Thyroid abnormalities in systemic lupus erythematosus: a study in 100 Brazilian patients

Kakehasi, Adriana María; Dias, Vinícius Naves; Duarte, Juliana Elias; Lanna, Cristina Costa Duarte; Carvalho, Marcos Alberto de

doi:10.1590/s0482-50042006000600003

Cited by 13 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…32,33 We did not find any association either with activity or with the cumulative harm index. However, the disease activity of our SLE patients was quite low, with median SLEDAI of zero.…”

Section: Discussioncontrasting

confidence: 57%

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

et al. 2017

View full text Add to dashboard Cite

BACKGROUND: Thyroid autoimmunity is more common in patients with rheumatic diseases than in healthy populations. The degree of association seems subject to influence from patients' geographical location. Here, we aimed to ascertain the prevalence of thyroid autoantibodies in a cohort of patients with systemic rheumatic disease and the degree of association between its presence and inflammatory activity. DESIGN AND SETTING: Cross-sectional observational study in a rheumatology unit. METHODS: 301 patients with systemic lupus erythematosus (SLE), 210 with rheumatoid arthritis (RA), 58 with scleroderma (SSc) and 80 with spondyloarthritis (SpA) were studied regarding thyroid function (TSH and T4), anti-thyroglobulin (TgAb) and anti-thyroperoxidase (TPOab) and compared with 141 healthy controls. Disease activity in patients with rheumatic disease was assessed through appropriate indexes. RESULTS: There were more antithyroid antibodies in SLE patients with hypothyroidism (P = 0.01; odds ratio, OR 2.7; 95% confidence interval, CI: 1.20-6.26) and in those without hypothyroidism (P = 0.06; OR 2.4; 95% CI: 1.28-4.55) than in controls. SSc patients also showed P = 0.03 both with antithyroid antibodies and hypothyroidism (OR 3.4; 95% CI: 1.06-10.80) and without hypothyroidism (OR 3.1; 95% CI: 1.11-0.13). RA and SpA patients had the same prevalence as controls (P not significant). Presence of autoantibodies with and without hypothyroidism was not associated with the activity or functional indexes evaluated. CONCLUSION: SLE and SSc were associated with higher prevalence of thyroid autoantibodies in patients with and without hypothyroidism, unlike SpA and RA. There was no link between thyroid autoantibody presence and disease activity or functional impairment.

show abstract

“…32,33 We did not find any association either with activity or with the cumulative harm index. However, the disease activity of our SLE patients was quite low, with median SLEDAI of zero.…”

Section: Discussioncontrasting

confidence: 57%

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This is the group which have a non-specific thyroid dysfunction, requiring treatment for the underlying disease but not for the thyroid abnormality. However, the study by Park et al [7], which used the European Consensus Lupus Activity Measurement (ECLAM), and study by Adriana [9] using SLEDAI failed to show any significant relation between thyroid dysfunction and lupus disease activity, possibly because of absence of such non-specific thyroid derangement in their lupus cohort.…”

Section: Discussionmentioning

confidence: 93%

“…Thyroid being one of the common target of autoimmune process, its association with SLE, a systemic autoimmune disease is likely. Autoimmune thyroid disease, marked by the presence of antibodies directed against thyroid antigens, has been associated with a number of non-organ-specific rheumatologic disorders like systemic lupus erythematosus [5][6][7][8][9][10], Sjögren's syndrome [12], rheumatoid arthritis [10] and giant cell arteritis [13].…”

