Corymbiform nodular amyloidosis

Abstract

Amyloidosis is part of a group of deposition diseases. Nodular amyloidosis is a rare form of primary cutaneous amyloidosis. It affects men and women, usually over the age of 60 years. Presenting manifestation of the disease are yellowish-erythematous or brownish nodules or plaques in single or multiple infiltrates. Systemic evaluation should be performed to rule out involvement of other organs. Follow-up of the patient is important because the condition may progress to systemic amyloidosis. We report a case of nodular amyloidosis in which the lesion had a corymbiform aspect without systemic involvement and no recurrence after two years of follow-up. Keywords: Amyloid; Amyloidosis; Congo red Resumo: As amiloidoses constituem um grupo de doenças de depósito. A amiloidose nodular é uma forma rara de amiloidose cutânea primária. Acomete homens e mulheres, geralmente acima de 60 anos. Apresenta-se com nódulos ou placas eritemato-amareladas ou acastanhadas infiltradas isoladas ou múl-tiplas. A avaliação sistêmica deve ser feita para descartar comprometimento de outros órgãos. É importante o seguimento devido a possibilidade de evolução para amiloidose sistêmica. Relatamos um caso de amiloidose nodular com lesão de aspecto corimbiforme sem sistematização e sem recidiva após dois anos de seguimento.

Immunohistochemical study of immunoglobulin light chains and inflammatory cells in a patient with localized primary cutaneous nodular amyloidosis

“…5 Approximately 75% of plasma cells expressed kappa chains, while the remainings expressed lambda chains. 6 However, in line with the previous study, 7 we observed no immunoreactivity of the plasma cells for both light chains, which may rule out a focal plasmacytoma. On the other hand, the perivascular and periadnexal infiltrate was mainly composed of T lymphocytes (CD3) and scarcely B lymphocytes (CD20), along with helper T lymphocytes (CD4) surpassing cytotoxic T lymphocytes (CD8).…”

“…10 However, the immunohistochemical results of amyloid deposits for lambda and kappa light chains are variable. [2][3][4][5][6][7][8][9] Our observation demonstrated that the amorphous material was strongly positive for kappa chains and weakly positive for lambda chains, indicating that the amyloid deposits may stem from polyclonal plasma cells.…”

“…[1][2][3] Immunohistochemical studies demonstrate disparate results of the amyloid deposits and plasmocytes for immunoglobulin kappa and lambda light chains. [3][4][5][6][7][8][9] We report a case of localized PCNA on the nose treated by excision and flap reconstruction.…”

Cutaneous Nodular Amyloidosis: An Unusual Penis Localization: Case Report

“…Therefore, these patients should be followed up for systemic evaluation. 1,6 Our patient did not have any symptoms and signs of systemic amyloidosis. He is still on our follow up for a possible development of systemic amyloidosis and plasma cell dyscrasia.…”

“…1,2,6 Localized amyloidosis of penis is a rare entity. There are less than 50 cases related to urethra and nine cases of glans penis in the literature.…”