Effects of treadmill-walking training with additional body load on quality of life in subjects with Parkinson's disease

Filippin, Nadiesca Taisa; Costa, Paula Hentschel Lobo da; Mattioli, Rosana

doi:10.1590/s1413-35552010005000016

Cited by 31 publications

(36 citation statements)

References 43 publications

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“…Improved motor performance, as assessed through the United Parkinson's Disease Rating Scale, was found in 60 PD patients during 16 weeks of one-on-one physical activity training or group training with nordic walking (Ebersbach et al 2010). Other studies have demonstrated that sustained exercise, such as treadmill-walking training, induces both neurogenesis and neuroregeneration as expressed through improvements in motor and non-motor functional aspects and quality-of-life in PD patients (Ang et al 2010;Filippin et al 2010;Xu et al 2010), as well the promotion of angiogenesis in brains of chronic/progressive MPTP mouse model of PD (Al-Jarrah et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Delayed Exercise-Induced Functional and Neurochemical Partial Restoration Following MPTP

Archer

Fredriksson

2011

Neurotox Res

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In two experiments, MPTP was administered to C57/BL6 mice according to a single-dose weekly regime (MPTP: 1 × 30 mg/kg on the fifth day of the week, Friday, over 4 weeks) with vehicle group (Vehicle: 1 × 5 ml/kg) treated concurrently. Exercise schedules (delayed) were introduced either at the beginning of the week after the second MPTP injection (MPTP + Exercise(2) group), or at the beginning of the week after the fourth MPTP injection (MPTP + Exercise(4) group). Wheel-running was provided on the first 4 days of each week (Monday-Thursday) more than 30-min periods. In Experiment I, wheel-running exercise was introduced either after 2 or 4 weeks after MPTP/Vehicle. MPTP and Vehicle groups not provided access to the running wheels were placed in single cages within the wheel-running room over 30-min concomitantly with the wheel-running groups. In Experiment II, wheel-running exercise was introduced 2 weeks after MPTP/Vehicle but a no-exercise control group with non-revolving wheel included (MPTP-Wheel). In both experiments, spontaneous motor activity tests during 60-min intervals were performed at the end (Fridays) of weeks 1, 2, 3, 4, 6, 8, and 10, where the week on which the first injection of MPTP was the first week; in the case of weeks 1-4, this was immediately before MPTP/Vehicle injections. It was observed that the introduction of the exercise schedule after the second MPTP injection, but not after the fourth injection, restored motor activity that had been markedly elevated by the end of the tenth week. Subthreshold administration of L-dopa tests was performed after the spontaneous motor activity tests 6, 8 and 10; these indicated significant effects of exercise, MPTP + Exercise(2) group, on Tests 6 and 8, but not Test 10. The physical exercise schedule in that group also showed markedly attenuated loss of dopamine (DA). Restoration of MPTP-induced motor activity deficits and DA loss was a function of the point at which exercise was introduced, in the present case after two administrations of the neurotoxin. In Experiment II, physical exercise markedly attenuated the hypokinesic effect of MPTP in the exercise condition, MPTP-exercise, but not in the non-exercise conditions, MPTP-Cage and MPTP-Wheel, for both spontaneous motor activity and L-dopa-induced activity. MPTP-induced loss of DA was also attenuated by exercise.

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Section: Introductionmentioning

confidence: 99%

Delayed Exercise-Induced Functional and Neurochemical Partial Restoration Following MPTP

Archer

Fredriksson

2011

Neurotox Res

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“…Investigações sobre o efeito do treinamento de marcha com carga adicional em sujeitos com Doença de Parkinson vêm mostrando bons resultados [22][23][24] . Filippin et al 22 , investigaram nove sujeitos com Doença de Parkinson, nos quais foi realizado treino de marcha com acréscimo de 10% do peso corporal.…”

Section: Resultsunclassified

“…Filippin et al 22 , investigaram nove sujeitos com Doença de Parkinson, nos quais foi realizado treino de marcha com acréscimo de 10% do peso corporal. O treino foi realizado 50 minutos por dia, três dias por semana, durante 18 semanas.…”

Section: Resultsunclassified

“…Teve como resultado melhora na qualidade de vida e diminuição da deficiência motora. O acréscimo de peso corporal no presente estudo (3,75%) foi bem inferior ao de Filippin 22 , devido ter a finalidade de aumentar a estabilidade do sujeito durante a marcha. Por outro lado, no estudo de Filippin et al 22 o peso teve a finalidade de sobrecarga de treinamento, melhora do condicionamento físico.…”

Section: Resultsunclassified

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Efeito Da Adição De Carga No Tronco Sobre a Marcha De Um Sujeito Com Ataxia

et al. 2016

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RESUMOO objetivo deste trabalho foi descrever as alterações sobre a cinemática da marcha após a adição de carga no tronco de um sujeito com ataxia. A avaliação da marcha foi realizada sem e com o uso de colete (modelo A e B). Para a obtenção dos dados referentes às variáveis estudadas foi utilizado o sistema de cinemetria VICON. Os principais resultados encontrados apontam que para a situação com o colete A houve um menor tempo de apoio simples e um maior tempo de apoio duplo em comparação a situação sem colete. Já em relação à velocidade da marcha podemos notar que a velocidade foi maior na situação com o colete B. Por outro lado, na situação sem colete o sujeito teve um comprimento de passo maior e uma largura do passo menor. Conclui-se que a adição de carga no tronco da forma utilizada neste estudo não se mostrou benéfica para a marcha. Descritores ABSTRACTThe purpose of this study was to describe the changes on gait kinematics after the load added in the trunk of subject with ataxia. The data collection was carried out in three steps, without using any vest and with the use of vests (model A and model B). To obtain data of the studied variables the VICON system was used. The main findings were that, for the situation with the vest A occurred a shorter uni foot support and a longer bipedal support, compared to the situation without a vest. In relation to gait velocity was observed that the rate was higher in the situation with the vest B. On the other hand the situation without vest, the subject had a greater step length and shorter step width. Therefore can be concluded that, adding load in the trunk as used in this study did not prove be beneficial for the gait.

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“…6). Treadmill training and other exercise regimens improve or maintain motor and nonmotor functions in Alzheimer's disease (AD), 11 Parkinson's disease (PD), 12,13 amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease), 7 and stroke. [14][15][16][17][18][19][20] Exercise also benefits cognitive function in healthy aged and young individuals, suggesting a role in maintenance of neuronal structures.…”

Section: Exercise Is Neuroprotective In Humans and Animalsmentioning

confidence: 99%