Mixofibrossarcoma: relato de caso

Abstract

Myxofibrosarcoma, previously known as malignant fibrous histiocytoma, myxoid variant, is a rare tumor of mesenchymal origin, composed of spindle cells and myxoid stroma. It mainly affects elderly people, involving the lower extremities and frequently extending to the dermis and subcutaneous tissue. The tumor presents high rates of recurrence, and a deep biopsy is required to obtain the correct diagnosis. We report a case of high-grade mixofibrossarcoma characterized by a rapidly growing tumor and the presence of marked cellular pleomorphism and an abundant myxoid matrix. Keywords: Fibrosarcoma; Histiocytoma, malignant fibrous; Neoplasms; Skin neoplasms Resumo: O mixofibrossarcoma, previamente conhecido como histiocitoma fibroso maligno, variante mixoide, é um tumor raro, de origem mesenquimal, composto por células fusiformes e estroma mixoide. Acomete mais idosos, envolvendo extremidades inferiores e estendendo-se, em sua maior parte, até a derme e o subcutâneo. Apresenta altas taxas de recorrência e para seu diagnóstico é fundamental a realização de uma biópsia profunda. Relataremos o caso de um mixofibrossarcoma de alto grau, caracterizado por lesão tumoral de crescimento rápido e pela presença de marcado pleomorfismo celular e componente mixoide em abundância.

Myxofibrosarcoma - Case report

“…This peculiar characteristic makes it very important to represent the lesion adequately for histopathological examination. 2 , 6 …”

Undifferentiated Pleomorphic Sarcoma

“…2 Undifferentiated pleomorphic sarcoma is a tumor whose histogenesis is not yet clearly defined. 1 We describe a case of undif- dermatofibrosarcoma protuberans, atypical fibroxanthoma, and leiomyosarcoma. 2 The extremities are the most common sites of involvement, especially the lower limbs.…”

Undifferentiated Pleomorphic Sarcoma

“…2 Undifferentiated pleomorphic sarcoma is a tumor whose histogenesis is not yet clearly defined. 1 We describe a case of undifferentiated pleomorphic sarcoma with cutaneous presentation and review some aspects of the disease, describing the main differential diagnoses and the clinical and histopathological findings of this rare tumor in its exuberant form, based on the current literature. We report the case of a 74-year-old male patient who sought treatment due to a rapid-onset skin lesion in the thoracic region after two months of Methotrexate is generally administered once weekly to patients, with doses ranging from 7.5 to 25 mg/week.…”