Ocorrência simultânea de necrobiose lipoídica ulcerada e granuloma anular em um paciente: relato de caso

Souza, Fernanda de Mello de Homem; Ribeiro, Camila Ferrari; Pereira, Marcela A. C.; Mesquita, Lismary; Fabricio, L

doi:10.1590/s0365-05962011000500023

Cited by 7 publications

(13 citation statements)

References 15 publications

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“…1 Early reports suggested that NL may be a variant of GA, and it was not until the mid 20th century that recognition of subtle microscopic differences permitted classification as different conditions. 2 Historically, they have been considered to be closely associated with diabetes mellitus; more recently the strength of the association has been questioned.…”

Section: Introductionmentioning

confidence: 99%

Necrobiosis lipoidica

George

Walton

2015

Br J Diabetes

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Necrobiosis lipoidica and granuloma annulare are granulomatous skin conditions that have been traditionally associated with diabetes mellitus, although recently the strength of association has been questioned. In the first section of this two-part article, we describe the suggested aetiology, clinical features, histology and treatment of necrobiosis lipoidica. It is found in 0.3% of patients with diabetes, but has also been reported with other systemic conditions. Clinically it appears as a waxy, atrophic, yellowish plaque with overlying telangiectasia and a brown border. Although usually asymptomatic, it may be extremely painful, especially if ulcerated. Squamous cell carcinoma has occasionally been reported with longstanding lesions. Treatment is often difficult: numerous topical and systemic agents have been employed, but evidence is limited to small case series and individual case reports. Br J Diabetes 2016;16:6-9

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Section: Introductionmentioning

confidence: 99%

Necrobiosis lipoidica

George

Walton

2015

Br J Diabetes

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“…13,14 Possible reasons for the apparent different rates of association with diabetes could be explained by differences in the pathogenesis of these conditions.…”

Section: Association With Diabetesmentioning

confidence: 99%

Necrobiosis lipoidica and granuloma annulare: Part 2- Granuloma annulare

George

Walton

2015

Br J Diabetes

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Granuloma annulare is a benign, self-limiting condition that occurs in 4% of patients with diabetes. It is usually asymptomatic; various clinical subtypes have been described, including localised, generalised, subcutaneous and perforating. The aetiology and pathogenesis is unknown, although several theories have been proposed. Numerous therapeutic strategies are documented in the literature, however, while treatment may be requested for cosmetically disfiguring or pruritic lesions, an explanation of the condition is often all that is necessary. Br J Diabetes 2016;16:58-61

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“…Necrobiosis lipoidica (NL) is a rare chronic granulomatous disease characterized by erythematous papules or plaques that grow centrifugally, becoming brownish-yellow with central atrophy [ 3 ]. The lesions are typically seen in the pretibial region, but can also appear on the face, penis, scalp, and trunk.…”

Section: Introductionmentioning

confidence: 99%

“…Both dermatoses remain unclear in their pathogenesis. Delayed-type hypersensitivity has been postulated to cause GA [ 5 – 8 ]; other authors mention vasculitis as a potential mechanism [ 3 , 9 , 10 ]. Microangiopathy has been suggested to play a role in the etiology and pathogenesis of NL [ 4 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature

Rupley

Riahi

Hooper

2015

Dermatol Pract Concept

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Granuloma annulare (GA) and necrobiosis lipoidica (NL) are granulomatous diseases of undetermined etiology. Rarely, both dermatoses have been reported to occur concomitantly in patients. GA and NL are characterized histologically by areas of necrobiosis of collagen. The two diseases share some common characteristics, which may suggest that these dermatoses could occur as a spectrum in some patients or possibly share a similar pathogenesis. We report on a 67-year-old Caucasian woman with a history of NL on the anterior shins that later developed lesions of GA on the breasts, trunk, and wrist. We also review the literature and discuss the characteristics of patients with concomitant GA and NL.

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Ocorrência simultânea de necrobiose lipoídica ulcerada e granuloma anular em um paciente: relato de caso

Cited by 7 publications

References 15 publications

Necrobiosis lipoidica

Necrobiosis lipoidica

Necrobiosis lipoidica and granuloma annulare: Part 2- Granuloma annulare

Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature

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