synthase (iNOS) was increased three days after MI, however, this effect was blunted by LLLT. Moreover, endothelial NOS mRNA content increased after LLLT. Plasma nitric oxide metabolites (NOx) concentration was increased three days after MI in non-treated rats and increased even further by LLLT treatment. Our data suggest that LLLT diminishes the acute inflammation in the myocardium, reduces infarct size and attenuates left ventricle dysfunction post-MI and increases vasoactive peptides expression and nitric oxide (NO) generation.

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“…C s , T s are defined as the average swelling rate (SR) of control and the average SR of treatment. The SR and the resistant rate (RR) were then calculated using the equations below :

Swelling rate (%) = \frac{({normalA}_{normalt} - {normalB}_{normalt})}{B_{t}} \times 100 %

Resistanat rate (%) = \frac{({normalC}_{normals} - {normalT}_{normals})}{C_{s}} \times 100 %

…”

Section: Methodsmentioning

confidence: 99%

Parameters optimization of supercritical fluid‐CO2 extracts of frankincense using response surface methodology and its pharmacodynamics effects

Zhou

Qiu

et al. 2012

J of Separation Science

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The volatile oil parts of frankincense (Boswellia carterii Birdw.) were extracted with supercritical carbon dioxide under constant pressure (15, 20, or 25 MPa) and fixed temperature (40, 50, or 60°C), given time (60, 90, or 120 min) aiming at the acquisition of enriched fractions containing octyl acetate, compounds of pharmaceutical interest. A mathematical model was created by Box-Behnken design, a popular template for response surface methodology, for the extraction process. The response value was characterized by synthetical score, which comprised yields accounting for 20% and content of octyl acetate for 80%. The content of octyl acetate was determined by GC. The supercritical fluid extraction showed higher selectivity than conventional steam distillation. Supercritical fluid-CO(2) for extracting frankincense under optimum condition was of great validity, which was also successfully verified by the pharmacological experiments.

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Inhibition of carrageenan-induced expression of tissue and plasma prekallikreins mRNA by low level laser therapy in a rat paw edema model

Cited by 8 publications

References 35 publications

Effect of photobiomodulation therapy (660 nm and 830 nm) on carrageenan-induced edema and pain behavior in mice

Effect of photobiomodulation therapy (660 nm and 830 nm) on carrageenan-induced edema and pain behavior in mice

Amelioration of Cardiac Function and Activation of Anti-Inflammatory Vasoactive Peptides Expression in the Rat Myocardium by Low Level Laser Therapy

Parameters optimization of supercritical fluid‐CO2 extracts of frankincense using response surface methodology and its pharmacodynamics effects

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