Hiperqueratose lenticular persistente

Filho, Roberto Rheingantz da Cunha; Almeida, Hiram Larangeira de

doi:10.1590/s0365-05962011000700019

Cited by 6 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested that the 5‐FU provokes a strong inflammatory response, leading to the sloughing of the HLP lesion 12,28,35 . However, some works reported a relapse after stopping the therapy 20,36 Topical or systemic retinoids: topical retinoids have not been effective, showing only a slight reduction in roughness 19,20 .…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…Ablative treatment (local excision, CO2 laser, curettage, dermabrasion, cryotherapy, and electrocoagulation): these treatments seem to be the most effective because the procedures remove the defective keratinocytes. The absence of recurrence in biopsied areas may prove the efficacy of ablative treatments 36 . However, a large number of lesions, as well as lesion location, makes this an impractical approach.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…12,28,35 However, some works reported a relapse after stopping the therapy. 20,36 4 Topical or systemic retinoids: topical retinoids have not been effective, showing only a slight reduction in roughness. 19,20 A maintenance dose applied twice weekly seems to be effective.…”

Section: Casementioning

confidence: 99%

“…The absence of recurrence in biopsied areas may prove the efficacy of ablative treatments. 36 However, a large number of lesions, as well as lesion location, makes this an impractical approach.…”

Section: Casementioning

confidence: 99%

See 3 more Smart Citations

Hyperkeratosis lenticularis perstans (Flegel’s disease): our experience and review of the literature

et al. 2020

View full text Add to dashboard Cite

Hyperkeratosis lenticularis perstans (HLP), or Flegel's disease (FD), is a rare disorder of keratinization first described in 1958 by Flegel. HLP is characterized by asymptomatic small papules distributed symmetrically on the dorsal feet and lower part of the legs. It typically presents in the fourth or fifth decade of life. FD has been reported more commonly in women, and little is known about the pathogenesis of this rare dermatosis. Histological examination is mandatory to confirm the diagnosis, and the characteristic features are: focal compact hyperkeratosis, thinned stratum malpighii, epidermal atrophy, and a dense, band-like lymphocytic infiltrate in the papillary dermis. The treatment of FD is challenging, and a fully effective standard therapy does not exist. We report four cases of HLP that have been diagnosed at the Dermatology Unit of IRCCS Ca' Granda Ospedale Maggiore Policlinico in Milan, Italy, and a literature review is enclosed.

show abstract

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Section: Casementioning

confidence: 99%

Section: Casementioning

confidence: 99%

See 2 more Smart Citations

Hyperkeratosis lenticularis perstans (Flegel’s disease): our experience and review of the literature

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It may also be hereditary, with an autosomal dominant transmission. Histologically, the condition is characterized by hyperkeratosis, a thinning or absence of the granular layer, epidermal atrophy, and a band-like infiltrate in the upper dermis [ 42 ]. Waxy keratosis of childhood presents as well-demarcated keratotic papules secondary to abnormal keratinization.…”

Section: Unclassified Disordersmentioning

confidence: 99%

New Described Dermatological Disorders

Gönül

Cemil

Keseroglu

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Many advances in dermatology have been made in recent years. In the present review article, newly described disorders from the last six years are presented in detail. We divided these reports into different sections, including syndromes, autoinflammatory diseases, tumors, and unclassified disease. Syndromes included are “circumferential skin creases Kunze type” and “unusual type of pachyonychia congenita or a new syndrome”; autoinflammatory diseases include “chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome,” “pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH) syndrome,” and “pyogenic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PAPASH) syndrome”; tumors include “acquired reactive digital fibroma,” “onychocytic matricoma and onychocytic carcinoma,” “infundibulocystic nail bed squamous cell carcinoma,” and “acral histiocytic nodules”; unclassified disorders include “saurian papulosis,” “symmetrical acrokeratoderma,” “confetti-like macular atrophy,” and “skin spicules,” “erythema papulosa semicircularis recidivans.”

show abstract

Acquired Disorders of Epidermal Keratinization

Chu

Teixeira

2016

Rook's Textbook of Dermatology, Ninth Edition

View full text Add to dashboard Cite

Acquired disorders of keratinization are a heterogeneous group of diseases, clinically characterized by dyskeratosis. This may involve a spectrum of presentations ranging from the soft velvety changes of acanthosis nigricans to the hard dry scaling of Flegel disease or the porokeratoses. The symptoms are often discrete, and while many of the diseases are poorly described, some show an association with other diseases, indicating the need for additional clinical investigations, e.g. the association between phrynoderma and malnutrition or porokeratosis and cancer. Because of the rarity of many of these disorders, treatment recommendations are frequently based purely on small observational studies: commonly advocated treatments include emollients, vitamin D derivatives or retinoids. The aetiopathogenesis of most of these disorders remains unexplored.

show abstract

Hiperqueratose lenticular persistente

Cited by 6 publications

References 9 publications

Hyperkeratosis lenticularis perstans (Flegel’s disease): our experience and review of the literature

Hyperkeratosis lenticularis perstans (Flegel’s disease): our experience and review of the literature

New Described Dermatological Disorders

Acquired Disorders of Epidermal Keratinization

Contact Info

Product

Resources

About