Acne fulminans incapacitante

Zanelato, Tiago Pina; Gontijo, Gabriela Maria Abreu; Alves, Célia Antônia Xavier de Moares; Pinto, Jacqueline Campoi Calvo Lopes; Cunha, Paulo Rowilson

doi:10.1590/s0365-05962011000700001

Cited by 14 publications

(8 citation statements)

References 13 publications

(13 reference statements)

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“…It predominates in men between 13 and 22 years of age and is characterized by abscesses, crusted hemorrhagic ulcerative lesions and purulent areas that invariably involve the trunk with less intense facial involvement, associated with sudden systemic manifestations like high fever, weight loss, asthenia, adenopathies and osteoarticular involvement that affects mainly big articulations. 4,5 Clinically, it differs from grade IV or conglobata acne, for even of the latter presents nodule-cystical eruptive lesions, there is no systemic symptomatology. Laboratory exams show that with acne fulminans there is evident leucocytosis, with left deviation and increased erythrocyte sedimentation speed.…”

Section: Discussionmentioning

confidence: 99%

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Sacroiliitis after use of oral isotretinoin - association with acne fulminans or adverse effect?

Geller¹,

Alagia²

2013

An. Bras. Dermatol.

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Acne fulminans is a rare and severe form of acne that may evolve from acne vulgaris, especially in male adolescents, or occur as an adverse effect of oral isotretinoin. Arthritis is a serious clinical manifestation when the musculoskeletal system is compromised by AF and has been reported as a rare adverse effect of isotretinoin. Involvement of the sacroiliac joints occurs in 21% of acne fulminans cases. We present the case of a 18-year-old male patient in whom acne fulminans evolved from acne vulgaris grade IV and after inflammation resolution started treatment with oral isotretinoin. Within a 30-day period of retinoid treatment he presented with back pain followed by rapid, progressive inability to deambulate.

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Section: Discussionmentioning

confidence: 99%

“…When accompanied by arthritis, the sacroiliac articulations are involved in 21% of the cases reported on the literature. 5,6 There are reports of acne fulminans caused by isotretinoin, however in none of them it is related to the antigen HLA-B27. 7,8 …”

Section: Discussionmentioning

confidence: 99%

Sacroiliitis after use of oral isotretinoin - association with acne fulminans or adverse effect?

Geller¹,

Alagia²

2013

An. Bras. Dermatol.

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“…The systemic symptoms include high fever and polyarthralgia 1,2 . AF mainly affects young male adolescents with a history of acne vulgaris 3,4 . Laboratory findings typically show blood count abnormalities, with leukocytosis and neutrophilia, as well as elevated erythrocyte sedimentation rate and elevated C-reactive protein (CRP).…”

Section: Introductionmentioning

confidence: 99%

Acne fulminans in a Vietnamese boy successfully treated with prednisolone and ibuprofen: A case report

2018

Biomed. Res. Ther.

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Background: Acne fulminans (AF) is a rare disorder, the most severe form of the entire clinical spectrum of acne. It is characterized by the emergence of painful inflammatory nodules that turn into ulcers, concomitant with systemic manifestations. Here, we report for the first time a Vietnamese boy with Acne fulminans successfully treated with prednisolone and ibuprofen. Case presentation: The patient is a 14-year-old male teenager with moderate acne since the age of 13. After a day of swimming, his acne suddenly became inflamed and painful lesions were present on his face and back. He had high fever and polyarthritis, and tests showed leukocytosis, neutrophilia, and elevated C-reactive protein (CRP). Severe infection was diagnosed and treated by addition of antibacterial therapy for a long period, however, the condition did not improve. When called upon to evaluate the patient, we established the diagnosis of acne fulminans and initiated treatment with prednisone (1mg/kg/day) and ibuprofen (500 mg for two times daily). Following this treatment regimen, there was a rapid improvement. Conclusion: Herein, we have reported a Vietnamese boy with typical AF, but delayed diagnosis and treatment because of a rare condition. Our results support the role and benefit of prednisolone for AF treatment.

