Concomitância de fibromialgia em pacientes com espondilite anquilosante

Abstract

Introduction:Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the axial skeletal system, causing pain and functional incapacity. To measure the impact of AS on patient's life, questionnaires are used to assess disease activity (BASDAI); functional incapacity (BASFI); and quality of life (ASQoL). Fibromyalgia (FM) is one of the most common causes of generalized pain and can coexist with other diseases; it can be assessed by the Fibromyalgia Impact Questionnaire (FIQ). Few studies have demonstrated correlations between FM and AS. The present study obtained data regarding the epidemiologic profile of patients with AS and FM and evaluated the prevalence of FM in patients with AS. The FM influence on BASDAI, BASFI and ASQoL test scores was assessed. Patients and Method: A total of 71 patients with AS, diagnosed according to the modified New York criteria, were studied. Clinical and functional assessment was performed and BASDAI, BASFI and ASQoL tests were applied. Patients with a diagnosis of FM were evaluated through the FIQ. Results: Eleven patients met the criteria for FM; thus a FM prevalence of 15% was observed among the patients with AS. FM was more prevalent among women (3.8:1). Age at disease onset (AS) was 27.5 years. The HLA-B27 antigen was positive in most of them (80.4%). When comparing BASDAI, BASFI and ASQoL test means, it was observed that values are significantly higher (P < 0.01) among patients with FM. We concluded that the coexistence of FM can worsen AS activity aspects, as well as functional incapacity and quality of life.

Prevalence of chronic widespread pain in a population-based cohort of patients with spondyloarthritis – a cross-sectional study

“…Previous research has found that it is important to consider that the evaluation and diagnosis of SpA, particularly in women, can be delayed [35] and complicated by the presence of CWP. Symptoms such as chronic back pain, stiffness, and fatigue are common in patients with both SpA and FM, and can be interpreted, as indicating an increase in disease activity [26, 27, 36, 37]. Also difficulties in distinguishing fibromyalgia tender points and enthesitis sites in SpA have been reported [38], with an overlap of about 30% between the inflammatory back pain (IBP) criteria and the FM criteria.…”

Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system

“…Fibromyalgia is a syndrome of unknown etiology characterized by widespread chronic pain very often associated with fatigue, anxiety, depression and sleep disorders. Its prevalence in SpA ranges from 12.5% to 15% [141][142][143] and 2-7% in the general population. 144 In axial SpA patients, fibromyalgia reaches a prevalence of 25%.…”

Qualidade De Vida De Pacientes Diagnosticados Com Espondilite Anquilosante: Uma Revisão Integrativa

“…Do total de artigos, 12 (N1, N2, N3, N6, N7, N9, N13, N14, N15, N16, N17, N19) possibilitaram a análise da população conforme o sexo, observandose maior prevalência do sexo masculino (KJEKEN et al, 2013;CONNOLLY;FITZPATRICK;O'SHEA, 2019;ALAMINO et al, 2011;LAW et al, 2018;WEBERS et al, 2016;DURCAN et al, 2012;FIGUEREDO et al, 2014;AZEVEDO et al, 2010;AZEVEDO et al, 2016;OLIVEIRA JUNIOR et al, 2015;AYDIN et al, 2015;BAE et al, 2019). Apesar de alguns dos estudos, como N13 e N16 (FIGUEREDO et al, 2014;OLIVEIRA JÚNIOR et al, 2015), N16 apontou que homens apresentam melhor status funcional que mulheres, correlacionando melhores níveis de funcionalidade (HAQ-DI) a melhores índices de qualidade de vida e de atividade da doença (BASDAI e CDAI) (OLIVEIRA JÚNIOR et al, 2015).…”

“…trabalho, relatando uma piora no rendimento empregatício, sendo as áreas da concentração, carga horária de trabalho e afazeres domésticos as principais afetadas (CONNOLLY;FITZPATRICK;O'SHEA, 2019. O'SHEA, ) al., 2018WEBERS et al, 2016;DURCAN et al, 2012;AYDIN et al, 2015;YEN et al, 2017;AZEVEDO et al, 2010;BAE et al, 2019;PARK et al, 2019;VISHA et al, 2019;REINDERS;VAN WYK, 2012).Fonte: Elaborado pelos autores.…”