2011
DOI: 10.1590/s0365-05962011000200021
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Lupus eritematoso neonatal: reporte de cuatro casos

Abstract: Neonatal lupus erythematosus is a very rare disease, clinically characterized by skin lesions that resemble those of subacute or discoid lupus erythematosus and/or congenital heart block. Generally, when patients have skin manifestations, they have no cardiac defects and vice-versa; however, in 10% of cases these manifestations may coexist. Other findings may include hematologic, hepatic and neurological abnormalities. This condition is caused by the transplacental passage of maternal autoantibodies against Ro… Show more

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Cited by 15 publications
(11 citation statements)
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“…9 While such conditions are relatively uncommon and the offending IgG are cleared from the infant’s circulation within the first 6 months of life, situations where IgG alters important developmental processes can lead to permanent defects. For example, in some cases of neonatal lupus erythematosis, 10 characteristic maternal antibodies, which bind to the ribosomal Ro ribonucleoprotein, prevent proper heart formation in the developing fetus, thereby requiring corrective surgery in the newborn.…”
Section: Gestational Roles Of Maternal Iggmentioning
confidence: 99%
“…9 While such conditions are relatively uncommon and the offending IgG are cleared from the infant’s circulation within the first 6 months of life, situations where IgG alters important developmental processes can lead to permanent defects. For example, in some cases of neonatal lupus erythematosis, 10 characteristic maternal antibodies, which bind to the ribosomal Ro ribonucleoprotein, prevent proper heart formation in the developing fetus, thereby requiring corrective surgery in the newborn.…”
Section: Gestational Roles Of Maternal Iggmentioning
confidence: 99%
“…In addition to its presence in the skin and heart, the Ro antigen is also found in the liver, bowel, lungs, brain, and blood cells—the tissues that are most often affected by NLE [3]. Ultraviolet radiation and estrogens increase Ro antigen expression on the surface of the keratinocyte [3].…”
Section: Pathophysiologymentioning
confidence: 99%
“…Ultraviolet radiation and estrogens increase Ro antigen expression on the surface of the keratinocyte [3]. Although ultraviolet radiation can induce or exacerbate the skin lesions, it is not required for their development [10].…”
Section: Pathophysiologymentioning
confidence: 99%
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“…[345] Both mother and the child are at an increased risk of developing some rheumatologic or autoimmune disease in future. [3567]…”
Section: Discussionmentioning
confidence: 99%