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“…gorączka, uczucie osłabienia, utrata masy ciała, bóle kostno-stawowe i bóle mięśni. Niekiedy obserwuje się powiększenie wątroby i śledziony, rumień guzowaty czy zapalenie wielostawowe [2,3]. W badaniach laboratoryjnych zwykle stwierdza się zwiększone stężenie parametrów ostrej fazy, m.in.…”

unclassified

“…białka C-reaktywnego (ang. C-reactive protein -CRP), leukocytozę, przyspieszone OB, niedokrwistość, niekiedy podwyższenie aktywności enzymów wątrobowych i białkomocz [3,4].…”

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Difficulties in the treatment of acne fulminans – case report

Kozłowska¹,

Baran²,

Flisiak³

2015

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Przegląd Dermatologiczny 2015/3 StreSzczenieWprowadzenie. Trądzik piorunujący (acne fulminans -AF) jest najcięż-szą postacią trądziku zwyczajnego. Występuje najczęściej u chłopców w wieku okołopokwitaniowym. Zmianom skórnym towarzyszą dolegliwości ogólnoustrojowe oraz odchylenia w badaniach laboratoryjnych. Cel pracy. Przedstawienie pacjenta z wywiadem trądziku zwyczajnego, u którego po 6 tygodniach leczenia izotretynoiną doszło do gwał-townego zaostrzenia zmian trądzikowych. Opis przypadku. Mężczyzna 38-letni z wywiadem trądziku zwyczajnego został przyjęty do Kliniki z powodu zmian o charakterze AF z towarzyszącą gorączką, utratą masy ciała i bólami mięśniowo-stawowymi, które rozwinęły się w trakcie terapii izotretynoiną. W badaniach laboratoryjnych obserwowano niedokrwistość oraz podwyższenie wykładników stanu zapalnego. Uzyskano częściową poprawę stanu miejscowego oraz ustąpienie dolegliwości ogólnych po włączeniu glikokortykosteroidoterapii. Próba dołączenia izotretynoiny spowodowała ponownie dolegliwości bólowe kręgosłupa. W leczeniu zastosowano limecyklinę, co skutkowało poprawą kliniczną. Wnioski. Trądzik piorunujący jest rzadkim powikłaniem terapii izotretynoiną. Ze względu na współistnienie objawów ogólnoustrojowych i ryzyko rozwoju szpecących blizn niezbędne jest postawienie szybkiej diagnozy klinicznej oraz wdrożenie odpowiedniego leczenia. AbStrActIntroduction. Acne fulminans is the most severe form of acne. It occurs predominantly in boys in the peripubertal period. Skin lesions are accompanied by general symptoms and laboratory abnormalities. Objective. Presentation of a patient with acne vulgaris in whom after 6 weeks of treatment with isotretinoin a rapid exacerbation of acne lesions occurred. Case report. A 38-year-old patient with a history of acne was admitted to the department due to severe symptoms of acne with associated fever, loss of weight and muscle and joint pain, which developed during isotretinoin therapy. Laboratory tests showed anemia and increased inflammatory markers. After administration of systemic glucocorticosteroids partial local improvement and regression of general symptoms were achieved. Addition of isotretinoin again caused pain of spine. After therapy with lymecycline a clinical improvement was achieved.trudności w leczeniu trądziku piorunującego -opis przypadku Difficulties in the treatment of acne fulminans -case report Dorota Kozłowska, Anna baran, iwona Flisiak

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Acne fulminans incapacitante

Cited by 14 publications

References 13 publications

Sacroiliitis after use of oral isotretinoin - association with acne fulminans or adverse effect?

Sacroiliitis after use of oral isotretinoin - association with acne fulminans or adverse effect?

Acne fulminans in a Vietnamese boy successfully treated with prednisolone and ibuprofen: A case report

Difficulties in the treatment of acne fulminans – case report

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