Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

Posselt, Rayana Taques; Coelho, Vinícius N.; Pigozzo, Danieli Cristina; Guerrer, Marcela Idalia; Fagundes, Marília Da Cruz; Nisihara, Renato; Skare, Thelma Larocca

doi:10.1590/1516-3180.2017.0089110617

Cited by 13 publications

(21 citation statements)

References 43 publications

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“…In the present study, while the anti-microsomal antibody positivity rate in MS patients was found to be 11.6%, the antithyroglobulin antibody frequency was detected to be 13.6%, and none of the patients had hypothyroidism. In a study performed by Posselt et al, it was found out that the rate of antithyroglobulin antibody positivity was 4.9% without hypothyroidism in healthy controls, that this rate was much higher in patients with rheumatic disease, and that the highest rate was observed in SLE patients (16). Based on the data of our study, it can be said that the positivity of thyroid autoantibodies is higher compared to the normal population in MS disease like in the other autoimmune diseases.…”

Section: Discussionsupporting

confidence: 58%

Evaluation of autoantibody positive in multiple sclerosis patients

Gökçe¹,

Çiğdem²

2019

Cumhuriyet Medical Journal

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Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system in which impaired immune activation is involved. It is known that other autoimmune diseases are seen more frequently in MS patients. Many rheumatologic diseases could cause neurologic disorders that mimic MS. Our aim in this study is to determine the rates of autoantibody positivity and the clinical significance of these positivity rates in patients with MS. Method: 110 patients who were followed up with MS diagnosis in our clinic between 2008 and 2018 were retrospectively evaluated for autoimmune disease biomarkers. The diagnosis of MS was confirmed using both 2005 and 2010 Revised Mc Donald Criteria. Results: The ANA (antinuclear antibody) positivity rate in our patients was 10.9%, the ANA profile positivity was 9.1%. Anti-ds DNA (double stranded deoxyribonucleic acid) positivity rate was 1.8%, anti-cardiolipin Ig (immunglobulin) G and Ig M were 0.9% positive. Anti-microsomal antibody positivity was 11.8% while antithyroglobulin antibody was positively 13.6%. The value of complement 3 (C3) was found to be 92.7% normal and 4.5% higher and 2.7% lower, respectively. The C4 values were 98.2% normal, while they were 11.8% higher than normal. Six patients had six different diseases in which ethiopathogenesis the role of autoimmunity was also revealed (ankylosing spondylitis, psoriasis, systemic lupus erythematosus, morfea, ptriyazis, Sjögren's syndrome). Conclusions: Although some autoantibody positivities in MS patients are more frequent than healthy controls, these positivities are not usually associated with systemic rheumatologic disease and haven't clinical significance. Therefore, the evaluation of autoantibodies in each MS patient does not seem cost effective. So, the MS patients whose autoantibody levels are to be measured should be well selected before the evaluation the patients' medical history and complaints should be taken into consideration.

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Section: Discussionsupporting

confidence: 58%

Evaluation of autoantibody positive in multiple sclerosis patients

Gökçe¹,

Çiğdem²

2019

Cumhuriyet Medical Journal

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“…This condition has been reported rarely among studies of thyroid dysfunctions in SLE patients. [2][3][4][5][6][7][8][9] The 9% prevalence of isolated hypothyroxinemia in the SLE patients in this study was comparable to 8% in pregnant Thai women; 21 this prevalence was much higher than the 0%-1% among those previously reported. 6,22 Reasons for this high prevalence in the SLE patients in this study was not explained clearly.…”

Section: Discussionmentioning

confidence: 58%

“…Several case-controlled studies have been performed between SLE patients and healthy controls (HCs) to determine the prevalence of thyroid dysfunctions and thyroid autoantibodies. [2][3][4][5][6][7][8][9] Although a majority of these studies found the prevalence of thyroid dysfunctions, particularly hypothyroidism, to be higher in SLE patients than HCs, as confirmed by recent meta-analysis, 10 the prevalence of thyroid autoantibodies between these two groups has had conflicting results. Unfortunately, few studies have mentioned that patients with obvious thyroid disease were excluded from their study.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of thyroid dysfunctions and thyroid autoantibodies in Thai patients with systemic lupus erythematosus: An age‐ and sex‐matched controlled study