Section: Introductionmentioning

confidence: 99%

The spectrum of thyroid disorders in systemic lupus erythematosus

Kumar

Kole²,

Karmakar

et al. 2010

Rheumatol Int

View full text Add to dashboard Cite

To study the spectrum of thyroid disorders in systemic lupus erythematosus (SLE). Hundred SLE patients as per American Rheumatology Association(ARA) classification criteria underwent clinical examination, including assessment of disease activity (SLEDAI) and laboratory evaluation for serum triiodothyronine (T3),free thyroxine (FT4), thyroid stimulating hormone (TSH), antithyroperoxidase (TPO) antibody and antithyroglobulin (TG) antibody. Hundred age- and sex-matched apparently healthy individuals served as control. Thirty-six (36%) lupus patients had thyroid dysfunction when compared to 8 (8%) of controls and all of them were women. Primary hypothyroidism was the commonest dysfunction in 14 (14%), while subclinical hypothyroidism and subclinical hyperthyroidism was seen in 12 (12%) and 2 (2%), respectively. Eight (8%) had isolated low T3 consistent with sick euthyroid syndrome. Eighteen (50%) of thyroid dysfunction were autoimmune in nature (autoantibody positive) and rest 18 (50%) were non-autoimmune. Euthyroid state with the elevation of antibodies alone was seen in 12 (12%) of the lupus patients. In contrast, only 5 (5%) of controls had primary hypothyroidism and 3 (3%) had subclinical hypothyroidism, while none had hyperthyroidism. SLEDAI score and disease duration were compared between lupus patients with thyroid dysfunction to those with normal thyroid function. A statistically significant association was found between SLEDAI and thyroid dysfunction of sick euthyroid type.SLE disease duration had no statistically significant association with thyroid dysfunction. Prevalence of thyroid autoantibodies in lupus patients was 30% when compared to 10% of controls. Ninety-six (96%) of the SLE patients were ANA positive, while 4 (4%) of them were ANA negative but were anti-Sm antibody positive. There were no suggestions of any other autoimmune endocrine diseases like diabetes or Addison's disease (clinically and on baseline investigations) in our lupus cohort and hence no further work up was done for these diseases. Thyroid disorders are frequent in SLE and are multifactorial with a definite higher prevalence of hypothyroidism as well as thyroid autoantibodies.

show abstract

“…We found no difference in lupus disease activity measures (SLEDAI and PGA scores) by PA which is consistent with previous reports of AITD in lupus patients. 7–10 In a cohort of 1463 children with lupus, Setoue et al. 6 described patients with symptomatic PA (including APS 2.8% and SS 0.07%) at the time of lupus diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…4–6 Studies describing the association of PA with severe lupus primarily focused on disease activity and/or damage and overlooked patient’s quality of life as an important outcome domain. 2,3,6–10 Although PA in pediatric lupus population is described, few studies have addressed its relation to lupus outcomes. 3,6,10…”

Section: Introductionmentioning

confidence: 99%

Autoimmune thyroid diseases, autoimmune hepatitis, celiac disease and type 1 diabetes mellitus in pediatric systemic lupus erythematosus: Results from the CARRA Legacy Registry

AlAhmed

Sivaraman

Moore‐Clingenpeel

et al. 2020

Lupus

View full text Add to dashboard Cite

Objective Polyautoimmunity (PA) with systemic lupus erythematosus (SLE) is reported as a poor prognostic factor, but little is known about its effect in childhood-onset SLE (cSLE). We describe PA in cSLE within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry and evaluate its association to lupus disease outcomes. Methods CARRA Legacy Registry is the largest pediatric rheumatology registry that collected data at enrollment and every 6 months thereafter. We describe the co-occurrence of selected autoimmune disorders (autoimmune thyroid diseases, autoimmune hepatitis, celiac disease and type 1 diabetes mellitus) in cSLE. To assess outcomes, we studied measures of lupus disease activity, complications, and patient’s quality of life (QoL). Comparisons by PA status were made using chi-square, Fisher’s exact test, two-sample t-tests, Wilcoxon rank sum tests, and mixed effects models as appropriate. Results 1285 patients met the American College of Rheumatology criteria for SLE. Of those, 388 (30%) had data on comorbidity. The prevalence of PA was 8.8%. Patients with PA reported more hospitalizations and aggressive immunotherapy use. SLEDAI and PGA scores improved over time, but did not differ by PA status. No significant differences were found in QoL measures or their trajectory over time by PA status. Conclusion In cSLE, PA is associated with more hospitalizations and aggressive immunotherapy use. Although lupus disease activity improved over time, patients' QoL neither improved over time nor differed by having other autoimmune disease. Prospective, case-control, long-term follow-up studies on cSLE are needed to validate our results. MeSH Key Indexing Terms Pediatric systemic lupus erythematosus; Autoimmune diseases; Outcome assessment

show abstract

Thyroid abnormalities in systemic lupus erythematosus: a study in 100 Brazilian patients

Cited by 13 publications

References 19 publications

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

The spectrum of thyroid disorders in systemic lupus erythematosus

Autoimmune thyroid diseases, autoimmune hepatitis, celiac disease and type 1 diabetes mellitus in pediatric systemic lupus erythematosus: Results from the CARRA Legacy Registry

Contact Info

Product

Resources

About