Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system

Abstract

Tumor necrosis factor alpha (TNF-α) and interleukin-17 (IL-17) are two pro-inflammatory cytokines involved in the pathophysiology of spondyloarthritis (SpA). Therapies targeting TNF-α or IL-17 are used as a second line among SpA patients failing non-steroidal anti-inflammatory drugs. The choice of such treatment has to take into account the patient’s comorbidities. Neurologic diseases are common and their association with SpA deserves to be studied. Therefore, the role of TNF-α and IL-17 cytokines is worth investigating in these neuropsychiatric diseases. This review aimed to explore the role of TNF-α and IL-17 in the pathogenesis of uveitis, multiple sclerosis, neuromyelitis optica, Alzheimer’s disease, Parkinson’s disease and depression. This update is critical to guide the therapeutic management of these co-morbidities in SpA patients.

Bone metabolism and inflammatory biomarkers in radiographic and non-radiographic axial spondyloarthritis patients: a comprehensive evaluation

“…The underlying pathophysiology of axSpA is thought to be driven by inflammation, which results in systemic and local bone loss and local new bone formation ( 33 ). Inflammation in this pathology is mediated by pro-inflammatory cytokines, such as IL6, TNF-α, and IL17 ( 34 , 35 ).…”

Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea

“…In this study, we found that MLT inhibited the activation of the NF-κB pathway in TNF-α-induced inflammatory HaCaT cell, and MLT remarkably decreased the expression of NF-κB downstream genes, IL-1α and IL-1β , in LL37- or TNF-α-treated HaCaT cells. Moreover, TNF-α and IL-17A were also reported as the key cytokines in AD and rosacea ( 32 , 64 , 65 ). Here, we also noted the repression of MLT on IL-17A/TNF-α in rosacea-like mice.…”

The mosaic of autoimmunity – Finally discussing in person. The 13th international congress on autoimmunity 2022 (AUTO13) Athens

“…The authors concluded that serum cytokine measurements can be employed as indicators of the severity of illness. Actually, cytokines such as IL-8, IL-17, and TNF- α have been shown to serve as biomarkers alongside variuos implications in other diseases [ [40] , [41] , [42] ].…”