Na‐Nan,

Waisayanand,

Gumtorntip

et al. 2024

Int J of Rheum Dis

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Background/ObjectiveTo determine the prevalence of thyroid dysfunctions and thyroid autoantibodies in Thai systemic lupus erythematosus (SLE) patients, and compare them with age‐ and sex‐matched healthy controls (HCs). Associations between thyroid dysfunctions and SLE disease activity, and associated factors for thyroid dysfunctions in SLE also were determined.MethodOne hundred SLE patients, without apparent clinical thyroid disease, attended the Rheumatology Clinic between November 2021 and October 2022, were enrolled into this study. HCs were matched to SLE cases by age and sex (ratio of 1:1). Clinical manifestations, SLE disease activity and medication received were collected in all SLE patients. Thyroid function tests and thyroid autoantibodies (anti‐thyroglobulin: anti‐TG and anti‐thyroid peroxidase: anti‐TPO) were collected from all participants.ResultsWhen compared with HCs, SLE patients had higher prevalence of thyroid dysfunctions, hypothyroidism and euthyroid sick syndrome (28% vs. 7%, p < .001, and 12% vs. 2%, p = .010, and 6% vs. 0%, p = .013, respectively). Prevalence of isolated hypothyroxinemia was higher numerically in SLE patients (9% vs. 3%, p = .074). Prevalence of anti‐TG or anti‐TPO was no different between SLE patients and HCs (16% vs. 18%, p = .707). There was no association between SLE disease activity and abnormal thyroid functions or thyroid autoantibodies. Family history of thyroid disease and prednisolone use (>10 mg/day) were associated factors for thyroid abnormalities with adjusted OR (95% CI) of 6.13 (1.58–23.75), p = .009 and 4.00 (1.37–11.70), p = .011, respectively.ConclusionThyroid dysfunctions were more prevalent in SLE patients. Family history of thyroid disease and prednisolone use (>10 mg/day) were independent associated factors of thyroid abnormalities.

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“…Patient with SLE are more prone to thyroid problems compared to the controls and is usually more so in those having overlap syndrome [4,5]. They can have positive thyroid antibodies with or without overt thyroid manifestations [6]. it predominantly manifests in patients with SLE and Hashimoto's during the hypothyroid state rather than hyperthyroid, suggesting that the initial hyperthyroid state could be obscured [7].…”

Section: Discussionmentioning

confidence: 99%

Association of Autoimmune Hashimoto's Thyroiditis with Systemic Lupus Erythematosis

Kammari

Daggubati²,

Konala

et al. 2020

Cureus

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SLE (systemic lupus erythematosus) can be associated with other autoimmune disorders with overlapping clinical symptoms. We present a case of a 22-year-old male with recurring exertional dyspnea, chest pain, dry cough and chills, which on further testing revealed large pericardial effusion and bilateral pleural effusions along with laboratory abnormalities consistent with a diagnosis of overlap of SLE with serositis and Hashimoto's thyroiditis. SLE patients with underlying hypothyroidism are slow to respond to standard therapy unless the underlying hypothyroidism is adequately treated.

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Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study

Cited by 13 publications

References 43 publications

Evaluation of autoantibody positive in multiple sclerosis patients

Evaluation of autoantibody positive in multiple sclerosis patients

Prevalence of thyroid dysfunctions and thyroid autoantibodies in Thai patients with systemic lupus erythematosus: An age‐ and sex‐matched controlled study

Association of Autoimmune Hashimoto's Thyroiditis with Systemic Lupus Erythematosis

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