Topical estradiol does not interfere with the expression of the metalloproteinase-1 enzyme in photo exposed skin cells

Neder, Luciana; Medeiros, Sebastião Freitas de

doi:10.1590/s0365-05962012000100008

Cited by 9 publications

(1 citation statement)

References 21 publications

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“…All clinical studies reporting the results of using either a topical estrogen (Table 1; Ashcroft et al, 1999, Bolognia et al, 1989, Brincat et al, 1987, Brincat et al, 1987, Callens, 1996, Castelo-Branco et al, 1992, Creidi et al, 1994, Fuchs et al, 2003, Jemec and Serup, 1989, Masuda et al, 2013, Neder and Medeiros, 2012, Patriarca et al, 2007, Patriarca et al, 2013, Piérard-Franchimont et al, 1995, Punnonen et al, 1987, Rittié et al, 2008, Sator et al, 2001, Schmidt et al, 1994, Schmidt et al, 1996, Silva et al, 2017, Son et al, 2005, Sumino et al, 2009, Varila et al, 1995) or topical isoflavone (Table 2; Bayerl and Keil, 2002, Moraes et al, 2009, Patriarca et al, 2013, Silva et al, 2017) product on the skin of menopausal or postmenopausal women were included. The area of the skin receiving the topical treatment varied among the studies, including the face, abdomen, buttocks, forearms, and thighs.…”

Section: Resultsmentioning

confidence: 99%

Estrogen-deficient skin: The role of topical therapy

Rzepecki

Murase

Juran

et al. 2019

International Journal of Women's Dermatology

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Menopause is a major turning point in a woman’s life that is characterized by declining ovarian function and decreased serum estrogen levels. The resulting hormonal changes particularly affect the skin, with postmenopausal symptoms such as loss of structural architecture and increased propensity to damage becoming rapidly noticeable. Interestingly, studies have shown that estrogen deprivation in postmenopausal conditions accelerates many skin changes, including dryness, atrophy, fine wrinkling, and poor wound healing. Thus, the effects of low estrogen on the skin are an important endogenous cause of aging skin in women, yet topical treatment strategies that target cutaneous symptoms are limited. The goal of this article is to provide an overview of the role of estrogen in the skin and changes associated with estrogen deficiency, as well as review alternatives to systemic estrogen therapy and describe the effects of these interventions on cutaneous aging in postmenopausal skin. Specifically, clinical studies that utilize topical estrogens and topical isoflavones, which are soy-derived compounds that interact with estrogen receptors, are discussed.

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