Background: Efficacious topical medications for rosacea are needed. FMX103 1.5% is a novel topical minocycline foam that may have therapeutic benefits in treating rosacea while minimizing systemic adverse effects due to its topical route of delivery. Objective: To determine the efficacy, safety, and tolerability of 12 weeks of treatment with FMX103 1.5% topical minocycline foam for papulopustular rosacea. Methods: Two 12-week, phase 3, randomized, multicenter, double-blind, vehicle-controlled, 2-arm studies were performed in patients with moderate to severe papulopustular rosacea. Results: Participants who received FMX103 1.5%, versus control individuals treated with vehicle, exhibited a significantly greater reduction in the number of inflammatory lesions (FX2016-11:-17.57 vs-15.65; P = .0031; FX2016-12:-18.54 vs-14.88; P \ .0001) and higher rates of Investigator Global Assessment treatment success (FX2016-11: 52.1% vs 43.0%; P = .0273; FX2016-12: 49.1% vs 39.0%; P = .0077). No serious treatment-related treatment-emergent adverse events occurred. Limitations: The generalizability of these data from a controlled clinical trial should be examined in a real-world setting. Conclusions: FMX103 1.5% was efficacious for moderate to severe papulopustular rosacea and maintained a favorable safety profile.
Background: FMX101 4% topical minocycline foam has been shown to be an effective and safe treatment for acne vulgaris (AV).Objective: To further evaluate the efficacy and safety of FMX101 4% in treating moderate to severe acne vulgaris.Methods: A 12-week, multicenter, randomized (1:1), double-blind, vehicle-controlled study was conducted. Coprimary end points were the absolute change in inflammatory lesion count from baseline and the rate of treatment success (Investigator's Global Assessment score of 0 or 1 with a $2-grade improvement).Results: There were 1488 participants in the intent-to-treat population. The FMX101 4% group had significantly greater reductions in the number of inflammatory lesions from baseline (P \ .0001) and a greater rate of treatment success based on Investigator's Global Assessment (P \ .0001) versus the foam vehicle group at week 12. FMX101 4% was generally safe and well tolerated.
Limitations:The efficacy and safety of FMX101 4% were not characterized in participants with mild AV.Conclusion: FMX101 4% topical minocycline foam was effective and safe for the treatment of moderate to severe AV.
This modality may provide patients with SCC in cosmetically important locations or in areas that require complex surgery the advantage of a nonsurgical cure.
Summary
Introduction
Skin cleansing is important for removal of dirt, debris, and sebum and plays an important role in reduction of pollution‐induced skin aging. Cleansing is an established part of treatment recommendations and procedures in dermatology. Different methods for facial skin cleansing are established but recommendations on use of special devices are not fully integrated into clinical practice.
Aim
We review the current literature on sonic cleansing to demonstrate that a gentle and effective cleansing routine using a sonic brush followed by appropriate additional methods for rehydration and skin protection may improve both inflammatory conditions including acne vulgaris and skin damage associated with overexposure to exogenous light and pollution.
Methods
A working group of experienced clinicians managing facial inflammatory skin conditions convened for a meeting. The panel reviewed the literature surrounding sonic brush cleansing and discussed clinical questions aiming to optimize facial cleansing outcomes.
Results
The panel agreed there are increasing concerns over the rise of atmospheric pollution globally and its impact on health and skin aging and that cleansing in combination with nonspecific skin care is able to support physiological microenvironmental skin conditions including pH levels on the skin surface, barrier function, and hydration.
Conclusion
Cleansing poses a challenge in balancing debris removal while avoiding excess sebum removal, thereby maintaining an intact stratum corneum barrier. The sonic brush may offer a safe and effective treatment for various conditions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.