Manifestação otológica localizada em paciente com granulomatose de Wegener

Sensorineural hearing loss as the first manifestation of Sjögren's syndrome

“…Vestibular symptoms may be present. 3,5,6 SNHL can be the initial manifestation of a systemic autoimmune disease such as SS, systemic lupus erythematosus, granulomatosis with polyangiitis (Wegener's), 7 polyarteritis nodosa, rheumatoid arthritis, and Cogan's syndrome. 8,9 There is a significant association between thyroid autoimmunity and Ménière's disease, which can itself be very difficult to distinguish from AIED in the first months, 10 but our patient had no vestibular symptoms.…”

Wegener Granulomatosis: Otologic Manifestation as First Symptom

“…WG is a rare idiopathic disease, immunologically mediated, which affects the small arteries of the upper and lower respiratory tracts and the kidneys, causing inflammation with necrosis, granuloma formation, and vasculitis in these organs. 1 2 3 4 The average age of diagnosis is usually between 20 and 40 years, and males are affected more than females (1.5:1.0). 5 Otologic manifestation varies widely, occurring in ∼20 to 60% of the affected patients, and includes serous otitis media, chronic otitis media, sensorineural hearing loss, vertigo, tinnitus, and facial palsy.…”

“…Wegener granulomatosis (WG) is a rare multisystem autoimmune disease of unknown etiology. 1 2 It is a systemic vasculitis, affecting small and medium-sized vessels of the upper and lower respiratory tract and kidneys, including necrotizing granulomatous inflammation. 2 3 WG has a spectrum of clinical presentations that includes recurrent respiratory infection, renal manifestations, and nonspecific systemic symptoms.…”

“…1 2 It is a systemic vasculitis, affecting small and medium-sized vessels of the upper and lower respiratory tract and kidneys, including necrotizing granulomatous inflammation. 2 3 WG has a spectrum of clinical presentations that includes recurrent respiratory infection, renal manifestations, and nonspecific systemic symptoms. Otologic manifestations are occasionally the first to appear in 20 to 60% of cases of WG, and serous otitis media is the most common presentation in ear disease.…”